Patents by Inventor Bruce W. Horrom

Patent number: 5504207
Abstract: A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate.
Type: Grant
Filed: October 18, 1994
Date of Patent: April 2, 1996
Assignee: Abbott Laboratories
Inventors: Anthony Mannino, Rodger F. Henry, Wayne R. Heitmann, Bruce W. Horrom
Patent number: 5275950
Abstract: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
Type: Grant
Filed: February 10, 1993
Date of Patent: January 4, 1994
Assignee: Abbott Laboratories
Inventors: Daniel A. Dickman, Bruce W. Horrom, Chi-Nung W. Hsiao, M. Robert Leanna, Hormoz Mazdiyasni, Howard E. Morton, Thomas M. Zydowsky, William R. Baker, Stephen L. Condon
Patent number: 5212176
Abstract: R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.
Type: Grant
Filed: June 29, 1990
Date of Patent: May 18, 1993
Assignee: Abbott Laboratories
Inventors: John J. Kyncl, Bruce W. Horrom
Patent number: 5169961
Abstract: A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.
Type: Grant
Filed: November 22, 1991
Date of Patent: December 8, 1992
Assignee: Abbott Laboratories
Inventors: Daniel A. Dickman, Bruce W. Horrom, Brian A. Roden, Sanjay R. Chemburkar
Patent number: 5120752
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
Type: Grant
Filed: December 6, 1990
Date of Patent: June 9, 1992
Assignee: Abbott Laboratories
Inventors: Dee W. Brooks, Karen E. Rodriques, Bruce W. Horrom, Hormoz Mazdiyasni
Patent number: 4375478
Abstract: Described are compounds of the formula ##STR1## wherein Y and Z independently of one another denote hydrogen, halo or trihalomethyl, with the proviso that Y and Z cannot both be hydrogen, R is hydrogen or loweralkyl, n is 5 to 19, and pharmaceutically acceptable salts thereof.The compounds are active hypocholesterolemic agents.
Type: Grant
Filed: March 2, 1982
Date of Patent: March 1, 1983
Assignee: Abbott Laboratories
Inventors: Bruce W. Horrom, Herman H. Stein
Patent number: 4191760
Abstract: This invention provides dibenzodiazepines represented by the formula ##STR1## The compounds of this invention are useful as antischizophrenics.
Type: Grant
Filed: February 13, 1978
Date of Patent: March 4, 1980
Assignee: Abbott Laboratories
Inventors: Bruce W. Horrom, William D. Barta