Patents by Inventor Bruce W. Horrom

Bruce W. Horrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and intermediate for the preparation of terazosin hydrochloride dihydrate
    Patent number: 5504207
    Abstract: A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: April 2, 1996
    Assignee: Abbott Laboratories
    Inventors: Anthony Mannino, Rodger F. Henry, Wayne R. Heitmann, Bruce W. Horrom
  • Process for the preparation of a renin inhibiting compound
    Patent number: 5275950
    Abstract: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: January 4, 1994
    Assignee: Abbott Laboratories
    Inventors: Daniel A. Dickman, Bruce W. Horrom, Chi-Nung W. Hsiao, M. Robert Leanna, Hormoz Mazdiyasni, Howard E. Morton, Thomas M. Zydowsky, William R. Baker, Stephen L. Condon
  • R(+)-terazosin
    Patent number: 5212176
    Abstract: R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: May 18, 1993
    Assignee: Abbott Laboratories
    Inventors: John J. Kyncl, Bruce W. Horrom
  • Process for the production of 2-acetylbenzo [.beta.]thiophenes
    Patent number: 5169961
    Abstract: A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.
    Type: Grant
    Filed: November 22, 1991
    Date of Patent: December 8, 1992
    Assignee: Abbott Laboratories
    Inventors: Daniel A. Dickman, Bruce W. Horrom, Brian A. Roden, Sanjay R. Chemburkar
  • Cyclopropyl derivative lipoxygenase inhibitors
    Patent number: 5120752
    Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: June 9, 1992
    Assignee: Abbott Laboratories
    Inventors: Dee W. Brooks, Karen E. Rodriques, Bruce W. Horrom, Hormoz Mazdiyasni
  • Aminobenzoic acid derivatives
    Patent number: 4375478
    Abstract: Described are compounds of the formula ##STR1## wherein Y and Z independently of one another denote hydrogen, halo or trihalomethyl, with the proviso that Y and Z cannot both be hydrogen, R is hydrogen or loweralkyl, n is 5 to 19, and pharmaceutically acceptable salts thereof.The compounds are active hypocholesterolemic agents.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: March 1, 1983
    Assignee: Abbott Laboratories
    Inventors: Bruce W. Horrom, Herman H. Stein
  • Dibenzodiazepines
    Patent number: 4191760
    Abstract: This invention provides dibenzodiazepines represented by the formula ##STR1## The compounds of this invention are useful as antischizophrenics.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: March 4, 1980
    Assignee: Abbott Laboratories
    Inventors: Bruce W. Horrom, William D. Barta