Patents by Inventor Bruce W. Horrom

Bruce W. Horrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Patent number: 5504207
Abstract: A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate.
Type: Grant
Filed: October 18, 1994
Date of Patent: April 2, 1996
Assignee: Abbott Laboratories
Inventors: Anthony Mannino, Rodger F. Henry, Wayne R. Heitmann, Bruce W. Horrom
Patent number: 5275950
Abstract: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
Type: Grant
Filed: February 10, 1993
Date of Patent: January 4, 1994
Assignee: Abbott Laboratories
Inventors: Daniel A. Dickman, Bruce W. Horrom, Chi-Nung W. Hsiao, M. Robert Leanna, Hormoz Mazdiyasni, Howard E. Morton, Thomas M. Zydowsky, William R. Baker, Stephen L. Condon
Patent number: 5212176
Abstract: R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.
Type: Grant
Filed: June 29, 1990
Date of Patent: May 18, 1993
Assignee: Abbott Laboratories
Inventors: John J. Kyncl, Bruce W. Horrom
Patent number: 5169961
Abstract: A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.
Type: Grant
Filed: November 22, 1991
Date of Patent: December 8, 1992
Assignee: Abbott Laboratories
Inventors: Daniel A. Dickman, Bruce W. Horrom, Brian A. Roden, Sanjay R. Chemburkar
Patent number: 5120752
Abstract: Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.
Type: Grant
Filed: December 6, 1990
Date of Patent: June 9, 1992
Assignee: Abbott Laboratories
Inventors: Dee W. Brooks, Karen E. Rodriques, Bruce W. Horrom, Hormoz Mazdiyasni
Patent number: 4375478
Abstract: Described are compounds of the formula ##STR1## wherein Y and Z independently of one another denote hydrogen, halo or trihalomethyl, with the proviso that Y and Z cannot both be hydrogen, R is hydrogen or loweralkyl, n is 5 to 19, and pharmaceutically acceptable salts thereof.The compounds are active hypocholesterolemic agents.
Type: Grant
Filed: March 2, 1982
Date of Patent: March 1, 1983
Assignee: Abbott Laboratories
Inventors: Bruce W. Horrom, Herman H. Stein
Patent number: 4191760
Abstract: This invention provides dibenzodiazepines represented by the formula ##STR1## The compounds of this invention are useful as antischizophrenics.
Type: Grant
Filed: February 13, 1978
Date of Patent: March 4, 1980
Assignee: Abbott Laboratories
Inventors: Bruce W. Horrom, William D. Barta