Patents by Inventor Bruno Le Pioufle

Bruno Le Pioufle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11172885
    Abstract: A medical device including an electric measurement circuit, in which are connected at least two sensors the impedance of which varies as a function of a sensed physical parameter, a source of electrical power for powering the electric measurement circuit, an antenna for emitting an electromagnetic field as a function of the impedance of the electric measurement circuit, each of the sensors being associated with a switch for short circuiting the sensor in the measurement circuit, the medical device further including a system for controlling the switches in order successively to command the opening or closing of the switches in determined configurations. The medical device may notably be able to be applied to the human body or implanted in the human body.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: November 16, 2021
    Assignees: Centre National de la Recherche Scientifique, Ecole Polytechnique, Ecole Normale Superieure de Cachan
    Inventors: Abdul Barakat, Franz Bozsak, Yvan Eric Bonnassieux, Bruno Le Pioufle, Olivier Francais, Bruno Carreel
  • Patent number: 10912482
    Abstract: The invention relates to a method for discriminating cells of a cellular structure, notably of a cellular tissue, comprising the steps consisting in determining (12) a frequency spectrum of the impedance of the cellular structure; defining (22) at least one model of the impedance of the cellular structure including a constant phase element (30); determining (44) the impedance of the constant phase element (30) which optimizes the correlation of each model of the impedance of the cellular structure with the spectrum; and deducing (66), from the impedance of the constant phase element (30) or from the impedances of the constant phase elements (30), an item of information on the cells of the cellular structure. The invention also relates to a system for implementing the method for discriminating cells of a cellular structure.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: February 9, 2021
    Assignee: Sensome SAS
    Inventors: Franz Bozsak, Abdul Barakat, Pierluca Messina, Olivier Francais, Bruno Carreel, Bruno Le Pioufle, Myline Cottance
  • Publication number: 20180303372
    Abstract: The invention relates to a method for discriminating cells of a cellular structure, notably of a cellular tissue, comprising the steps consisting in determining (12) a frequency spectrum of the impedance of the cellular structure; defining (22) at least one model of the impedance of the cellular structure including a constant phase element (30); determining (44) the impedance of the constant phase element (30) which optimizes the correlation of each model of the impedance of the cellular structure with the spectrum; and deducing (66), from the impedance of the constant phase element (30) or from the impedances of the constant phase elements (30), an item of information on the cells of the cellular structure. The invention also relates to a system for implementing the method for discriminating cells of a cellular structure.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Inventors: Franz Bozsak, Abdul Barakat, Pierluca Messina, Olivier Francais, Bruno Carreel, Bruno Le Pioufle, Myline Cottance
  • Publication number: 20180235545
    Abstract: A medical device including an electric measurement circuit, in which are connected at least two sensors the impedance of which varies as a function of a sensed physical parameter, a source of electrical power for powering the electric measurement circuit, an antenna for emitting an electromagnetic field as a function of the impedance of the electric measurement circuit, each of the sensors being associated with a switch for short circuiting the sensor in the measurement circuit, the medical device further including a system for controlling the switches in order successively to command the opening or closing of the switches in determined configurations. The medical device may notably be able to be applied to the human body or implanted in the human body.
    Type: Application
    Filed: October 2, 2015
    Publication date: August 23, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE POLYTECHNIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN
    Inventors: Abdul BARAKAT, Franz BOZSAK, Yvan Eric BONNASSIEUX, Bruno LE PIOUFLE, Olivier FRANCAIS, Bruno CARREEL
  • Patent number: 8705223
    Abstract: The present disclosure relates to a method for producing an insulated electrode comprising a conductive material coated with an electrically insulating material. The method includes at least the following steps of: forming a mold in an electrically insulating material, the mold including at least one channel, the mold being adapted to confine a conductive material, introducing the conductive material in a liquid state into the channel of the mold, the conductive material having a melting point that is lower than the melting point of the electrically insulating material.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: April 22, 2014
    Assignees: Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure de Cachan, Institut Gustave-Roussy
    Inventors: Julien Villemejane, Bruno Le Pioufle, Luis Maria Mir, Olivier Francais, Jean-Pierre Lefevre
  • Patent number: 8038966
    Abstract: The invention relates to a durable hydrophilic non-porous surface-modified polymer composition, to aqueous fluid channels based on said composition, to a microfluidic system comprising said channels, to a method for the production thereof and to a microfluidic chip or cells incorporating said composition.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: October 18, 2011
    Assignees: Centre National de la Recherche Scientifique, Ecole Normale Superieure de Cachan, Association pour les Transferts de Technologie du Mans
    Inventors: Laurent Griscom, Bruno Le Pioufle, Gilbert Legeay
  • Publication number: 20110141649
    Abstract: The present disclosure relates to a method for producing an insulated electrode comprising a conductive material coated with an electrically insulating material.
    Type: Application
    Filed: August 20, 2009
    Publication date: June 16, 2011
    Inventors: Julien Villemejane, Bruno Le Pioufle, Luis Maria Mir, Olivier Francais, Jean-Pierre Lefevre
  • Publication number: 20110118811
    Abstract: The present disclosure relates to the delivery of electric pulses any organic or inorganic conductive material and/or any biological material and/or to cells in vivo, ex vivo or in vitro, for example for the electroporation of the cells, for the electrically mediated transfer gene transfer of nucleic acids into tissue cell using a pulsed electric field and/or for the electromanipulation, in general, of the cell membrane or of the cell inside. The electric pulse applicator for the treatment of a conductive material such as biological material allowing an electric field to be applied to said conductive material in such a way as to modify it properties, includes at least one electrode including a conductive main body and an electrically insulating coating intended to be introduced into and/or at the vicinity of the conductive material to be treated, and a pulse generator sending pulses to the electrodes having a slope (dE/dt) greater than 1015 V/m/s.
    Type: Application
    Filed: July 21, 2009
    Publication date: May 19, 2011
    Inventors: Julien VillemeJane, Bruno Le Pioufle, Luis Maria Mir
  • Publication number: 20080260588
    Abstract: The invention relates to a durable hydrophilic non-porous surface-modified polymer composition, to aqueous fluid channels based on said composition, to a microfluidic system comprising said channels, to a method for the production thereof and to a microfluidic chip or cells incorporating said composition.
    Type: Application
    Filed: May 10, 2005
    Publication date: October 23, 2008
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN, ASSOCIATION POUR LES TRANSFERTS DE TECHNOLOGIE DU
    Inventors: Laurent Griscom, Bruno Le Pioufle, Gilbert Legeay
  • Publication number: 20050040044
    Abstract: A system for using dielectrophoresis to manipulate dielectric particles, in particular biological cells in suspension in a medium and subjected to the action of an alternating electric field of distribution that is made to be non-uniform by means of a regular array of electrodes suitable for defining local zones where the electric field is at a minimum in rows to concentrate particles in said local zones by the action of negative dielectrophoresis forces, wherein the array of electrodes is formed on the surface of a multilayer substrate, and wherein the same-polarity electrodes of the array are connected to respective common power supply pads via two arrays of conductor tracks which are formed at an intermediate level situated beneath the array of electrodes.
    Type: Application
    Filed: October 21, 2002
    Publication date: February 24, 2005
    Inventors: Marie Frenea, Bruno Le Pioufle, Herve Lhermite
  • Publication number: 20040238484
    Abstract: A method of manufacturing a microfluidic structure, in particular a biochip, said method consisting at least:
    Type: Application
    Filed: July 12, 2004
    Publication date: December 2, 2004
    Inventors: Bruno Le Pioufle, Horoyuki Fujita, Eiichi Tamiya, Laurent Griscom, Patrick Degenaar