Patents by Inventor Bruno Miguel da Cruz Godinho

Bruno Miguel da Cruz Godinho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDE-BASED MODULATION OF C9orf72
    Publication number: 20240132892
    Abstract: This disclosure relates to novel C9ORF72 targeting sequences. Novel oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: April 25, 2024
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, James W. Gilbert
  • Branched oligonucleotides
    Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • UNIVERSAL DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORS
    Publication number: 20230061751
    Abstract: Therapeutic oligonucleotides comprising universal pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more universal PK-modifying anchors are provided.
    Type: Application
    Filed: January 15, 2021
    Publication date: March 2, 2023
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION
    Publication number: 20230021431
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Application
    Filed: May 28, 2021
    Publication date: January 26, 2023
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O'Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi
  • DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORS
    Publication number: 20220372476
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Application
    Filed: April 20, 2022
    Publication date: November 24, 2022
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Dynamic pharmacokinetic-modifying anchors
    Patent number: 11492619
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: November 8, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Bruno Miguel Da Cruz Godinho, Matthew Hassler
  • DUAL-ACTING siRNA BASED MODULATION OF C9orf72
    Publication number: 20210340535
    Abstract: This disclosure relates to novel C9ORF72 targeting sequences. Novel sense and antisense dual-targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: March 26, 2021
    Publication date: November 4, 2021
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, James W. Gilbert
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20210085793
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 25, 2021
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • OLIGONUCLEOTIDE-BASED MODULATION OF C9orf72
    Publication number: 20200385737
    Abstract: This disclosure relates to novel C9ORF72 targeting sequences. Novel oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: March 27, 2020
    Publication date: December 10, 2020
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, James W. Gilbert
  • Branched oligonucleotides
    Patent number: 10799591
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 13, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORS
    Publication number: 20200270605
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Application
    Filed: January 17, 2020
    Publication date: August 27, 2020
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Branched oligonucleotides
    Patent number: 10478503
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: November 19, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20190247507
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho