Abstract: Folded box (2) with an anti-tamper seal, especially for the packaging of drugs. The box has a body (19) that has at least one closure component that closes off the body. A seal for protecting the box from unauthorized opening is positioned between the closure component (12, 14, 20) and the body of the box. To provide an anti-tamper seal that is simple, inexpensive to manufacture, and reliable, an aperture (22, 24, 30, 32) is positioned on the body or closure component at a point that, once the box has been closed, one area (20) of the closure component or of the body (18) will be behind and a layer (50) of hardened melting adhesive constitutes a seal bonding the closure component (12, 14, 18) and the body (19) of the box together. The invention also concerns a method of manufacturing such a box.