Abstract: Disclosed herein are recombinant adenoviruses with one or more nucleotide sequences inserted between two viral transcription units, formulations comprising the recombinant adenoviruses, and methods of treatment using the recombinant adenoviruses. In some embodiments, the one or more nucleotide sequences are inserted in an IX-E2 insertion site and/or an L5-E4 insertion site.

Abstract: Disclosed herein are recombinant adenoviruses with one or more nucleotide sequences inserted between two viral transcription units, formulations comprising the recombinant adenoviruses, and methods of treatment using the recombinant adenoviruses. In some embodiments, the one or more nucleotide sequences are inserted in an IX-E2 insertion site and/or an L5-E4 insertion site.

Abstract: Disclosed herein are recombinant adenoviruses with one or more nucleotide sequences inserted between two viral transcription units, formulations comprising the recombinant adenoviruses, and methods of treatment using the recombinant adenoviruses. In some embodiments, the one or more nucleotide sequences are inserted in an IX-E2 insertion site and/or an L5-E4 insertion site.

Abstract: A method is provided for treating cancer in a mammalian subject by inhibiting angiogenesis through the administration to the subject of a therapeutically effective amount of a nitrate-containing compound and a therapeutically effective amount of an inorganic selenium-containing compound. Kits and systems are also disclosed for practicing the subject methods.

Abstract: Prostate probe systems are disclosed for assessing one or both of BPH or prostate cancer. The prostate probe systems comprise either a force or pressure sensor mounted on or in a rectally insertable probe or a temperature sensor mounted on or in a rectally insertable probe, or both. Also disclosed are probe systems for evaluating a condition of a prostate gland. Finally, force or hardness mapping devices are disclosed for palpation-examination of patient anatomical tissues for abnormalities or assessing states of firmness.

Abstract: A gel-like material is provided, the gel-like material having an on-demand state-change capability, whether the on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Alternatively, the gel-like material may have a spatially and/or temporally selective state-change, whether on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Or, the gel-like material may selectively change state due to gel contacting diseased tissue having a natural thermal or compositional contrast or artificially induced thermal or compositional contrast capable of causing state-change via a state-change parameter, independent of an on-demand nature or a spatial/temporal selective nature.

Abstract: The invention features a thermal and/or light-protective container assembly that includes a flexible outer and inner layer, as well as a thermoregulatory material disposed between said outer and inner layers. In general, the invention is directed to a thermal and/or light-protective container assembly, such as a form-fitting sleeve, that includes a flexible layered wall having an opened end and a contiguous closed end, wherein the wall defines a centrally located cavity. The wall further includes an outer layer and an inner layer, wherein uniformly disposed between the outer and inner layers is a thermoregulatory material that is configured for insulating an object, and/or for transferring heat or cold to the object, and/or maintaining the temperature of the object disposed within the defined cavity of the sleeve.

Abstract: The invention features a dental hygiene article that includes a retractable portion and a chamber portion for use in conjunction with the same, as well as methods of use to promote good oral hygiene practices. In general, the invention is directed to a dental hygiene article, such as a toothbrush, wherein the device includes a retractable proximal portion that contains one or both of a head assembly and a stem portion, a chamber portion that is configured for receiving the retractable proximal portion, and a handle portion, which may be detachable. Accordingly, when the retractable portion is in a retracted configuration the head assembly is encased within the chamber, which may then be filled with an additive, such as a fluid medicament, disinfectant, cleaning solution, or the like, so as to treat the head assembly prior to use.

Abstract: The invention features interdental hygiene articles, as well as dispensers for use in conjunction with such and methods of use to promote good oral hygiene practices. In particular the invention is directed to interdental hygiene articles such as flosses, tapes, ribbons, and/or the like, wherein the interdental hygiene articles includes one or more graphics on one ore more sides of the article. The graphic demarcates a recommended length of the article to be used in a single use procedure, and can be provided so as to promote use of the article over different regions of the length used.