Patents by Inventor Bryan Steadman

Bryan Steadman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Virus like particle purification
    Patent number: 10792353
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 6, 2020
    Assignee: Takeda Vaccines, Inc.
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
  • VIRUS LIKE PARTICLE PURIFICATION
    Publication number: 20190282686
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Application
    Filed: December 7, 2018
    Publication date: September 19, 2019
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
  • Virus like particle purification
    Patent number: 10172930
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 8, 2019
    Assignee: TAKEDA VACCINES, INC.
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
  • Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
    Patent number: 9518096
    Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: December 13, 2016
    Assignee: TAKEDA VACCINES, INC.
    Inventors: Charles Richardson, Robert F. Bargatze, Joel Haynes, Bryan Steadman
  • VIRUS LIKE PARTICLE PURIFICATION
    Publication number: 20160317645
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 3, 2016
    Inventors: Thomas S. VEDVICK, Bryan STEADMAN, Charles RICHARDSON, Thomas R. FOUBERT, Charles R. PETRIE
  • Virus like particle purification
    Patent number: 9359410
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: June 7, 2016
    Assignee: TAKEDA VACCINES INC.
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
  • TARGETED HETEROLOGOUS ANTIGEN PRESENTATION ON CALICIVIRUS VIRUS-LIKE PARTICLES
    Publication number: 20150252082
    Abstract: The present invention provides particle-forming chimeric proteins comprising a Calicivirus capsid protein and one or more heterologous antigen sequences. In particular, the present invention discloses engineered Calicivirus capsid protein sequences containing heterologous epitopes fused at internal locations such that the modified capsid proteins retain the ability to form virus-like particles when expressed in host cells. Virus-like particles comprising the chimeric proteins and vaccine formulations are also described.
    Type: Application
    Filed: February 9, 2015
    Publication date: September 10, 2015
    Inventors: Bryan STEADMAN, Ross Taylor
  • Targeted heterologous antigen presentation on calicivirus virus-like particles
    Patent number: 8980275
    Abstract: The present invention provides particle-forming chimeric proteins comprising a Calicivirus capsid protein and one or more heterologous antigen sequences. In particular, the present invention discloses engineered Calicivirus capsid protein sequences containing heterologous epitopes fused at internal locations such that the modified capsid proteins retain the ability to form virus-like particles when expressed in host cells. Virus-like particles comprising the chimeric proteins and vaccine formulations are also described.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: March 17, 2015
    Assignee: Takeda Vaccines, Inc.
    Inventors: Bryan Steadman, Ross Taylor
  • VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY
    Publication number: 20150023995
    Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
    Type: Application
    Filed: July 25, 2014
    Publication date: January 22, 2015
    Applicant: TAKEDA VACCINES, INC.
    Inventors: Charles RICHARDSON, Robert F. BARGATZE, Joel HAYNES, Bryan STEADMAN
  • Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
    Patent number: 8841120
    Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: September 23, 2014
    Assignee: Takeda Vaccines, Inc.
    Inventors: Charles Richardson, Robert F. Bargatze, Joel Haynes, Bryan Steadman
  • METHODS FOR STABILIZING INFLUENZA ANTIGEN ENVELOPED VIRUS-BASED VIRUS-LIKE PARTICLE SOLUTIONS
    Publication number: 20140186396
    Abstract: Methods of stabilizing solutions with enveloped virus-based virus-like particles containing an influenza antigen and such stabilized solutions are described.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 3, 2014
    Applicant: TAKEDA VACCINES, INC.
    Inventors: Joel R. HAYNES, Bryan STEADMAN
  • VIRUS LIKE PARTICLE PURIFICATION
    Publication number: 20130344107
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Application
    Filed: June 10, 2013
    Publication date: December 26, 2013
    Inventors: THOMAS S. VEDVICK, BRYAN STEADMAN, CHARLES RICHARDSON, THOMAS R. FOUBERT, CHARLES R. PETRIE
  • Virus like particle purification
    Patent number: 8481693
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: July 9, 2013
    Assignee: Takeda Vaccines (Montana), Inc.
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
  • TARGETED HETEROLOGOUS ANTIGEN PRESENTATION ON CALICIVIRUS VIRUS-LIKE PARTICLES
    Publication number: 20130052216
    Abstract: The present invention provides particle-forming chimeric proteins comprising a Calicivirus capsid protein and one or more heterologous antigen sequences. In particular, the present invention discloses engineered Calicivirus capsid protein sequences containing heterologous epitopes fused at internal locations such that the modified capsid proteins retain the ability to form virus-like particles when expressed in host cells. Virus-like particles comprising the chimeric proteins and vaccine formulations are also described.
    Type: Application
    Filed: January 21, 2011
    Publication date: February 28, 2013
    Applicant: LIGOCYTE PHARMACEUTICALS, INC.
    Inventors: Bryan Steadman, Ross Taylor
  • METHODS FOR STABILIZING INFLUENZA ANTIGEN ENVELOPED VIRUS-BASED VIRUS-LIKE PARTICLE SOLUTIONS
    Publication number: 20130028933
    Abstract: Methods of stabilizing solutions with enveloped vims-based virus-like particles containing an influenza antigen and such stabilized solutions are described.
    Type: Application
    Filed: December 28, 2010
    Publication date: January 31, 2013
    Applicant: LigoCyte Pharmaceuticals, Inc.
    Inventors: Joel R. Haynes, Bryan Steadman
  • VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY
    Publication number: 20110195113
    Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 11, 2011
    Applicant: LigoCyte Pharmaceuticals, Inc.
    Inventors: Charles RICHARDSON, Robert F. Bargatze, Joel Haynes, Bryan Steadman
  • VIRUS LIKE PARTICLE PURIFICATION
    Publication number: 20100150961
    Abstract: Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
    Type: Application
    Filed: March 14, 2008
    Publication date: June 17, 2010
    Inventors: Thomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie