Patents by Inventor Bryson Bennett
Bryson Bennett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180296568Abstract: An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.Type: ApplicationFiled: February 26, 2018Publication date: October 18, 2018Inventors: Bryson Bennett, Ron L. Hale, Amy Lu, Daniel J. Myers, Joshua D. Rabinowitz, Krishnamohan Sharma, Martin J. Wensley
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Patent number: 9757407Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.Type: GrantFiled: December 21, 2015Date of Patent: September 12, 2017Assignee: The Trustees of Princeton UniversityInventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
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Publication number: 20160346309Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.Type: ApplicationFiled: December 21, 2015Publication date: December 1, 2016Inventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
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Patent number: 9029413Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, and in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. Antiviral activity of enzyme inhibitors is demonstrated.Type: GrantFiled: April 3, 2012Date of Patent: May 12, 2015Assignee: The Trustees of Princeton UniversityInventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
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Publication number: 20140072605Abstract: An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.Type: ApplicationFiled: November 13, 2013Publication date: March 13, 2014Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Bryson Bennett, Ron L. Hale, Amy Lu, Daniel J. Myers, Joshua D. Rabinowitz, Krishnamohan Sharma, Martin J. Wensley
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Publication number: 20130065850Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.Type: ApplicationFiled: April 3, 2012Publication date: March 14, 2013Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Josh MUNGER, Bryson BENNETT, Thomas SHENK, Joshua RABINOWITZ
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Patent number: 8158677Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.Type: GrantFiled: June 2, 2008Date of Patent: April 17, 2012Assignee: The Trustees of Princeton UniversityInventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
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Publication number: 20110240014Abstract: An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.Type: ApplicationFiled: April 1, 2011Publication date: October 6, 2011Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Bryson Bennett, Ron L. Hale, Amy Lu, Daniel J. Myers, Krishnamohan Sharma, Joshua D. Rabinowitz
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Publication number: 20090239830Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.Type: ApplicationFiled: June 2, 2008Publication date: September 24, 2009Inventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
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Patent number: 6884346Abstract: A separation column and a method of making the separation column are provided. The separation column includes a separation channel and a separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a support and a stationary phase. The support includes a metal organic polymer, such as a photopolymer, and the stationary phase includes a bonded phase. The separation medium can be used to separate a sample of analytes.Type: GrantFiled: October 15, 2001Date of Patent: April 26, 2005Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson Bennett
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Patent number: 6866785Abstract: A separation column and a method of making the separation column are provided. The separation column includes a separation channel and fritless separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a metal organic polymer, such as a photopolymer. The separation medium can be used to separate a sample of analytes.Type: GrantFiled: August 13, 2001Date of Patent: March 15, 2005Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson Bennett
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Publication number: 20050034723Abstract: An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.Type: ApplicationFiled: August 4, 2004Publication date: February 17, 2005Inventors: Bryson Bennett, Ron Hale, Amy Lu, Daniel Myers, Krishnamohan Sharma, Joshua Rabinowitz
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Publication number: 20030062308Abstract: A separation column and a method of making the separation column are provided. The separation column includes a separation channel and fritless separation medium in the channel. The separation medium includes a porous matrix, and the porous matrix includes a metal organic polymer, such as a photopolymer. The separation medium can be used to separate a sample of analytes.Type: ApplicationFiled: August 13, 2001Publication date: April 3, 2003Inventors: Richard N. Zare, Maria T. Dulay, Joselito P. Quirino, Bryson Bennett
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Patent number: 6179286Abstract: A sheet receiving and stacking apparatus has an infeed tray to which sheets are sequentially fed with their printed side facing upwardly starting in order, sheet one to the last sheet of a set or job, and continuing through the last sheet of the set or job, the trailing end of successive sheets being elevated and progressively moved upwardly to form a stack of sheets commencing with the first fed sheet with the last fed sheet of a set or job at the bottom and stacked on an upper run of a sheet elevating device which provides a stacker for stacking sets or jobs in sequential order with the first fed sheet of each set or job on top.Type: GrantFiled: December 21, 1999Date of Patent: January 30, 2001Assignee: Gradco (Japan) Ltd.Inventor: Bryson Bennett
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Patent number: 5348288Abstract: A moving bin sorter has trays which are sequentially shifted upwardly and downwardly relative to a sheet inlet location by a rotary cam driven by an electric motor which drives the cams in opposite directions. The minimum force applied by the motor and lowest motor speed depends upon the load represented by the trays, the weight of the sheets of paper in the trays and the load balancing effect of a spring employed to assist in the lifting of the trays upwardly to engage the cam. The motor power is adjusted and controlled to reduce the applied motor force and speed dependent upon the load which must be overcome in either the upward or downward movement of the trays, for noise and wear reduction.Type: GrantFiled: September 27, 1993Date of Patent: September 20, 1994Assignee: Gradco (Japan) Ltd.Inventors: Peter M. Coombs, Bryson Bennett