Patents by Inventor Bunji Kageyama
Bunji Kageyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6103231Abstract: Novel antibiotic stalobacins H-1 and I-1 having physico-chemical properties as shown in Table 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.Type: GrantFiled: December 9, 1997Date of Patent: August 15, 2000Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Tadashi Yoshida, Ryuji Sakazaki, Koichi Matsumoto, Shigeo Yagi, Bunji Kageyama, Yoshimi Kawamura, Toshiyuki Kamigauchi, Susumu Kamata
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Patent number: 5686285Abstract: A norbornane type ester hydrolase that enantio-selectively hydrolyzes a (.+-.) -exo-norbornane type ester represented by Formula I is provided: ##STR1## wherein R is acyl, and A and B are hydrogens, respectively, or where A and B are absent, resulting in a carbon-carbon double bond between the carbons to which A and B are attached in Formula I. The norbornane type ester hydrolase has an optimal pH of approximately 8 and a stable pH range of approximately 6 to 8.Type: GrantFiled: June 1, 1995Date of Patent: November 11, 1997Assignee: Shionogi & Co., Ltd.Inventors: Bunji Kageyama, Masanori Nakae, Shigeo Yagi
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Patent number: 5484725Abstract: A norbornane type ester hydrolase that enantio-selectively hydrolyzes a (.+-.)-exo-norbornane type ester represented by Formula I is provided: ##STR1## wherein R is acyl, and A and B are hydrogens, respectively, or where A and B are absent, resulting in a carbon-carbon double bond between the carbons to which A and B are attached in Formula I. The norbornane type ester hydrolase has an optimal pH of approximately 8 and a stable pH range of approximately 6 to 8.Type: GrantFiled: April 22, 1994Date of Patent: January 16, 1996Assignee: Shionogi & Co., Ltd.Inventors: Bunji Kageyama, Masanori Nakae, Shigeo Yagi
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Patent number: 5459067Abstract: A method for producing an optically active norborneol is provided, which includes the step of bringing a microorganism or treated cells thereof into contact with (.+-.)-exo-norbornane type ester represented by Formula (I), wherein the microorganism is selected from the group consisting of the genus Pseudomonas, the genus Acetobacter, the genus Arthrobacter, the genus Rhodotorula, and the genus Saccharomyces. According to this method, (+)- and/or (-)-exo-norbornane type alcohol can be obtained with high yield and high purity by a simple treatment.Type: GrantFiled: August 5, 1993Date of Patent: October 17, 1995Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Bunji Kageyama, Masanori Nakae, Takayasu Sonoyama, Kyozo Kawata
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Patent number: 5456910Abstract: Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.Type: GrantFiled: May 17, 1994Date of Patent: October 10, 1995Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Tadashi Yoshida, Ryuji Sakazaki, Koichi Matsumoto, Shigeo Yagi, Bunji Kageyama, Yoshimi Kawamura, Toshiyuki Kamigauchi, Susumu Kamata
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Patent number: 5234819Abstract: 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possibly by simple contact of said microorganisms or their processed products therefrom, with D-glucose.Type: GrantFiled: February 12, 1992Date of Patent: August 10, 1993Assignee: Shiongi & Co., Ltd.Inventors: Takayasu Sonoyama, Shigeo Yagi, Bunji Kageyama, Masahiro Tanimoto
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Patent number: 5134077Abstract: 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possible by simple contact of said microorganisms or their processed products therefrom, with D-glucose.Type: GrantFiled: September 5, 1989Date of Patent: July 28, 1992Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Shigeo Yagi, Bunji Kageyama, Masahiro Tanimoto
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Patent number: 4879229Abstract: 2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of D-glucose. The production is also possible by simple contact of said microorganisms or their processed products therefrom, with D-glucose.Type: GrantFiled: September 12, 1988Date of Patent: November 7, 1989Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Shigeo Yagi, Bunji Kageyama, Masahiro Tanimoto
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Patent number: 4748122Abstract: A novel reductase is produced from a microorganism which belongs to genus Corynebacterium and is useful as a catalyst which catalizes, in the presence of NADPH, reduction of 2, 5-diketo-D-gluconic acid or its salts to 2-keto-L-gulonate or the corresponding salts thereof. It also catalizes reduction of 5-keto-D-fructose to sorbose, in the presence of NADPH.Type: GrantFiled: October 29, 1984Date of Patent: May 31, 1988Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Bunji Kageyama, Kobee Kobayashi, Masahiro Tanimoto
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Patent number: 4696897Abstract: 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on a medium containing D-glucose, employing two kinds of microorganisms; the first, a 2,5-diketo-D-gluconic acid producing microorganism which belongs to genus Erwinia and the second, a 2-keto-L-gulonic acid producing microorganism which belongs to genus Brevibacterium or Corynebacterium. The incubation of the microorganisms in a medium containing D-glucose is used in the disclosed process. By-production of 2-keto-D-gluconic acid, the undesired isomer of the intended product is effectively prevented by employing mixed culturing because of the co-existence of both microorganisms in the medium during at least part of the entire cultivation. Namely, 2-keto-D-gluconic acid produced by the second microorganism is utilized by the first microorganism to produce 2,5-diketo-D-gluconic acid which is subsequently converted into 2-keto-L-gulonic acid by the second microorganism.Type: GrantFiled: June 21, 1985Date of Patent: September 29, 1987Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Shigeo Yagi, Bunji Kageyama
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Patent number: 4543331Abstract: Fermentative or enzymatic production of 2-keto-L-gulonic acid from 2,5-diketo-D-gluconic acid using living or processed mutants, being defective in metabolizing 5-keto-D-gluconic acid and incapable of producing 2-keto-D-gluconic acid. The mutant is derived from 2-keto-L-gluconic acid producing microorganisms of genus Corynebacterium. The production is carried out in the presence of nitrates and/or hydrogen donors in a preliminarily sterilized fermentation broth in which a 2,5-diketo-D-gluconic acid producing microorganism of genus Gluconobacter or Erwinia has been cultivated.Type: GrantFiled: February 25, 1983Date of Patent: September 24, 1985Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Shigeo Yagi, Bunji Kageyama
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Patent number: 3998697Abstract: 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on or mixed contacting with a medium containing D-glucose, employing at least two kind of microorganisms; 2,5-diketo-D-gluconic acid producing strains which belong to the genera of Acetobacter, Acetomonas and Gluconobacter and strains capable of converting the 2,5-diketo-D-gluconic acid into 2-keto-L-gulonic acid which belong to the general of Brevibacterium and Corynebacterium. Both the incubation of the microorganisms in a medium containing D-glucose and the direct contact of any products obtained from the cells of the microorganisms with the substrate may be used in the disclosed process.Type: GrantFiled: April 21, 1975Date of Patent: December 21, 1976Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Hiroyoshi Tani, Bunji Kageyama, Kobee Kobayashi, Tahiko Honjo, Shigeo Yagi
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Patent number: 3963574Abstract: 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the species of the Brevibacterium nov. sp. ASM-856-4, ATCC 31083. The incubation of the microorganism in a medium containing 2,5-diketo-D-gluconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.Type: GrantFiled: March 21, 1975Date of Patent: June 15, 1976Inventors: Takayasu Sonoyama, Hiroyoshi Tani, Bunji Kageyama, Kobee Kobayashi, Tahiko Honjo, Shigeo Yagi
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Patent number: 3959076Abstract: 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the genus Corynebacterium. The incubation of the microorganism in a medium containing 2,5-diketo-D-gliconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.Type: GrantFiled: March 21, 1975Date of Patent: May 25, 1976Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Hiroyoshi Tani, Bunji Kageyama, Kobee Kobayashi, Tahiko Honjo, Shigeo Yagi
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Patent number: RE30872Abstract: 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism used for this microbial conversion includes strains which belong to genera of Brevibacterium, Arthrobacter, Micrococcus, Staphylococcus, Pseudomonas and Bacillus. Both the incubation of the microorganism in a medium containing 2,5-diketo-L-gluconic acid and the direct contact of any products obtained from the cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.Type: GrantFiled: January 22, 1980Date of Patent: February 23, 1982Assignee: Shionogi & Co., Ltd.Inventors: Takayasu Sonoyama, Bunji Kageyama, Tahiko Honjo