Abstract: Plasmon-integrated sensing mechanism comprised of three fundamental parts: a grating structure (2) with a specific metalization thickness (1) for the coupling of photons with the surface plasmons; a fluidic channel structure (4) in which liquid solutions with different refractive indexes will be streamed; and a photo-sensitive substrate (3) that can detect the light (8) which encounters changes in its intensity as the result of excitation of surface plasmons. The photo-sensitive substrate (3) may work according to photo-diode principle or it may work according to plasmon-assisted photo-resistor principle by using thin film amorphous carbon which exhibits resistance change sensitive to temperature.