Patents by Inventor Burkhard Kroger

Burkhard Kroger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of a fine chemical by fermentation
    Publication number: 20070134768
    Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 14, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner, Burkhard Kroger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
  • Gene coding for glucose-6-phosphate-dehydrogenase proteins
    Patent number: 7226762
    Abstract: The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced.
    Type: Grant
    Filed: November 11, 2002
    Date of Patent: June 5, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Markus Pompejus, Hartwig Schröder, Burkhard Kröger, Corinna Klopprogge, Gregor Haberhauer
  • Gene variants coding for proteins from the metabolic pathway of fine chemicals
    Publication number: 20070122887
    Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 31, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Corinna Klopprogge, Oskar Zelder, Burkhard Kroger, Hartwig Schroder, Stefan Haefner, Uwe Ruffer, Claudia Graef
  • Corynebacterium glutamicum genes encoding metabolic pathway proteins
    Publication number: 20070117183
    Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.
    Type: Application
    Filed: August 28, 2006
    Publication date: May 24, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins
    Publication number: 20070111290
    Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.
    Type: Application
    Filed: August 17, 2006
    Publication date: May 17, 2007
    Applicant: BASF AG
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation
    Publication number: 20070111232
    Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.
    Type: Application
    Filed: August 29, 2006
    Publication date: May 17, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
    Publication number: 20070111230
    Abstract: Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
    Type: Application
    Filed: August 18, 2006
    Publication date: May 17, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding novel proteins
    Publication number: 20070099213
    Abstract: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.
    Type: Application
    Filed: August 17, 2006
    Publication date: May 3, 2007
    Applicant: BASF AG
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
    Publication number: 20070082383
    Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
    Type: Application
    Filed: August 15, 2006
    Publication date: April 12, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Genes encoding genetic stability, gene expression and folding proteins
    Publication number: 20070077631
    Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
    Type: Application
    Filed: November 3, 2006
    Publication date: April 5, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Markus Pompejus, Hartwig Schroder, Burkhard Kroger, Corinna Klopprogge, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
    Publication number: 20070077622
    Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
    Type: Application
    Filed: August 15, 2006
    Publication date: April 5, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
    Publication number: 20070077576
    Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
    Type: Application
    Filed: August 22, 2006
    Publication date: April 5, 2007
    Applicant: BASF AG
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer, Heung-Shick Lee, Hyung-Joon Kim
  • Genes coding for metabolic pathway proteins
    Publication number: 20070072274
    Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
    Type: Application
    Filed: November 21, 2006
    Publication date: March 29, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Markus Pompejus, Hartwig Schroder, Burkhard Kroger, Corinna Klopprogge, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
    Publication number: 20070072265
    Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
    Type: Application
    Filed: August 15, 2006
    Publication date: March 29, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Genes encoding genetic stability, gene expression and folding proteins
    Publication number: 20070072273
    Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
    Type: Application
    Filed: November 2, 2006
    Publication date: March 29, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Markus Pompejus, Hartwig Schroder, Burkhard Kroger, Corinna Klopprogge, Gregor Haberhauer
  • Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
    Publication number: 20070065914
    Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
    Type: Application
    Filed: August 15, 2006
    Publication date: March 22, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer
  • Genes encoding carbon metabolism and energy-producing proteins
    Publication number: 20070065928
    Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
    Type: Application
    Filed: November 17, 2006
    Publication date: March 22, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Markus Pompejus, Hartwig Schroder, Burkhard Kroger, Corinna Klopprogge, Gregor Haberhauer
  • Use of the repressor glxR for the synthesis of lysine in
    Patent number: 7192749
    Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: March 20, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Corinna Klopprogge, Oskar Zelder, Burkhard Kröger, Hartwig Schröder, Stefan Häfner, Heung-Shick Lee
  • Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
    Publication number: 20070059810
    Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
    Type: Application
    Filed: August 22, 2006
    Publication date: March 15, 2007
    Applicant: BASF AG
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer, Heung-Shick Lee, Hyung-Joon Kim
  • Corynebacterium glutamicum genes encoding novel proteins
    Publication number: 20070059744
    Abstract: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.
    Type: Application
    Filed: August 17, 2006
    Publication date: March 15, 2007
    Applicant: BASF AG
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer