Patents by Inventor Byeong-Chun Lee
Byeong-Chun Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10717991Abstract: The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for ?-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.Type: GrantFiled: November 11, 2016Date of Patent: July 21, 2020Assignees: CHONG KUN DANG PHARMACEUTICAL CORP., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Byeong Chun Lee, Curie Ahn, Geon A Kim, Su Cheong Yeom, Su Jin Kim, Bumrae Cho, Eun Mi Lee, Sang Hoon Lee, In Chang Hwang, Hye Jin Hong
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Patent number: 10480076Abstract: A plasma enhanced chemical vapor deposition (PECVD) apparatus including a chamber; an upper electrode in the chamber; a spray unit in the upper electrode to spray a gas introduced from outside the chamber toward a substrate inside the chamber; a susceptor on which the substrate is mountable; a plurality of mask supports in a mask frame at an edge of the susceptor, the mask supports being formed of a conductive material that provides elastic force by supporting a mask to maintain and control a level of the mask; and a power supply unit to supply power to the upper electrode.Type: GrantFiled: February 22, 2016Date of Patent: November 19, 2019Assignee: Samsung Display Co., Ltd.Inventors: Jai Hyuk Choi, Won Woong Park, Sung Hun Key, Min Soo Kim, Byeong Chun Lee, Suk Won Jung, Hyun Woo Joo, Myung Soo Huh
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Publication number: 20190024115Abstract: The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for ?-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same. The transgenic pig of the present invention, in which the genes coding for human HO-1 and TNFR1-Fc fusion protein are simultaneously expressed and the gene coding for GGTA1 is knocked out, may reduce oxidative stress during organ isolation and in vitro culture by antioxidative reaction, cytoprotective function, etc., and may also reduce a TNF-?-mediated inflammatory response in early transplantation by TNFR1-Fc expression.Type: ApplicationFiled: November 11, 2016Publication date: January 24, 2019Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, CHONG KUN DANG PHARMACEUTICAL CORP.Inventors: Byeong Chun Lee, Cu Rie Ahn, Geon A Kim, Su Cheong Yeom, Su Jin Kim, Bum Rae Cho, Eun Mi Lee, Sang Hoon Lee, In Chang Hwang, Hye Jin Hong
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Publication number: 20170002468Abstract: A plasma enhanced chemical vapor deposition (PECVD) apparatus including a chamber; an upper electrode in the chamber; a spray unit in the upper electrode to spray a gas introduced from outside the chamber toward a substrate inside the chamber; a susceptor on which the substrate is mountable; a plurality of mask supports in a mask frame at an edge of the susceptor, the mask supports being formed of a conductive material that provides elastic force by supporting a mask to maintain and control a level of the mask; and a power supply unit to supply power to the upper electrode.Type: ApplicationFiled: February 22, 2016Publication date: January 5, 2017Inventors: Jai Hyuk CHOI, Won Woong PARK, Sung Hun KEY, Min Soo KIM, Byeong Chun LEE, Suk Won JUNG, Hyun Woo JOO, Myung Soo HUH
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Patent number: 9476064Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: GrantFiled: November 26, 2013Date of Patent: October 25, 2016Assignee: H BION CO., LTD.Inventors: Sung-Il Roh, Woo-Suk Hwang, Byeong-Chun Lee, Sung-Keun Kang, Young-June Ryu, Eu-Gene Lee, Soon-Woong Kim, Dae-Kee Kwon, Hee-Sun Kwon, Ja-Min Koo, Eul-Soon Park, Youn-Young Hwang, Hyun-Soo Yoon, Jong-Hyuk Park, Sun-Jong Kim
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Patent number: 9357754Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.Type: GrantFiled: January 20, 2012Date of Patent: June 7, 2016Assignee: SNU R&DB FOUNDATIONInventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon
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Patent number: 9018439Abstract: The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.Type: GrantFiled: December 21, 2010Date of Patent: April 28, 2015Assignee: Hanwha Advanced Materials CorporationInventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Goo Jang, Bum Rae Cho, Ok Jae Koo, Jung Taek Kang, Dae Kee Kwon
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Patent number: 8940836Abstract: A polycarbonate resin composition can have improved transparency and scratch resistance of the present invention and comprises about 10 to about 99% by weight of polycarbonate resin (A); and about 1 to about 90% by weight of acrylic copolymer with ultra-low molecular weight and high refractive index (B). The resin composition of the present invention can further comprise acrylic resin (C). The acrylic copolymer with ultra-low molecular weight and high refractive index (B) can have a refractive index of about 1.495 to about 1.590 and a weight average molecular weight of about 3,000 to about 40,000 g/mol.Type: GrantFiled: December 4, 2009Date of Patent: January 27, 2015Assignee: Cheil Industries Inc.Inventors: Kee Hae Kwon, Il Jin Kim, Jin Hwa Chung, Sang Ki Park, Ja Kwan Koo, Bok Nam Jang, Jin Hwan Choi, Tae Uk Kim, Byeong Chun Lee
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Publication number: 20140154800Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: ApplicationFiled: November 26, 2013Publication date: June 5, 2014Applicant: H. Bion Co., Ltd.Inventors: Sung-Il ROH, Woo-Suk HWANG, Byeong-Chun LEE, Sung-Keun KANG, Young-June RYU, Eu-Gene LEE, Soon-Woong KIM, Dae-Kee KWON, Hee-Sun KWON, Ja-Min KOO, Eul-Soon PARK, Youn-Young HWANG, Hyun-SOO YOON, Jong-Hyuk PARK, Sun-Jong KIM
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Patent number: 8647872Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: GrantFiled: December 9, 2011Date of Patent: February 11, 2014Assignee: H. Bion Co., Ltd.Inventors: Sung-Il Roh, Woo-Suk Hwang, Byeong-Chun Lee, Sung-Keun Kang, Young-June Ryu, Eu-Gene Lee, Soon-Woong Kim, Dae-Kee Kwon, Hee-Sun Kwon, Ja-Min Koo, Eul-Soon Park, Youn-Young Hwang, Hyun-Soo Yoon, Jong-Hyuk Park, Sun-Jong Kim
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Publication number: 20140026233Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.Type: ApplicationFiled: January 20, 2012Publication date: January 23, 2014Applicant: SNU R&DB FOUNDATIONInventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon
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Publication number: 20120278910Abstract: The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.Type: ApplicationFiled: December 21, 2010Publication date: November 1, 2012Applicant: HANWHA L&C CORPORATIONInventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Goo Jang, Bum Rae Cho, Ok Jae Koo, Jung Taek Kang, Dae Kee Kwon
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Publication number: 20120083032Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: ApplicationFiled: December 9, 2011Publication date: April 5, 2012Applicant: H. BION CO., LTD.Inventors: Sung-Il ROH, Woo-Suk HWANG, Byeong-Chun LEE, Sung-Keun KANG, Young-June RYU, Eu-Gene LEE, Soon-Woong KIM, Dae-Kee KWON, Hee-Sun KWON, Ja-Min KOO, Eul-Soon PARK, Youn-Young HWANG, Hyun-Soo YOON, Jong-Hyuk PARK, Sun-Jong KIM
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Patent number: 8124832Abstract: Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.Type: GrantFiled: June 13, 2007Date of Patent: February 28, 2012Assignee: Seoul National University Industry FoundationInventors: Byeong Chun Lee, Sung Keun Kang, Dae Yong Kim, Min Kyu Kim, Goo Jang, Hyun Ju Oh, M. Shamim Hossein, Fibrianto Yuda, Hye Jin Kim, So Gun Hong, Jung Eun Park, Joung Joo Kim
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Publication number: 20110065192Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: ApplicationFiled: November 20, 2009Publication date: March 17, 2011Applicant: H Bion Co., Ltd.Inventors: Sung-II Roh, Woo-Suk Hwang, Byeong-Chun Lee, Sung-Keun Kang, Young-June Ryu, Eu-Gene Lee, Soon-Woong Kim, Dae-Kee Kwon, Hee-Sun Kwon, Ja-Min Koo, Eul-Soon Park, Youn-Young Hwang, Hyun-Soo Yoon, Jong-Hyuk Park, Sun-Jong Kim
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Publication number: 20100293626Abstract: The present invention relates to a method for increasing the efficiency of offspring production in producing animals belonging to the family Canidae (canines) by somatic cell nuclear transfer. More specifically, relates to a method for increasing the efficiency of production of cloned canines by a method for cloning canines comprising enucleating the oocyte of a canine to prepare an enucleated oocyte, fusing a nuclear donor cell with the enucleated oocyte to prepare a nuclear transfer embryo and transferring the nuclear transfer embryo into the oviduct of a surrogate mother, wherein the nuclear donor cell is cultured in a medium containing a specific cell cycle synchronization-inducing substance such as roscovitine in the preparation thereof.Type: ApplicationFiled: November 19, 2008Publication date: November 18, 2010Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATIONInventors: Byeong Chun Lee, Min Kyu Kim, Goo Jang, Hyun Ju Oh, So Gun Hong, Jung Eun Park, Jung Taek Kang
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Publication number: 20100287635Abstract: Disclosed herein are a cloned canine and a production method thereof. The method comprises the steps of enucleating the oocyte of a canine to prepare an enucleated recipient oocyte, conducting nuclear transfer into the enucleated oocyte using a canine somatic cell as a nuclear donor cell under optimized conditions so as to prepare a nuclear transfer embryo, and transferring the nuclear transfer embryo into the oviduct of a surrogate mother. The present invention provides a method for producing cloned canines and thus, can contribute to the development of studies in veterinary medicine, anthropology and medical science such as the propagation of superior canines, the conservation of rare or nearly extinct canines, xenotransplantation and disease animal models.Type: ApplicationFiled: July 26, 2006Publication date: November 11, 2010Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATIONInventors: Woo Suk Hwang, Byeong Chun Lee, Sung Keun Kang, Min Kyu Kim, Goo Jang, Hyun Ju Oh, Hye Jin Kim, Joung Ju Kim, Shamim Hossein Mohammad, Heru Fibrianto Yuda
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Publication number: 20100152357Abstract: A polycarbonate resin composition can have improved transparency and scratch resistance of the present invention and comprises about 10 to about 99% by weight of polycarbonate resin (A); and about 1 to about 90% by weight of acrylic copolymer with ultra-low molecular weight and high refractive index (B). The resin composition of the present invention can further comprise acrylic resin (C). The acrylic copolymer with ultra-low molecular weight and high refractive index (B) can have a refractive index of about 1.495 to about 1.590 and a weight average molecular weight of about 3,000 to about 40,000 g/mol.Type: ApplicationFiled: December 4, 2009Publication date: June 17, 2010Applicant: CHEIL INDUSTRIES INC.Inventors: Kee Hae KWON, Il Jin KIM, Jin Hwa CHUNG, Sang Ki PARK, Ja Kwan KOO, Bok Nam JANG, Jin Hwan CHOI, Tae Uk KIM, Byeong Chun LEE
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Publication number: 20080295191Abstract: Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother. The method has the effect of producing a cloned dog with high efficiency, and thus can contribute to the development of studies in veterinary medicine, anthropology and medical science, such as the propagation of superior species, xenotransplantation and diseased animal models. In addition, the present invention has the effect of exactly researching production properties of the cloned dog by producing a female cloned dog for the first time, rather than the conventional male cloned dog.Type: ApplicationFiled: June 13, 2007Publication date: November 27, 2008Inventors: Byeong Chun Lee, Sung Keun Kang, Dae Yong Kim, Min Kyu Kim, Goo Jang, Hyun Ju Oh, M. Shamim Hossein, Fibrianto Yuda, Hye Jin Kim, So Gun Hong, Jung Eun Park, Joung Joo Kim
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Publication number: 20070243610Abstract: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.Type: ApplicationFiled: December 30, 2004Publication date: October 18, 2007Applicant: Seoul National University Industry FoundationInventors: Sung-Il Roh, Woo-Suk Hwang, Byeong-Chun Lee, Sung-Keun Kang, Young-June Ryu, Eu-Gene Lee, Soon-Woong Kim, Dae-Kee Kwon, Hee-Sun Kwon, Ja-Min Koo, Eul-Soon Park, Youn-Young Hwang, Hyun-Soo Yoon, Jong-Hyuk Park, Sun-Jong Kim