Abstract: Disclosed is a method for producing a fluorine-18-labeled, translocator protein overexpression-targeting PET radiotracer including: preparing a fluorine-18 reaction solution; producing a ((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl) (aryl)iodonium) anion precursor as an iodonium salt precursor; producing a 2-(6,8-dichloro-2-(4-(4,4,5,6-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazo[1,2-a]pyridin-3-yl-N,N-dipropylacetamide precursor as a boron ester precursor; producing an iodonium salt precursor reaction solution; preparing a boron ester precursor reaction solution; and producing a radiotracer composition containing a fluorine-18-labeled radiotracer by reacting the iodonium salt or boron ester precursor reaction solution with the fluorine-18-labeled reaction solution.

Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

Abstract: Provided is a capacitive micromachined ultrasonic transducer (CMUT) including a substrate, a top electrode provided on the substrate to be spaced apart from the substrate, a supporter made of an insulating material and coupled between the substrate and an edge of the top electrode to support and fix the edge of the top electrode and to define a gap between the substrate and the edge of the top electrode, and a plurality of nanoposts having both ends coupled and fixed to the substrate and the top electrode in the gap, and being compressible and stretchable in a longitudinal direction to at least vertically move the top electrode when power is applied to the top electrode.

Abstract: A DNA polymerase in which a mutation is induced at a specific amino acid position to increase gene mutation specificity, a nucleic acid sequence encoding the polymerase, a vector comprising the nucleic acid sequence, and a host cell transformed with the vector are disclosed. Provided are a method for in vitro detecting one or more gene mutations or SNPs in one or more templates by using a DNA polymerase having increased gene mutation specificity, a composition for detecting a gene mutation or SNP comprising the DNA polymerase, and a PCR kit comprising said composition. Furthermore, provided are a PCR buffer composition for increasing the activity of a DNA polymerase having increased gene mutation specificity and a PCR kit for detecting a gene mutation or SNP comprising the PCR buffer composition and/or the DNA polymerase having increased gene mutation specificity.

Abstract: Disclosed herein is a non-invasive treatment system using intermedium, and an exemplary treatment system is configured to output high-intensity focused ultrasound to remove bone tissue, inject an acoustically-transparent medium into a part where the bone tissue is removed to generate an intermedium, and output therapeutic ultrasound that passes through the intermedium. Accordingly, the bone tissue is removed in a non-invasive way using high-intensity focused ultrasound, and the intermedium is generated at the bone tissue removed site, to increase the penetration of therapeutic ultrasound or generate ultrasound itself, thereby improving an ultrasound treatment effect while minimizing the side effect (for example, infection of dura mater) of invasive surgery methods.

Abstract: The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.

Abstract: According to an embodiment of the present disclosure, there is provided a completely new type of 3-dimensional (3D) printing method for producing an object by focusing ultrasound onto material that changes in state by stimulation to solidify it into a desired shape. The method for 3D printing according to an embodiment includes providing material which changes in state by stimulation, setting a target focal point in the material, focusing ultrasound onto the target focal point using at least one ultrasound transducer, and applying stimulation to the material using the focused ultrasound to induce a change in state of the material. According to the embodiments, it is possible to control the precision of the output by controlling the frequency of the ultrasound transducer or the size of the target focal point on system.

Abstract: A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

Abstract: A coolant control valve includes a cam rotating by rotational force; a pivot arm disposed under the cam, one end of the pivot arm moving in an up and down direction by rotation of the cam; a valve installed at another end of the pivot arm and disposed outside an outer diameter of the cam, the valve moving as the pivot arm moves; and a pivot arm support hinge for supporting the pivot arm and enabling vertical movement of the pivot arm when the cam rotates.

Abstract: A membrane device includes a trench substrate having trenches and a membrane having wrinkles. The membrane is not bonded to the trenches of the trench substrate but is bonded to the surface of the trench substrate in the shoulders of the trenches. Hills and valleys are alternately arranged in the membrane along the trenches. The membrane device can be used in various applications (for example, sensors) based on variations in the electrical properties of the membrane caused by a change in the shape of the wrinkles (a change in the strain) of the membrane in response to a change in the internal or external environment of the trenches.

Abstract: Disclosed herein is an aerosol generating and mixing system operating at a high temperature and a high pressure which includes an aerosol generating device; and an aerosol mixing device, wherein the aerosol generating device includes a pre-mixing tank and a mixing tank, and the mixing tank and the pre-mixing tank include a wing configured to rotate about a central shaft of the tank so as to agitate an inside aerosol, and an agitating motor configured to rotate the wing, and a filling nozzle of the mixing tank and the pre-mixing tank is configured to inject any of an aerosol aqueous solution and an aerosol particle.

Abstract: An engine oil supply system may include an oil pan connected with an oil pump at a first side and connected with an oil cooler at a second side, an oil passage through which oil pressurized by the oil pump flows, an oil filter disposed in the oil pan to filter impurities in the oil supplied from the oil pump, and a bypass valve disposed in the oil passage to selectively supply the oil in the oil passage to at least one of the oil cooler and the oil filter.

Abstract: A flow accelerating ventilation type head cover may include a baffle separating a lower space which is opened such that blow-by gas containing an oil particle generated from an engine is collected thereto and an upper space which is closed such that the blow-by gas is flowed out to an outside of the engine and having a baffle passage communicating the lower space with the upper space such that the blow-by gas is exhausted from the lower space to the upper space therethrough, and a flow accelerating member being coupled with the baffle passage and being positioned in the upper space so as to accelerate a flow speed of the blow-by gas passing through the baffle passage and thus separate the oil particle by collision effect of impacting the oil particle with each other in the upper space.

Abstract: A coolant control valve includes a cam rotating by rotational force; a pivot arm disposed under the cam, one end of the pivot arm moving in an up and down direction by rotation of the cam; a valve installed at another end of the pivot arm and disposed outside an outer diameter of the cam, the valve moving as the pivot arm moves; and a pivot arm support hinge for supporting the pivot arm and enabling vertical movement of the pivot arm when the cam rotates.

Abstract: A flow accelerating ventilation type head cover may include a baffle separating a lower space which is opened such that blow-by gas containing an oil particle generated from an engine is collected thereto and an upper space which is closed such that the blow-by gas is flowed out to an outside of the engine and having a baffle passage communicating the lower space with the upper space such that the blow-by gas is exhausted from the lower space to the upper space therethrough, and a flow accelerating member being coupled with the baffle passage and being positioned in the upper space so as to accelerate a flow speed of the blow-by gas passing through the baffle passage and thus separate the oil particle by collision effect of impacting the oil particle with each other in the upper space.

Abstract: Disclosed herein is an aerosol generating and mixing system operating at a high temperature and a high pressure which includes an aerosol generating device; and an aerosol mixing device, wherein the aerosol generating device includes a pre-mixing tank and a mixing tank, and the mixing tank and the pre-mixing tank include a wing configured to rotate about a central shaft of the tank so as to agitate an inside aerosol, and an agitating motor configured to rotate the wing, and a filling nozzle of the mixing tank and the pre-mixing tank is configured to inject any of an aerosol aqueous solution and an aerosol particle.

Abstract: The present invention relates to an aerosol sampling system operating at a high temperature and pressure, and in particular to a system which is able to sample and analyze an aerosol. The present invention aims to provide a system which is able to carry out measurements, for example, a sampling, an analysis, etc. at a high temperature and pressure, which was unavailable in the past since there is not any aerosol measuring system to sample and analyze at a high temperature and pressure.

Abstract: An engine oil supply system may include an oil pan connected with an oil pump at a first side and connected with an oil cooler at a second side, an oil passage through which oil pressurized by the oil pump flows, an oil filter disposed in the oil pan to filter impurities in the oil supplied from the oil pump, and a bypass valve disposed in the oil passage to selectively supply the oil in the oil passage to at least one of the oil cooler and the oil filter.

Abstract: Disclosed are an [18F]fluoromethyl group-introduced radiotracer for brain neuroinflammation-targeting positron emission tomography (PET), the synthesis thereof, and a method for evaluating biological results using the same. In the method for the synthesis of an [18F]fluoromethyl group-introduced radiotracer for brain neuroinflammation-targeting positron emission tomography, a compound obtained by introducing triazolium triflate into normethyl-PBR28 is used as a precursor and a fluoromethyl group is labeled with fluorine-18 in a single step. The [18F]fluoromethyl group-introduced radiotracer for brain neuroinflammation-targeting positron emission tomography is synthesized by using a compound, obtained by introducing triazolium triflate into normethyl-PBR28, as a precursor and performing substitution with fluorine-18 in a single step.

Abstract: The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.