Patents by Inventor Byung-Heon Lee
Byung-Heon Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120316101Abstract: The present invention relates to a polypeptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to an isolated polypeptide consisting of the sequence (I): Cys-X1-Val-Ala-Pro-X2 (I), wherein X1 is an amino acid with polar uncharged side chain and X2 is an amino acid with positive charged side chain and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. Accordingly, the peptide of the present invention may be useful for detection of apoptotic cells, as well as detection and imaging of apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue and arteriosclerosis site, and targeted drug delivery thereto.Type: ApplicationFiled: May 9, 2012Publication date: December 13, 2012Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Byung Heon Lee, In San Kim
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Publication number: 20120294931Abstract: The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors.Type: ApplicationFiled: December 29, 2010Publication date: November 22, 2012Applicants: Kyungpook National University Industry-Academic Cooperation Foundation, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: In San Kim, Byung Heon Lee, Maggie JM Lu, Hsiang-Fa Liang, Yi-ju Ko, Ya-Chin Lo, Li-Wen Chang, Ming-Cheng Wei
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Publication number: 20120288447Abstract: The present invention relates to a peptide that passes through a blood-brain barrier and targets apoptosis of neurodegenerative brain disease-affected sites and uses thereof. More particularly, the present invention relates to a composition for delivering drugs to brain tissues, a composition for detecting apoptotic cells of neurodegenerative brain disease-affected sites, and a composition for imaging the neurodegenerative brain disease-affected sites which comprises a peptide having an amino acid sequence represented by SEQ ID: No. 1 respectively, and a composition for prevention, treatment, or theranosis of neurodegenerative brain diseases comprising said peptide. The peptide of the present invention can be used for detecting apoptosis in neurodegenerative brain diseases and further detecting apoptotic cells (especially apoptotic neuronal cells) in neurodegenerative brain disease-affected sites and imaging, targeted drug delivery, theranosis.Type: ApplicationFiled: May 11, 2012Publication date: November 15, 2012Applicant: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Byung-Heon Lee, In San Kim, Jae-Sung Bae, Hee Kyoung Jin, Hyung Soo Han
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Publication number: 20120258038Abstract: The present invention relates to a composition for preventing, treating or theranosis of apoptosis-related diseases comprising liposome comprising apoptotic cell-targeting peptides, label substances and a therapeutic agent. The present invention may be used for drug delivery to the apoptotic cells in cancer or tumor mass, the apoptotic myocardial cells in myocardial infarction lesion, the apoptotic stroke cells in stroke lesion, the apoptotic cells in arteriosclerosis lesion and further may be used for detection of the cells and imaging diagnosis. Therefore, it can be used for theranosis as well as preventing or treating the diseases.Type: ApplicationFiled: May 11, 2012Publication date: October 11, 2012Applicant: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Byung-Heon Lee, In San Kim, Yu Kyoung Oh
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Patent number: 8217012Abstract: A peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof is described. Peptides having an amino acid sequence represented by any one of SEQ ID NO: 1 to SEQ ID NO: 12 targeted apoptotic cell. Uses for compositions comprising the peptides include detection of apoptotic cells drug delivery and imaging. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be bound to an imaging or treatment reagent to be used in diagnosis of diseases, imaging of drug reactions, and treatment for diseases by selective drug delivery.Type: GrantFiled: May 13, 2009Date of Patent: July 10, 2012Assignee: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Byung Heon Lee, In San Kim
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Patent number: 8133971Abstract: The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine.Type: GrantFiled: February 24, 2009Date of Patent: March 13, 2012Assignee: Kyungpook National University Industry Academic Cooperation FoundationInventors: Byung-Heon Lee, In-San Kim, Thapa Narendra
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Patent number: 7968081Abstract: A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide effectively targets atherosclerotic plaques, and binds to IL-4R to thereby exhibit antagonistic effects on IL-4-mediated signaling of cellular inflammatory reaction and survival reaction. The peptide of the present invention can be used for diagnosis of atherosclerosis, prevention and treatment of IL-4-induced inflammatory reaction and prevention and treatment of atherosclerosis which is primarily caused by the inflammatory reaction, as well as for prevention or treatment of atherosclerosis via conjugation with an anti-atherosclerotic drug.Type: GrantFiled: January 18, 2008Date of Patent: June 28, 2011Assignee: Kyungpook National University Industry—Academic Cooperation FoundationInventors: Byung Heon Lee, In San Kim, Hai Yan Hong, In Seop So
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Publication number: 20110150764Abstract: The present invention relates to stroke-targeting peptides and use thereof. More specifically, the present invention relates to a stroke-targeting peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 4 and use thereof. The peptide of the present invention can be specifically bound to stroke cells in the subject, and thus can be effectively used in diagnostic markers and kits for stroke, and compositions for drug delivery specific to stroke and pharmaceutical compositions and compositions for imaging stroke.Type: ApplicationFiled: June 2, 2009Publication date: June 23, 2011Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY- ACADEMIC COOPERATION FOUNDATIONInventors: Byung-Heon Lee, In San Kim, Hyung Soo Han, Jeong Soo Yoo
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Patent number: 7919464Abstract: The present invention relates to the use of a peptide that interacts with the ?v?3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.Type: GrantFiled: April 2, 2004Date of Patent: April 5, 2011Assignee: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Ju-Ock Nam, Jung-Eun Kim, Ha-Won Jeong, Sung-Jin Lee, Byung-Heon Lee, Je-Yong Choi, Rang-Woon Park, Jae-Yong Park, In-San Kim
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Patent number: 7745410Abstract: The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.Type: GrantFiled: November 6, 2007Date of Patent: June 29, 2010Assignees: Kyungpook National University Industry-Academica Cooperation Foundation, Burnham Institute for Medical ResearchInventors: Erkki Ruoslahti, Byung-Heon Lee, In-San Kim
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Publication number: 20090285754Abstract: The present invention relates to a peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to a peptide having an amino acid sequence represented by anyone selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 12 and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be used in imaging of diagnosis of the said diseases and reaction against a drug by binding imaging reagent and etc.Type: ApplicationFiled: May 13, 2009Publication date: November 19, 2009Applicant: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Byung Heon Lee, In San Kim
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Publication number: 20090214430Abstract: The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine.Type: ApplicationFiled: February 24, 2009Publication date: August 27, 2009Applicant: Kyungpook National University Industry-Academic Cooperation FoundationInventors: Byung-Heon LEE, In-San KIM, Thapa NARENDRA
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Publication number: 20090074663Abstract: A peptide for diagnosing, preventing and treating atherosclerosis, and a use thereof, comprising an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and a use thereof. The peptide effectively targets atherosclerotic plaques, and binds to IL-4R to thereby exhibit antagonistic effects on IL-4-mediated signaling of cellular inflammatory reaction and survival reaction. The peptide of the present invention can be used for diagnosis of atherosclerosis, prevention and treatment of IL-4-induced inflammatory reaction and prevention and treatment of atherosclerosis which is primarily caused by the inflammatory reaction, as well as for prevention or treatment of atherosclerosis via conjugation with an anti-atherosclerotic drug.Type: ApplicationFiled: January 18, 2008Publication date: March 19, 2009Inventors: Byung Heon Lee, In San Kim, Hai Yan Hong, In Seop So
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Publication number: 20080274955Abstract: The present invention relates to the novel use of a polypeptide comprising a fas-1 domain. More particularly, the invention relates to a method for the inhibition of the adhesion, migration and/or proliferation of endothelial cells, and/or for the inhibition of angiogenesis, using the polypeptide comprising the fas-1 domain, or functional equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the polypeptide.Type: ApplicationFiled: April 13, 2004Publication date: November 6, 2008Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Ju-Ock Nam, Jung-Eun Kim, Ha-Won Jeong, Sung-Jin Lee, Byung-Heon Lee, Je-Yong Choi, Rang-Woon Park, Jae-Yong Park, In-San Kim
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Publication number: 20080139479Abstract: The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.Type: ApplicationFiled: November 6, 2007Publication date: June 12, 2008Applicants: Kyungpook National University Industry-Academic Cooperation Foundation, Burnham Institute for Medical ResearchInventors: Erkki Ruoslahti, Byung-Heon Lee, In-San Kim
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Publication number: 20070167369Abstract: The present invention relates to the novel use of a polypeptide comprising an isolated polypeptide comprising EMI domain, four fas-1 domains and RGD motif of ?ig-h3. More particularly, the invention relates to a method for the inhibition of the adhesion, migration and/or proliferation of endothelial cells, and/or for the inhibition of angiogenesis, using the isolated polypeptide comprising EMI domain, four fas-1 domains and RGD motif of ?ig-h3, or functional equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the polypeptide.Type: ApplicationFiled: March 1, 2007Publication date: July 19, 2007Applicant: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Ju-Ock Nam, Jung-Eun Kim, Ha-Won Jeong, Sung-Jin Lee, Byung-Heon Lee, Je-Yong Choi, Rang-Woon Park, Jae-Yong Park, In-San Kim, Hye-Nam Son
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Patent number: 6650374Abstract: The present invention relates to a digital television relay system for relaying wirelessly a broadcasting signal discharged from a broadcasting station. In order to cover shadow areas of the digital broadcasting channel signal discharged from a digital television transmitter, the present invention receives the broadcasting channel signal of a certain frequency discharged from the broadcasting station, performs channel-decoding, compensates a transmission error occurred in space, and relays it wirelessly to a subscriber in the shadow areas. Accordingly, the present invention can provide a digital television broadcasting service with transmission quality same with the broadcasting station to the subscriber in the shadow areas.Type: GrantFiled: December 19, 2000Date of Patent: November 18, 2003Assignee: LG Electronics Inc.Inventors: Kwang-Joo Choi, Seong-Hwan Oh, Cheol Lee, Byung-Heon Lee
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Publication number: 20010005234Abstract: The present invention relates to a digital television relay system for relaying wirelessly a broadcasting signal discharged from a broadcasting station. In order to cover shadow areas of the digital broadcasting channel signal discharged from a digital television transmitter, the present invention receives the broadcasting channel signal of a certain frequency discharged from the broadcasting station, performs channel-decoding, compensates a transmission error occurred in space, and relays it wirelessly to a subscriber in the shadow areas. Accordingly, the present invention can provide a digital television broadcasting service with transmission quality same with the broadcasting station to the subscriber in the shadow areas.Type: ApplicationFiled: December 19, 2000Publication date: June 28, 2001Applicant: LG Electronics Inc.Inventors: Kwang-Joo Choi, Seong-Hwan Oh, Cheol Lee, Byung-Heon Lee