Patents by Inventor C. Cheng
C. Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240190892Abstract: The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.Type: ApplicationFiled: March 16, 2022Publication date: June 13, 2024Applicant: Merck Sharp & Dohme LLCInventors: Natalija Cernaka, Anthony K. Ogawa, Alan C. Cheng, Jianming Bao, Phillip Patrick Sharp, Jovan Alexander Lopez, Dong Xiao, Haiqun Tang
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Patent number: 11931151Abstract: Disclosed herein is an automated urinary output measuring system. The automated urinary output measuring system includes an automated urinary output measuring device configured to be suspended from a rim of a sanitary hardware device and receive a volume of voided urine. The automated urinary output measuring device can include a receiving trough having an opening, a door configured to cover the opening in a fluid tight seal, the door coupled to the receiving trough by a hinge, and a lip extending from the receiving trough configured to detachably couple the automated urinary output measuring device to the sanitary hardware device. The system can further include an ultrasonic measuring system having a console coupled to one or more ultrasonic sensors, and a flushing mechanism coupled to the sanitary hardware device.Type: GrantFiled: December 20, 2021Date of Patent: March 19, 2024Assignee: C. R. Bard, Inc.Inventors: Jason Jishen Cheng, Trevor Dimicco, Audrey Earnshaw, Juan C. Tapia
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Publication number: 20240043491Abstract: Provided herein are IL-2 muteins that bind to IL-2 receptor subunit but do not have measurable binding to IL-2 receptor subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.Type: ApplicationFiled: December 21, 2021Publication date: February 8, 2024Applicant: MERCK SHARP & DOHME LLCInventors: Stephen E. ALVES, Glareh AZADI, Maribel BEAUMONT, Lia BENSO, Alan C. CHENG, Peter GEORGIEV, Brian E. HALL, Veronica M. JUAN, Renee MOORE, Venkataraman SRIRAMAN, Jie ZHANG-HOOVER
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Publication number: 20240025917Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.Type: ApplicationFiled: November 18, 2021Publication date: January 25, 2024Applicant: Merck Sharp & Dohme LLCInventors: Jianming Bao, Natalija Cernaka, Alan C. Cheng, Ying-Duo Gao, Salman Jabri, Jovan Alexander Lopez, Rohan Merchant, Anthony Ken Ogawa, Skylar K. Osler, Christopher J. Sinz, Phillip Patrick Sharp, Haiqun Tang, Maoqun Tian, Dong Xiao, Song Yang
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Publication number: 20230416227Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.Type: ApplicationFiled: September 9, 2021Publication date: December 28, 2023Applicant: Merck Sharp & Dohme LLCInventors: Anthony Ken Ogawa, Christopher J. Sinz, Jacqueline D. Hicks, Alan C. Cheng, Song Yang, Jianming Bao, Donna A. A. W. Hayes, Simon B. Lang, Maoqun Tian, Salman Jabri, Galen Paul Shearn-Nance, Rongze Kuang, Zhiqiang Zhao, Zhicai Wu
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Publication number: 20230352118Abstract: A computer-implemented method is disclosed for candidate antibody exploration. The method includes receiving sequence reads from a sequencing system, wherein each sequence read comprises a target gene for expressing a candidate antibody, wherein each sequence read is associated with a binding affinity to a target antigen. The method includes generating a sequence representation for each sequence read, representing the amino acid sequences of the sequence read. The method includes training a binding affinity prediction model with the sequence representations and the binding affinities. The method includes generating a synthetic candidate sequence read that is different from the sequence reads. The method includes generating a sequence representation for the synthetic candidate sequence read.Type: ApplicationFiled: May 2, 2023Publication date: November 2, 2023Inventors: Yara Seif, Xiao Xiao, Kevin Teng, Ming-Tang Chen, Alan C. Cheng, BoRam Lee, Isha Verma
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Publication number: 20230348428Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.Type: ApplicationFiled: July 6, 2021Publication date: November 2, 2023Applicant: Merck Sharp & Dohme LLCInventors: Jacqueline D. HICKS, Rongze Kuang, Christopher J. Sinz, Matthew J. Lombardo, Jovan Alexander Lopez, Rohan Rajiv Merchant, Phillip Patrick Sharp, Zhicai Wu, Zhiqiang Zhao, Alan C. Cheng, Song Yang, Jianming Bao, Maoqun Tian, Galen Paul Shearn-Nance
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Patent number: 11793858Abstract: Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.Type: GrantFiled: April 15, 2019Date of Patent: October 24, 2023Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: C. Cheng Kao, Antonio Cembellin Prieto, Dean Rowe-Magnus
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Publication number: 20230286958Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.Type: ApplicationFiled: June 10, 2021Publication date: September 14, 2023Applicant: Merck Sharp & Dohme LLCInventors: Salman Jabri, Anthony Ken Ogawa, Christopher J. Sinz, Jacqueline D. Hicks, Alan C. Cheng, Ying-Duo Gao, Song Yang, Jianming Bao, Donna A. A. W. Hayes, Simon B. Lang, Brandon M. Taoka, Maoqun Tian, Galen Paul Shearn-Nance, Rongze Kuang, Matthew J. Lombardo, Zhicai Wu, Zhiqiang Zhao
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Publication number: 20230272056Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.Type: ApplicationFiled: April 8, 2021Publication date: August 31, 2023Applicant: Merck Sharp & Dohme LLCInventors: Chung-Ming Hsieh, Michelle Castor, Ming-Tang Chen, Alan C. Cheng, Scott A. Hollingsworth, Veronica M. Juan, Madhura Shidhore, Song Yang, Renee C.T. Moore
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Publication number: 20230265175Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.Type: ApplicationFiled: June 23, 2021Publication date: August 24, 2023Applicant: Merck Sharp & Dohme LLCInventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
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Patent number: 11702467Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.Type: GrantFiled: June 23, 2021Date of Patent: July 18, 2023Assignee: Merck Sharp & Dohme LLCInventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
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Publication number: 20230167168Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.Type: ApplicationFiled: June 23, 2021Publication date: June 1, 2023Applicant: Merck Sharp & Dohme Corp.Inventors: Jeanne E. Baker, Sophie Parmentier Batteur, Ming-Tang Chen, Alan C. Cheng, Chung-Ming Hsieh, Carl Mieczkowski, Sokreine Suon
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Publication number: 20230141928Abstract: Machine-learning (ML) techniques and models are described for predicting the number and severity of network attacks within a specified timeframe, such as the next fifteen minutes. In some embodiments, the techniques including training a ML model based on features extracted from a training dataset and applying the trained ML model to estimate (a) the probability of an attack happening on an account within a specified timeframe; (b) how many attacks are predicted to occur in the specified timeframe (if any); and/or (c) the severity of the attacks predicted to occur. A system may deploy preventative measures based on the ML model output to counter or mitigate the effects of predicted and coordinated network attacks.Type: ApplicationFiled: October 13, 2021Publication date: May 11, 2023Applicant: Oracle International CorporationInventors: Ján Sterba, Venkatakrishnan Gopalakrishnan, May Bich Nhi Lam, Yunjiao Xue, Nana Lei, Edward C. Cheng, Hayward Ivan Craig Welcher, Jacob Becker West, Qi Wen Cao
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Publication number: 20230134546Abstract: Machine-learning techniques and models are described for alerting users to attacks on accounts in real-time or near real-time. In some embodiments, an attack detection model uses Natural Language Processing (NLP) and multi-level classification techniques to monitor login attempts and detect attacks. The model may use NLP to convert text associated with account activity to numerical vectors, where the vectors include scores and/or other numerical values computed based on the meaning of the converted text. The model may further include a set of classifiers trained to learn patterns in the numerical vectors that are predictive of a network attack. The model may assign labels to events based on the predicted likelihood that the event is an attack. The system may deploy real-time preventative or corrective measures based on the ML model output to counter or mitigate the effects of an attack.Type: ApplicationFiled: October 29, 2021Publication date: May 4, 2023Applicant: Oracle International CorporationInventors: Venkatakrishnan Gopalakrishnan, Ján Sterba, May Bich Nhi Lam, Yunjiao Xue, Nana Lei, Edward C. Cheng, Hayward Ivan Craig Welcher, Jacob Becker West, Qi Wen Cao
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Publication number: 20230052348Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.Type: ApplicationFiled: October 14, 2021Publication date: February 16, 2023Applicant: AMGEN INC.Inventors: Sean P BROWN, David Karl BEDKE, Michael R. DEGRAFFENREID, Jiasheng FU, Zhinghong LI, Felix GONZALEZ LOPEZ DE TURISO, Ana GONZALEZ BUENROSTRO, Michael W. GRIBBLE JR., Michael G. JOHNSON, Todd J. KOHN, Kexue LI, Yunxiao LI, Mike Elias LIZARZABURU, Yosup REW, Joshua TAYGERLY, Yingcai WANG, Xuelei YAN, Ming YU, Jiang ZHU, Manuel ZANCANELLA, Xian Yun JIAO, Liusheng ZHU, Xianghong WANG, Julio C. MEDINA, Jason A. DUQUETTE, Jonathan B. HOUZE, Marc VIMOLRATANA, Mario G. CARDOZO, Alan C. CHENG
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Publication number: 20230037593Abstract: A poroelastic biomaterial including a polyaryletherketone (PAEK) matrix polymer and a plurality of tortuous channels extending from one surface to another surface of the biomaterial is disclosed. Advantageously, the poroelastic biomaterial can have a porosity from about 5% to about 40% and high mechanical properties. The poroelastic biomaterials can be fabricated into orthopedic implant devices and can be used as a tissue scaffolds.Type: ApplicationFiled: July 26, 2022Publication date: February 9, 2023Inventors: Tim HSU, Minren LIN, Saadyah AVERICK, Boyle C. CHENG
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Patent number: 11429574Abstract: Disclosed embodiments provide a computer-implemented technique for creating a log chain from multiple software component logs. The log chain can include log information from multiple software components that interact with each other. In embodiments, a locality-sensitive hashing technique is used to create a signature of a log chain. Machine-learning systems are trained with log chains generated from test execution, and/or log chains from incidents with deployed software. In embodiments, logs are pre-processed by tokenizing and trimming. Logs from various components that interact with each other may be combined into a temporally sequential log chain. The signature of the log chain may be used to identify additional information about the error from a machine-learning process that was trained on previously generated log chains. In this way, the time required to identify a problem can be significantly reduced, resulting in increased reliability and availability of complex computer systems.Type: GrantFiled: April 3, 2020Date of Patent: August 30, 2022Assignee: International Business Machines CorporationInventors: Quan Q C Cheng, Xiang Qiu, Zhi Wei Du, Peng Hui Jiang
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Patent number: 11306107Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.Type: GrantFiled: February 24, 2017Date of Patent: April 19, 2022Assignee: AMGEN INC.Inventors: Sean P. Brown, David Karl Bedke, Michael R. Degraffenreid, Jiasheng Fu, Zhihong Li, Felix Gonzalez Lopez De Turiso, Ana Gonzalez Buenrostro, Michael W. Gribble, Jr., Michael G. Johnson, Todd J. Kohn, Kexue Li, Yunxiao Li, Mike Elias Lizarzaburu, Yosup Rew, Joshua Taygerly, Yingcai Wang, Xuelei Yan, Ming Yu, Jiang Zhu, Manuel Zancanella, Xian Yun Jiao, Liusheng Zhu, Xianghong Wang, Julio C. Medina, Jason A. Duquette, Jonathan B. Houze, Marc Vimolratana, Mario G. Cardozo, Alan C. Cheng
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Patent number: D1025075Type: GrantFiled: July 11, 2022Date of Patent: April 30, 2024Assignee: Apple Inc.Inventors: Jody Akana, Molly Anderson, Bartley K. Andre, Shota Aoyagi, Anthony Michael Ashcroft, Marine C. Bataille, Jeremy Bataillou, Eric Wesley Bates, Mu-Hua Cheng, Sawyer Isaac Cohen, Markus Diebel, Richard Hung Minh Dinh, M. Evans Hankey, Julian Hoenig, Richard P. Howarth, Jonathan P. Ive, Julian Jaede, Hugh J. Jay, Duncan Robert Kerr, Peter Russell-Clarke, Benjamin Andrew Shaffer, Mikael Silvanto, Sung-Ho Tan, Clement Tissandier, Eugene Antony Whang, Rico Zörkendörfer