Patents by Inventor C. Edgar Cook

C. Edgar Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 17?-amino and hydroxylamino-11 ?-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 7018991
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: March 28, 2006
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6864248
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: March 8, 2005
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17&bgr;-acyl-17&agr;-propynyl-11&bgr;-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
    Patent number: 6740645
    Abstract: The invention is directed to a novel class of 17&bgr;-acyl-17&agr;-propynyl steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: May 25, 2004
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Jill M. O'Reilly
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20040097477
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Applicant: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17 Beta-amino and hydroxylamino-11 beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Publication number: 20040023936
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Application
    Filed: July 2, 2003
    Publication date: February 5, 2004
    Applicant: RESEARCHTRIANGLE INSTITUTE
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6670352
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 30, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6620801
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: September 16, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20020103177
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: January 22, 2002
    Publication date: August 1, 2002
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17beta-amino and hydroxylamino-11beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Publication number: 20020065257
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Application
    Filed: July 2, 2001
    Publication date: May 30, 2002
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6369047
    Abstract: An androgenic steroid compound of the formula: wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: April 9, 2002
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • ANDROGENIC STEROID COMPOUNDS AND A METHOD OF MAKING AND USING THE SAME
    Publication number: 20020002156
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: June 9, 1999
    Publication date: January 3, 2002
    Inventors: C. EDGAR COOK, JOHN A. KEPLER, YUE-WEI LEE, MANSUKH C. WANI
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6262042
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: July 17, 2001
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley
  • 17&bgr;-acyl-17&agr;-propynyl-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6172052
    Abstract: The invention is directed to a novel class of 17&bgr;-acyl-17&bgr;-propynyl steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: January 9, 2001
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Jill M. O'Reilly
  • 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6093707
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 25, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • 11.beta.-aryl-17, 17-spirothiolane-substituted steroids
    Patent number: 6043235
    Abstract: The invention is directed to 11.beta.-aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using and process of making the compounds.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: March 28, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Rupa S. Shetty, John A. Kepler, David Y.-W. Lee
  • 20-keto-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6020328
    Abstract: The invention is directed to 20-keto-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.9, R.sup.12 and X are as defined by the specification. The compounds exhibit progestational and antiprogestational activities.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: February 1, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Ping-sheng Zhang, Yue-wei Lee, C. Ray Tallent
  • 17.beta.-nitro-11.beta.-arylisteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6015805
    Abstract: The invention is directed to 11.beta.-arylsteroids of formula II: ##STR1## wherein R.sup.1, R.sup.6, R.sup.8, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: January 18, 2000
    Assignee: Research Triangle Research North Carolina
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 5962444
    Abstract: The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: October 5, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • Hexahydroindenopyridine compounds having antispermatogenic activity
    Patent number: 5952336
    Abstract: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Joseph M. Jump, Pingsheng Zhang, John R. Stephens, Patricia A. Fail, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 5952319
    Abstract: An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are as defined herein.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani