Abstract: In various embodiments, a surgical instrument can comprise an end effector including a staple cartridge and a datum portion positioned proximal to the staple cartridge. The surgical instrument can further comprise a shaft and an articulation joint configured to articulate the end effector relative to the shaft. In addition, the surgical instrument can further comprise a firing member configured to deploy a plurality of staples from the staple cartridge and a drive assembly including a drive member configured to move the firing member. The drive assembly may also include a stop configured to engage the datum portion to limit the movement of the drive member after the plurality of staples are fired.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Anodine receptor type 2 (RyR2) inhibitors and methods of their use in the treatment of cardiac conditions.

Abstract: Steering responses for a lean-to-steer device can be provided by controlling the steering angle of at least one wheel by a steering actuator that is operated by a controller. The controller receives signals that are indicative to the current operating conditions and adjusts the steering angle for at least one wheel responsive to the signals.

Abstract: A processor for supporting secure memory intent is disclosed. The processor of the disclosure includes a memory execution unit to access memory and a processor core coupled to the memory execution unit. The processor core is to receive a request to access a convertible page of the memory. In response to the request, the processor core to determine an intent for the convertible page in view of a page table entry (PTE) corresponding to the convertible page. The intent indicates whether the convertible page is to be accessed as at least one of a secure page or a non-secure page.

Abstract: Provided are a computer program product, system, and method for a data set connection manager having a plurality of data sets to represent one data set. A request is processed to open a connection to a data set having members, wherein the connection is used to perform read and write requests to the members in the data set. In response to establishing the connection, establishing for the connection a primary data set having all the members; a secondary data set to which updated members in the primary data set are written; and a pending delete data set to pending delete members comprising members that are updated.

Abstract: Described herein are pumps that linearly reciprocate to assist with circulating blood within the body of a patient. Red blood cell damage may be avoided or minimized by such linear pump movement. The linearly reciprocating movement may also generate a pulsatile pumping cycle that mimics the natural pumping cycle of the heart. The pumps may be configured to reside at various body locations. For example, the pumps may be situated within the right ventricle, the left ventricle, the ascending aorta, the descending aorta, the thoracic aorta, or the abdominal aorta. In some instances, the pump may reside outside the patient.

Abstract: A device to determine density includes a housing, a first transducer disposed in the housing at a first position, and a second transducer disposed in the housing at a second position. The second transducer is located a distance from the first transducer. The device also includes a controller that reads a first output from the first transducer, and reads a second output from the second transducer. The controller determines a density of a liquid based on the first output, the second output, and the distance.

Abstract: A single-use handle is configured to attach to a working shaft that can support a sounder for measuring the medullary canal of a proximal radius, and a planarizer that is configured to planarize a proximal edge of the proximal radius after the proximal radius has been resected. The handle can further include a plurality of sizing cavities that are configured to receive the resected bone so as to determine the size of the resected bone. The handle can further include an ejector that is configured to decouple the planarizer from the working shaft.

Abstract: A lock module comprising a housing, a lock pawl, and an actuator. The lock pawl may be moveable between an extended position and a retracted position, wherein the lock pawl extends from the housing by a greater distance in the extended position than in the retracted position. The actuator may be configured to selectively couple to the lock pawl, the lock module being in a locked configuration when the actuator is coupled to the lock pawl. The lock pawl may be configured to move in a first direction as a closure moves from a first position to a second position and the lock pawl may be configured to move in a second direction as the closure moves from the second position to the first position. The first direction may be opposite the second direction. The lock pawl may be configured to block movement of the closure when the lock module is in the locked configuration.

Abstract: The present disclosure generally relates to apparatus, software and methods for thwarting radio spoofing techniques by requiring and sending data from multiple radios positioned such that the receiving client can determine that it came from multiple spatially separated radios due to the Angle of Arrival of each radio's signal.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: A septic tank system includes a multiple compartmented (or chambered) supplemental tank. The supplemental tank has a cover/lid with a plurality of strategically situated access holes (both small and large ports) for servicing the various chambers from above ground.

Abstract: A method includes controlling an additive manufacturing system to fabricate a 3D structure using successive layers of material. The additive manufacturing system includes a build platform having a first region, second region, and overlapping third region between the first and second regions; and multiple sources configured to build (e.g., deposit, bond, melt, solidify) the successive layers of material in the regions of the build platform. Controlling the additive manufacturing system includes controlling the additive manufacturing system to build first, second, and third portions of the 3D structure within the regions of the build platform. Each portion of the 3D structure includes (i) one or more test features that are common to the portions of the 3D structure and (ii) a substrate onto or into which the one or more common test features are formed.

Abstract: A variety of illumination devices are disclosed that are configured to manipulate light provided by one or more light-emitting elements (LEEs). In general, embodiments of the illumination devices feature one or more optical couplers that redirect illumination from the LEEs to a reflector which then directs the light into a range of angles. In some embodiments, the illumination device includes a second reflector that reflects at least some of the light from the first reflector. In certain embodiments, the illumination device includes a light guide that guides light from the collector to the first reflector. The components of the illumination device can be configured to provide illumination devices that can provide a variety of intensity distributions. Such illumination devices can be configured to provide light for particular lighting applications, including office lighting, task lighting, cabinet lighting, garage lighting, wall wash, stack lighting, and downlighting.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: Processes for producing n-heptane from a mixture of 1-hexene and 1-octene in the presence of a suitable isomerization-metathesis catalyst followed by a hydrogenation step are disclosed. Integrated manufacturing systems for producing n-heptane with minimal waste also are disclosed.

Abstract: Apparatus and methods are disclosed for controlling execution of memory access instructions in a block-based processor architecture using a hardware structure that generates a relative ordering of memory access instruction in an instruction block. In one example of the disclosed technology, a method of executing an instruction block having a plurality of memory load and/or memory store instructions includes decoding an instruction block encoding a plurality of memory access instructions and generating data indicating a relative order for executing the memory access instructions in the instruction block and scheduling operation of a portion of the instruction block based at least in part on the relative order data. In some examples, a store vector data register can store the generated relative ordering data for use in subsequent instances of the instruction block.

Abstract: An inventory management system provides automated management of medical item inventory and maintenance of a digital chain of custody for medical items. Medical items are labeled with an RFID-encoded tag that also displays a 2D barcode. The RFID tag and the 2D barcode both encode the same serialized Electronic Product Code (EPC) data for each specific item. Reading of the RFID tag is performed using a fixed or handheld RFID reader. Reading of the 2D barcode is performed using a handheld mobile device, such as a tablet or smart phone. The two-technology label allows for the digital chain of custody to be updated by means of RFID scanning in locations where RFID readers are available and by using a smart phone or tablet to read the 2D barcode in locations where RFID readers are unavailable.