Patents by Inventor California Institute of Technology

California Institute of Technology has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130279631
    Abstract: A method for sending a data from an electromagnetic radiator by polarization modulation of an electromagnetic wave includes radiating from the radiator first and second electromagnetic waves including first and second polarizations respectively, the first polarization being different than the second polarization. The first and second electromagnetic waves form a third electromagnetic wave having a third polarization different from the first or second polarization. The method includes modulating the third polarization responsive to the data by modulating one or more parts of the third electromagnetic wave. The data is sent in the third polarization. A system for sending a data includes an oscillator adapted to generate an oscillating signal, and a phase shifter coupled to the oscillator and adapted to generate a first phase-shifted oscillating signal having a first phase. The phase shifter is adapted to vary the phase difference across a predefined range in response to the data.
    Type: Application
    Filed: February 19, 2013
    Publication date: October 24, 2013
    Inventor: California Institute of Technology
  • Publication number: 20130273626
    Abstract: Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydroxylates octane primarily at the 2-positio to form S-2-octanol (40% ee). Another mutant, 1-12G, hydroxylates alkanes larger than hexane primarily at the 2-position, but forms R-2-alcohols (40-55% ee). These biocatalysts are highly active for alkane substrates and support thousands of product turnovers. These regio- and enantio-selectivities are retained in whole-cell biotransformations with E. coli, where the engineered P450s can be expressed at high levels and the expensive cofactor is supplied endogenously.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 17, 2013
    Inventor: The California Institute of Technology
  • Publication number: 20130249598
    Abstract: Systems and methods in accordance with embodiments of the invention implement microscale digital vacuum electronic gates. In one embodiment, a microscale digital vacuum electronic gate includes: a microscale field emitter that can emit electrons and that is a microscale cathode; and a microscale anode; where the microscale field emitter and the microscale anode are disposed within at least a partial vacuum; where the microscale field emitter and the microscale anode are separated by a gap; and where the potential difference between the microscale field emitter and the microscale anode is controllable such that the flow of electrons between the microscale field emitter and the microscale anode is thereby controllable; where when the microscale anode receives a flow of electrons, a first logic state is defined; and where when the microscale anode does not receive a flow of electrons, a second logic state is defined.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 26, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130220729
    Abstract: A tensegrity apparatus having multiple tensegrity units for the transmission of solitary waves with adjustable profiles into a material or structure, and the detection of such waves from a material or structure.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 29, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Publication number: 20130224550
    Abstract: Systems and methods in accordance with embodiments of the invention implement a lithium-based high energy density flow battery. In one embodiment, a lithium-based high energy density flow battery includes a first anodic conductive solution that includes a lithium polyaromatic hydrocarbon complex dissolved in a solvent, a second cathodic conductive solution that includes a cathodic complex dissolved in a solvent, a solid lithium ion conductor disposed so as to separate the first solution from the second solution, such that the first conductive solution, the second conductive solution, and the solid lithium ionic conductor define a circuit, where when the circuit is closed, lithium from the lithium polyaromatic hydrocarbon complex in the first conductive solution dissociates from the lithium polyaromatic hydrocarbon complex, migrates through the solid lithium ionic conductor, and associates with the cathodic complex of the second conductive solution, and a current is generated.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 29, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130222115
    Abstract: An autonomous and controllable system of sensors and methods for using such a system of sensors are described.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 29, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: California Institute Of Technology
  • Publication number: 20130213860
    Abstract: A method is provided for changing a property of a sample. A sample, comprising particles suspended within a sample fluid, is introduced into a channel which comprises two walls that are permeable to a flow of fluid. A cross-flow is introduced at a predetermined temperature and of a predetermined chemical composition into the channel through a wall. This cross-flow flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. The imposed field causes the particles to migrate at a second velocity opposite and/or equal to the first velocity of the cross-flow. Particles that are approximately balanced by the first and second velocities travel through the channel and are discharged in a fluid of predetermined chemical composition and at the predetermined temperature of the cross-flow.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 22, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Publication number: 20130213462
    Abstract: A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconducting material having a photocatalyst such as nickel or nickel-molybdenum coated on the material. The photoelectrode includes an elongated axially integrated wire having at least two different wire compositions.
    Type: Application
    Filed: February 20, 2013
    Publication date: August 22, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: California Institute of Technology
  • Publication number: 20130213881
    Abstract: Described herein are filtration membranes and related, compositions, methods and systems and in particular filtration membranes with embedded polymeric micro/nanoparticles and related compositions, methods, and systems.
    Type: Application
    Filed: January 30, 2013
    Publication date: August 22, 2013
    Applicants: Korea Advanced Institute of Science and Technology, California Institute of Technology
    Inventors: California Institute of Technology, Korea Advanced Institute of Science and Technology
  • Publication number: 20130213861
    Abstract: A radial opposed migration classifier is provided for separating particles in a sample, introducing and removing the particles into and out of the classifier at the same potential. A sample passes through a classification channel having two circular walls. The sample is introduced and exits the classifier through the same plane as the first wall, which is at a different potential from the second wall. A cross-flow fluid enters the classification channel through one of the walls. The cross-flow fluid flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. This causes the particles of a desired size and/or charge to migrate at a second velocity opposite and/or equal to a first velocity of the cross-flow. The particles that travel through the channel are discharged.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 22, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: California Institute of Technology
  • Publication number: 20130209454
    Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) antibodies having improved potency and breadth.
    Type: Application
    Filed: December 13, 2012
    Publication date: August 15, 2013
    Applicants: THE ROCKEFELLER UNIVERSITY, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE ROCKEFELLER UNIVERSITY
  • Publication number: 20130209448
    Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
    Type: Application
    Filed: March 28, 2013
    Publication date: August 15, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130211012
    Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
    Type: Application
    Filed: March 28, 2013
    Publication date: August 15, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130210646
    Abstract: Described microfluidic technology focused on: 1) direct integration of microfluidic devices with solidified liquid tissue samples, 2) subordination of architectural and operational principles of microfluidic devices specific tissue structure and needs and/or 3) on-chip sample acquisition integrated with the detection measurement within the same device. In contrast to conventional methods of off-chip sample prep and subsequent insertion into a detection device, new applications are possible on solidified liquid or solid tissue samples, such as in situ PCR.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 15, 2013
    Applicants: California Institute of Technology, University of Southern California
    Inventors: University of Southern California, California Institute of Technology
  • Publication number: 20130207639
    Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 15, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130210080
    Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 15, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Publication number: 20130210073
    Abstract: The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs.
    Type: Application
    Filed: December 28, 2012
    Publication date: August 15, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Publication number: 20130201058
    Abstract: A method, system, and apparatus provide the ability to estimate ionospheric observables using space-borne observations. Space-borne global positioning system (GPS) data of ionospheric delay are obtained from a satellite. The space-borne GPS data are combined with ground-based GPS observations. The combination is utilized in a model to estimate a global three-dimensional (3D) electron density field.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 8, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Publication number: 20130188194
    Abstract: Hybrid sensors comprising Shack-Hartmann Wavefront Sensor (S-HWFS) and Zernike Wavefront Sensor (Z-WFS) capabilities are presented. The hybrid sensor includes a Z-WFS optically arranged in-line with a S-HWFS such that the combined wavefront sensor operates across a wide dynamic range and noise conditions. The Z-WFS may include the ability to introduce a dynamic phase shift in both transmissive and reflective modes.
    Type: Application
    Filed: January 22, 2013
    Publication date: July 25, 2013
    Applicant: California Institute of Technology
    Inventor: California Institute of Technology
  • Publication number: 20130187094
    Abstract: Granular crystals with one or more chains of particles are described. A geometry of at least one particle is chosen to provide highly nonlinear pulses having selected characteristics. Contact interactions between the particles are non-Hertzian.
    Type: Application
    Filed: February 13, 2013
    Publication date: July 25, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY