Patents by Inventor Calvin Bruce Harley
Calvin Bruce Harley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20180280413Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: October 13, 2017Publication date: October 4, 2018Applicant: Telomerase Activation Sciences, Inc.Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
-
Patent number: 9913851Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: GrantFiled: December 10, 2015Date of Patent: March 13, 2018Assignee: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
-
Publication number: 20160318973Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: December 10, 2015Publication date: November 3, 2016Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
-
Patent number: 9403866Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: GrantFiled: July 8, 2013Date of Patent: August 2, 2016Assignee: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
-
Publication number: 20150093455Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: June 24, 2014Publication date: April 2, 2015Inventors: Calvin Bruce HARLEY, Allison C. CHIN, Tsutomu AKAMA, Nancy Yuk-Yu IP, Yung-Hou WONG, David M. MILLER-MARTINI
-
Patent number: 8759304Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: GrantFiled: March 5, 2010Date of Patent: June 24, 2014Assignee: Telomerase Activation Science, Inc.Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
-
Publication number: 20140088055Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: July 8, 2013Publication date: March 27, 2014Applicant: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
-
Publication number: 20110071095Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: March 5, 2010Publication date: March 24, 2011Applicant: Geron CorporationInventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
-
Patent number: 7846904Abstract: The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: GrantFiled: June 23, 2004Date of Patent: December 7, 2010Assignee: Geron CorporationInventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
-
Publication number: 20080113925Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: June 23, 2004Publication date: May 15, 2008Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Wong Yung-hou, David M. Miller-Martini
-
Patent number: 5891639Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: June 18, 1998Date of Patent: April 6, 1999Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
-
Patent number: 5863726Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: April 12, 1996Date of Patent: January 26, 1999Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
-
Patent number: 5840490Abstract: Methods for detecting hematologic and colorectal malignancies are provided comprising: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the presence of telomerase activity with the presence of cancer cells. A method for staging leukemia is also provided comprising analyzing a blood or bone marrow sample for telomerase activity, correlating the activity with a standard level of telomerase activity, and correlating a low telomerase activity with early stage leukemia.Type: GrantFiled: June 7, 1995Date of Patent: November 24, 1998Assignee: McMaster UniversityInventors: Silvia Bacchetti, Christopher M. Counter, Brian Leber, Calvin Bruce Harley
-
Patent number: 5837453Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
-
Patent number: 5804380Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: April 15, 1996Date of Patent: September 8, 1998Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich