Abstract: A method including applying a first target-subject-specific model associated with a target subject to a treatment planning image to generate a transformed treatment planning image corresponding to a first position of a plurality of positions. The method also includes modifying one or more hyper-parameters of the first target-subject-specific model to generate a second target-subject-specific model corresponding to a second position of the plurality of positions. The method further includes controlling a radiation treatment delivery device based on the second target-subject-specific model to deliver a radiation treatment to the target subject.

Abstract: A method of sequential monoscopic tracking is described. The method includes generating a plurality of projections of an internal target region within a body of a patient, the plurality of projections comprising projection data about a position of an internal target region of the patient. The method further includes generating external positional data about external motion of the body of the patient using one or more external sensors. The method further includes generating, by a processing device, a correlation model between the projection data and the external positional data by fitting the plurality of projections of the internal target region to the external positional data. The method further includes estimating the position of the internal target region at a later time using the correlation model.

Abstract: A method and apparatus for treatment planning using four dimensional imaging data.

Abstract: A method of sequential monoscopic tracking is described. The method includes generating a plurality of projections of an internal target region within a body of a patient, the plurality of projections comprising projection data about a position of an internal target region of the patient. The method further includes generating external positional data about external motion of the body of the patient using one or more external sensors. The method further includes generating, by a processing device, a correlation model between the projection data and the external positional data by fitting the plurality of projections of the internal target region to the external positional data. The method further includes estimating the position of the internal target region at a later time using the correlation model.

Abstract: A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

Abstract: A treatment couch with a localization array is described.

Abstract: A method of and apparatus for operating a radiation treatment delivery system. The method includes generating, by a processing device, a set of instructions for a volumetric imager based on a set of directionalities for a radiation beam of a linear accelerator (LINAC) to avoid a collision between the volumetric imager and the LINAC, wherein the set of instructions comprises physical locations of the volumetric imager and timing values corresponding to the physical locations. The method further includes operating the volumetric imager during the radiation treatment delivery according to the set of instructions.

Abstract: A radiotherapy delivery device is provided. The device includes a source of therapeutic radiation and a first detector positioned to receive radiation from the source of therapeutic radiation. The device also includes a source of imaging radiation and a second detector positioned to receive radiation from the source of imaging radiation. A collimator assembly is positioned relative to the second source of radiation to selectively control a shape of a radiation beam emitted by the second radiation source to selectively expose part or the whole of the second radiation detector. A reconstruction processor can be operatively coupled to the detector and configured to generate patient images based on radiation received by the second detector from the second source of radiation. The device is configured to move from one imaging geometry to another using all or part of the second detector.

Abstract: A method of operating a localization array. The method includes providing the localization array in substantially an optimal position. The method also includes maintaining the localization array at substantially the optimal position by controlling movement of the localization array.

Abstract: A method includes receiving, from a volumetric imager, a first image including a target of a patient. The method further includes receiving a second image including the target of the patient. The method further includes tracking, by a processing device, a position of the target using the first image and the second image by maintaining a fixed alignment between a treatment beam of a linear accelerator (LINAC) and a source and detector pair of the volumetric imager during operation of the LINAC.

Abstract: Localization array position determination in a treatment room coordinate system is described. A method may include imaging, using an imaging system, a position of one or more markers integrated with a localization array in a treatment room and transforming the position of the one or more markers to a treatment room coordinate system. The method also includes determining the position of the localization array in the treatment room coordinate system based on the transforming.

Abstract: An x-ray imaging apparatus and associated methods are provided to receive measured projection data from a wide aperture scan of a wide axial region and a narrow aperture scan of a narrow axial region within the wide axial region and determine an estimated scatter in the wide axial region using an optimized scatter estimation technique. The optimized scatter estimation technique is based on the difference between the measured scatter in the narrow axial region and the estimated scatter in the narrow axial region. Kernel-based scatter estimation/correction techniques can be fitted to minimize the scatter difference in the narrow axial region and thereafter applying the fitted (optimized) kernel-based scatter estimation/correction to the wide axial region. Optimizations can occur in the projection data domain or the reconstruction domain. Iterative processes are also utilized.

Abstract: An imaging apparatus and associated methods are provided to efficiently estimate scatter during multi-fraction treatments for improved quality and workflow. Estimated scatter from one fraction during a treatment course can be utilized during subsequent fractions, allowing for measurements with higher scatter-to-primary ratios. The quality of scatter estimates can be maintained, while workflow improves and dosage decreases. Scan configuration limits can be utilized to maintain a minimum level of scatter measurement quality. Patient information can be monitored to ensure that prior fraction scatter estimates are still applicable to current patient status.

Abstract: A method of and apparatus for operating a radiation treatment delivery system. The method includes generating, by a processing device, a set of instructions for a volumetric imager based on a set of directionalities for a radiation beam of a linear accelerator (LINAC) to avoid a collision between the volumetric imager and the LINAC, wherein the set of instructions comprises physical locations of the volumetric imager and timing values corresponding to the physical locations. The method further includes operating the volumetric imager during the radiation treatment delivery according to the set of instructions.

Abstract: A method includes determining a first set of positions for a volumetric imager and determining a second set of positions for a linear accelerator (LINAC), during radiation treatment delivery. The method further includes determining a set of radiation beam directionalities of the LINAC, wherein for each of the second set of positions for the LINAC a radiation beam corresponds to a radiation beam directionality. The method further includes generating instructions for the volumetric imager based on the first and the second set of positions, the radiation beam directionalities, and a treatment time constraint to avoid a collision between the volumetric imager and the LINAC and between the volumetric imager and the radiation beam, wherein the instructions include physical locations of the volumetric imager and timing values corresponding to the physical locations. The method further includes operating the volumetric imager during the radiation treatment delivery according to the set of instructions.

Abstract: A method includes receiving, from a volumetric imager, a first image including a target of a patient. The method further includes receiving a second image including the target of the patient. The method further includes tracking, by a processing device, a position of the target using the first image and the second image by maintaining a fixed alignment between a treatment beam of a linear accelerator (LINAC) and a source and detector pair of the volumetric imager during operation of the LINAC.

Abstract: A reference image of a patient may be generated. A subsequent x-ray image of the patient may be generated after the generating of the reference image where the subsequent x-ray image is associated with a low dosage. A difference between the reference image and the subsequent x-ray image that is associated with the low dosage may be determined. A motion of the patient may be identified as having occurred based on the determined difference.

Abstract: A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

Abstract: A method includes receiving, from a volumetric imager, a first image including a target of a patient. The method further includes receiving a second image including the target of the patient. The method further includes tracking, by a processing device, a position of the target using the first image and the second image.

Abstract: A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.