Abstract: A subject of the invention is the compounds of formula (I): wherein R1, R2, R3, R?3, R4, R?4, R5, R6 and R7 are as described in the application, in the form of enantiomers or mixtures, as well as their salts with acids and bases, their preparation and their application as anti-bacterials, in both human and veterinary medicine.

Abstract: A subject of the invention is the compounds of formula (I): in which either R1 represents H, OH, NH2, —(CH2)m—NRaRb(m=0.1 or 2), Ra and Rb represent H, linear, branched or cyclic (C1-C6) alkyl, (C3-C6) cycloalkyl-(C3-C6)— alkyl, Rc, S(O)2Rc, C(O)Rc, S(O)2Rd or C(O)Rd; or Ra and Rb with N form an Rc radical; Rc represents a saturated, unsaturated or 5- or 6-members aromatic ring, containing 1 to 4 heteroatoms chosen from N, O and S, optionally substituted; Rd represents a linear, branched or cyclic (C1-C6) alkyl, optionally substituted by 1 to 4 halogens; or R1 represents Rc or CHReRc or CHReRd; Re represents H, OH, NH2, NH—(C1-C6)-alk or N-(C1-C6)-alk2, or NH—(C1-C7)-acyl or NHRc; R2 represents H, (CH2)m—NRaRb, Rc, CHReRc or CHReRd, and R?2 represents H.

Abstract: A subject of the invention is the compounds of formula (I): wherein R1, R2, R3, R?3, R4, R?4, R5, R6 and R7 are as described in the application, in the form of enantiomers or mixtures, as well as their salts with acids and bases, their preparation and their application as anti-bacterials, in both human and veterinary medicine.

Abstract: A subject of the invention is the compounds of formula (I): in which either R1 represents H, OH, NH2, —(CH2)m—NRaRb(m=0.

Abstract: The present invention relates to pyridazine derivatives of formula: ##STR1## which are useful as ligands of cholinergic receptors, in particular, receptors of the M.sub.1 type.

Abstract: The invention concerns compounds of the formula I: ##STR1## in which R.sub.1 to R.sub.5 are as defined in claim 1. These compounds find their application in the treatment of pathologies involving CRF.

Abstract: The invention relates to the derivatives of formula I: ##STR1## in which R.sub.1 represents a phenyl or naphthyl radical (optionally substituted), R.sub.2 represents a hydrogen or halogen atom or an alkyl, hydroxymethyl or formyl radical, R.sub.3 represents an alkyl, cycloalkyl, alkenyl, cycloalkylalkyl or phenyl radical, R.sub.4 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl radical, R.sub.5 represents an alkyl, cycloalkyl, cycloalkylalkyl or alkenyl radical or a radical of formula B: ##STR2## (p=0, 1, 2 or 3), R.sub.6 represents a phenyl, pyridyl, imidazolyl, pyrrolyl, thienyl or furyl radical, optionally substituted, or a cycloalkyl radical,m and n, which may be identical or different, each represent 0 or 1,their possible stereoisomers and their addition salts.

Abstract: The present invention relates to pyridazine derivatives of formula: ##STR1## which are useful as ligands of cholinergic receptors, in particular, receptors of the M.sub.1 type.

Abstract: The invention relates to 3-aminopyridazine derivatives.These compounds have the formula ##STR1## in which: R.sub.V is a linear or branched C.sub.1 -C.sub.4 alkyl group;R.sub.6 is hydrogen, a C.sub.1 -C.sub.3 alkoxy or a hydroxyl group; andZ is a group ##STR2## in which: n.sub.1 and n.sub.2 independently are zero or one,Y.sub.1 and Y.sub.2 independently are hydrogen or a C.sub.1 -C.sub.3 alkyl group, andT is a dialkylamino group in which the alkyls are C.sub.1 -C.sub.3, if Y.sub.1 or Y.sub.2 is other than hydrogen, or T is a heterocycle selected from: ##STR3## Application: drugs active on the central nervous system.

Abstract: The invention relates to the use of 5-alkylpyridazine derivatives of the formula ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.2 and R.sub.3 independently are a C.sub.1 -C.sub.4 alkyl group, or R.sub.2 and R.sub.3, taken with the nitrogen atom to which they are bonded, form a morpholino group, or one of their pharmaceutically acceptable salts, for the preparation of pharmaceutical compositions for combating pathological conditions associated with a cortical cholinergic deficiency, especially for the treatment of degenerative syndromes associated with senescence.

Abstract: The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors.These derivatives have the formula ##STR1## in which X=O, S, --OCH.sub.2 -- or --SCH.sub.2 --; R.sub.1 =H or halogen; and R.sub.2 = ##STR2## in which Alk is an alkylene group and R.sub.3, an R.sub.4, which are identical or different, are hydrogen or a lower alkyl group, or R.sub.3 and R.sub.4, with the nitrogen atom to which they are bonded, form a 5- or 6-membered cyclic amino group optionally containing a second heteroatom; or R.sub.2 is a group ##STR3## where R.sub.5 =C.sub.1 -C.sub.4 -alkyl. Application: agonists of cholinergic receptors.

Abstract: The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors and to drugs containing them.These derivatives have the following formula: ##STR1## in which: X represents a group (CH.sub.2).sub.n, n representing an integer equal to 2, 3 or 4, or alternatively a vinylene group or a methylvinylene group;R.sub.1 and R.sub.2, considered independently, represent hydrogen or a substituent occupying one of the free positions of the benzene ring and selected from the group comprising halogens, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a thiol group, a nitro group and an optionally substituted amino group;Y represents oxygen, sulfur or a group --NH--; andR.sub.3 is an amino groupApplication: agonists of the cholinergic receptors.

Abstract: The present invention relates to imidazo[1,2-b]-pyridazines having the formula: ##STR1## in which: R.sub.1 represents hydrogen, a halogen atom, a C.sub.1 -C.sub.4 alkoxy group or a C.sub.1 -C.sub.4 alkyl group occupying one of the free positions of the benzene ring; R.sub.2 represents hydrogen, a C.sub.1 -C.sub.4 alkyl group or a phenyl group; R.sub.3 denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or a phenyl group; and R.sub.4 R.sub.5 represent hydrogen or a C.sub.1 -C.sub.4 alkyl group, or R.sub.4 and R.sub.5 form, together with the nitrogen atom to which they are bonded, a 5-membered or 6-membered heterocycle optionally containing a second heteroatom. Application: drugs, especially for the treatment of cortical cholinergic deficiencies.

Abstract: The invention relates to derivatives of 2,3-dihydro 3-imino-pyridazine responding to general formula: ##STR1## in which: A represents an atom of oxygen or of sulfur;R.sub.1 represents a lower alkyl group, or an aromatic group selected from:the phenyl group;the phenyl groups mono- or poly-substituted by a halogen group, a lower alkyl group, a lower alkoxy group, a nitro group, a hydroxy or methylenedioxy group;the naphthyl group;the furyl group;the thienyl group or the pyridyl group;R.sub.2 and R.sub.3 each designate independently hydrogen or a lower alkyl group; a phenyl group, or R.sub.2 and R.sub.3, taken together, constitute, with the 2 atoms of the pyridazinic cycle to which they are bonded, a benzene ring, and their pharmaceutically acceptable salts. Application: antidepressants or psychotonics.

Abstract: The present invention relates to derivatives of pyridazine of formula: ##STR1## in which R.sub.1 is alkyl or a phenyl group and R.sub.2 is H or R.sub.1 and R.sub.2 form, with the carbon atoms to which they are attached, a benzene cycle, R.sub.3 is H or phenyl and R.sub.4 is ##STR2## in which R.sub.5 is H or CH.sub.3 and R.sub.6 is H, OH, OR or OCOR; it also relates to a process for preparing the products of formula (I) and to the drugs containing at least one of said products.

Abstract: The present invention relates to derivatives of 4-methyl 6-phenyl pyridazine of formula: ##STR1## in which R is OH or H, R.sub.1 is H or ##STR2## n being 0 or 1, X being H, Y being H or alkyl or X and Y forms an ethylene or oxoethylene group;it also relates to a process for preparing the products of formula (I) and to drugs containing at least one product of formula (I).

Abstract: The invention relates to thiadiazole derivatives corresponding to the formula: ##STR1## in which R represents: a linear or branched alkyl group having from 1 to 5 carbon atoms;a cycloalkyl group having 5 or 6 carbon atoms;a phenyl group optionally substituted by 1 or 2 halogen atoms, preferably chlorine, by 1 or 2 lower alkyl or lower alkoxy groups, by 1 or 2 hydroxyl groups or by a nitro or trifluoromethyl group;a biphenylyl group; oran alpha-naphthyl group;and the pharmaceutically acceptable salts of the said derivatives. It also relates to a process for the preparation of the said derivatives and the pharmaceutical compositions in which they are present. The said derivatives act on the central nervous system.

Abstract: The present invention relates to derivatives of 4-methyl 6-phenyl pyridazine of formula: ##STR1## in which R is OH or H, R.sub.1 is H or ##STR2## n being 0 or 1, X being H, Y being H or alkyl or X and Y forms an ethylene or oxoethylene group;it also relates to a process for preparing the products of formula (I) and to drugs containing at least one product of formula (I).

Abstract: The present invention relates to derivatives of 4-methyl 6-phenyl pyridazine of formula: ##STR1## in which R is OH or H,R.sub.1 is ##STR2## n being 0 or 1, X and Y forms an ethylene or oxoethylene group;it also relates to a process for preparing the products of formula (I) and to drugs containing at least one product of formula (I).

Abstract: The present invention relates to amino derivatives of pyridazine of general formula: ##STR1## in which one of the substituents R.sub.1, R.sub.2 or R.sub.3 represents a phenyl or hydroxyphenyl group, while the other two represent hydrogen or an alkyl group with C.sub.1 -C.sub.4 ;A represents a linear or branched alkylene group having 2 to 5 carbon atoms;X represents hydrogen or an alkyl group with C.sub.1 -C.sub.4, as well as the salts of said derivatives with the pharmaceutically acceptable acids, and also relates to a process for preparing the products of formula (I) and to drugs containing a product of formula (I).