Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: A medical instrument includes a proximal handle (3), for controlling a distal tool, including two grip pieces (4, 5) pivotable relative to one another, subjected to spring force and coupled in movement via a path guide with a path component (7). The path component includes a guide path (11), and a guide body (14) on a guide component (8). The guide body engages into the guide path. The components (7, 8) are arranged on one of the grip pieces and are subjected to a spring force, transversely to a pivoting plane of the grip pieces. One of the components (8) is pivotably arranged on a grip piece. Functionally independent of the guide body (14) and guide path (11), a latching body (12) is received by a latching receiver (16) on the components (7, 8) for a latching function, blocking pivoting movement of the grip pieces.

Abstract: The medical instrument comprises a proximal handle (3) for controlling a distal tool. The handle (3) comprises two grip pieces (4, 5) which are arranged in a pivotably movable manner relative to one another, are subjected to spring force and are coupled in movement to one another via a path guide (11, 14), wherein the path guide (11, 14) comprises a path component (7) which comprises a guide path (11), and a guide body (14) on a guide component (8), said guide body engaging into the guide path (11). The components (7, 8) are arranged on one of the grip pieces (4, 5) and are subjected to spring force to one another transversely to a pivoting plane of the grip pieces (4, 5). One of the components (8) is pivotably arranged on a grip piece (4, 5). At least one latching position, in which the pivoting movement of the grip pieces (4, 5) is blocked in one direction, is formed between the components (7, 8).