Patents by Inventor Carl A. Brooks

Carl A. Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocycle RMB39 Modulators
    Publication number: 20240092770
    Abstract: Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).
    Type: Application
    Filed: August 15, 2023
    Publication date: March 21, 2024
    Inventors: Ashraf Saeed, Chris Bailey, Carl Brooks, Kevin Fales, Janet Paulsen
  • Heterocyclic compounds and related methods
    Patent number: 11919868
    Abstract: Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: March 5, 2024
    Assignee: RECURSION PHARMACEUTICALS, INC.
    Inventors: Michael James Genin, Joseph Carpenter, Carl Brooks
  • HETEROCYCLIC COMPOUNDS AND RELATED METHODS
    Publication number: 20220380323
    Abstract: The present disclosure describes compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof, wherein all of the variables are as defined herein. This disclosure also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.
    Type: Application
    Filed: March 1, 2022
    Publication date: December 1, 2022
    Inventors: Michael James Genin, Joseph Carpenter, Carl Brooks
  • TRPV4 antagonists
    Patent number: 11260049
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 1, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
    Inventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Peng Li, Jay M. Matthews, John Jeffrey McAtee, Joseph E. Pero, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm
  • TRPV4 antagonists
    Patent number: 11229623
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: January 25, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
    Inventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Guosen Ye, Linda S. Barton, Brian W. Budzik, Jay M. Matthews, John Jeffrey McAtee, Jaclyn R. Patterson, Joseph E. Pero, Robert Sanchez, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm, James V. Thomas
  • TRPV4 ANTAGONISTS
    Publication number: 20210299113
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Application
    Filed: September 20, 2017
    Publication date: September 30, 2021
    Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Peng LI, Jay M. MATTHEWS, John Jeffrey McATEE, Joseph E. PERO, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM
  • NRF2 activators
    Patent number: 11028099
    Abstract: The present invention relates to a compound which is (R)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydropyrido[2,3-f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)propanoic acid (I), or a pharmaceutically acceptable salt thereof, in particular, the meglumine salt thereof, a pharmaceutical composition containing the compound and its use as an NRF2 activator.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 8, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Carl A. Brooks, Jay M. Matthews
  • TRPV4 antagonist
    Patent number: 10968209
    Abstract: The present invention relates to a novel compound useful as a TRPV4 antagonist, specifically the compound 1-(((5S,7R)-3-(5-cyclopropylpyrazin-2-yl)-7-hydroxy-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compound.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: April 6, 2021
    Inventors: Patrick Stoy, Carl A. Brooks, Guosen Ye
  • TRPV4 ANTAGONIST
    Publication number: 20200308160
    Abstract: The present invention relates to a novel compound useful as a TRPV4 antagonist, specifically the compound 1-(((5S,7R)-3-(5-cyclopropylpyrazin-2-yl)-7-hydroxy-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compound.
    Type: Application
    Filed: May 18, 2017
    Publication date: October 1, 2020
    Inventors: Patrick STOY, Carl A. BROOKS, Guosen YE
  • TRPV4 ANTAGONISTS
    Publication number: 20200261411
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 20, 2020
    Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Guosen YE, Linda S. BARTON, Brian W. BUDZIK, Jay M. MATTHEWS, John Jeffrey McATEE, Jaclyn R. PATTERSON, Joseph E. PERO, Robert SANCHEZ, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM, James V. THOMAS
  • TRPV4 antagonists
    Patent number: 10590077
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 17, 2020
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Edward J. Brnardic, Carl A. Brooks, Brian W. Budzik, Brian Griffin Lawhorn, Jay M. Matthews, John Jeffrey McAtee, Joseph E. Pero, David J. Behm
  • TRPV4 antagonists
    Patent number: 10588891
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 17, 2020
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Guosen Ye, Linda S. Barton, Brian W. Budzik, Jay M. Matthews, John Jeffrey McAtee, Jaclyn R. Patterson, Joseph E. Pero, Robert Sanchez, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm, James V. Thomas
  • NRF2 ACTIVATORS
    Publication number: 20200031846
    Abstract: The present invention relates to a compound which is (R)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydropyrido[2,3-f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)propanoic acid (I), or a pharmaceutically acceptable salt thereof, in particular, the meglumine salt thereof, a pharmaceutical composition containing the compound and its use as an NRF2 activator.
    Type: Application
    Filed: December 11, 2017
    Publication date: January 30, 2020
    Inventors: Carl A. BROOKS, Jay M. MATTHEWS
  • TRPV4 ANTAGONISTS
    Publication number: 20190216774
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Application
    Filed: September 20, 2017
    Publication date: July 18, 2019
    Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Guosen YE, Lisa S. BARTON, Brian W. BUDZIK, Jay M. MATTHEWS, John Jeffrey McATEE, Jacyln R. PATTERSON, Joseph E. PERO, Robert SANCHEZ, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM, James V. THOMAS
  • TRPV4 ANTAGONISTS
    Publication number: 20190202784
    Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Application
    Filed: September 20, 2017
    Publication date: July 4, 2019
    Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian W. BUDZIK, Brian Griffin LAWHORN, Jay M. MATTHEWS, John Jeffrey McATEE, Joseh E. PERO, David J. BEHM
  • TRPV4 antagonists
    Patent number: 9487507
    Abstract: The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: November 8, 2016
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Carl Brooks, Mui Cheung, Hilary Schenck Eidam, Krista B. Goodman, Marlys Hammond, Mark A. Hilfiker, Jaclyn R. Patterson, Patrick Stoy, Guosen Ye
  • Layered user interface
    Patent number: 9454619
    Abstract: A user interface for a device comprises a plurality of layers. The content for the user interface is associated with one of the plurality of layers.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 27, 2016
    Assignee: QUALCOMM Incorporated
    Inventors: Stefan Geoffrey Butlin, Nicholas Holder Clarey, Nicholas Carl Brook
  • Pipe compression clamp
    Patent number: 9206936
    Abstract: Disclosed herein is a high compression pipe clamp which in one embodiment has an inner housing and an outer housing. The hollow rigid inner housing may have a first end, an outer diameter, and a first strap bracket. The hollow rigid outer housing may have a first end, and inner diameter and a second strap bracket wherein the inner diameter of the outer housing is larger than the outer diameter of the inner housing to fit thereover. A tensioning device such as for example threaded rod is also disclosed, the threaded rod passing through the inner housing and outer housing and a threaded nut engaging the threads on the threaded rod.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: December 8, 2015
    Inventors: Carl Brooks, Larry Mehlenbacher
  • TRPV4 antagonists
    Patent number: 9187464
    Abstract: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: November 17, 2015
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Carl Brooks, Mui Cheung, Hilary Schenck Eidam, Krista B. Goodman, Marlys Hammond, Mark A. Hilfiker, Tram H. Hoang, Jaclyn R. Patterson, Patrick Stoy, Guosen Ye
  • Pipe Compression Clamp
    Publication number: 20150013816
    Abstract: Disclosed herein is a high compression pipe clamp which in one embodiment has an inner housing and an outer housing. The hollow rigid inner housing may have a first end, an outer diameter, and a first strap bracket. The hollow rigid outer housing may have a first end, and inner diameter and a second strap bracket wherein the inner diameter of the outer housing is larger than the outer diameter of the inner housing to fit thereover. A tensioning device such as for example threaded rod is also disclosed, the threaded rod passing through the inner housing and outer housing and a threaded nut engaging the threads on the threaded rod.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 15, 2015
    Inventors: Carl Brooks, Larry Mehlenbacher