Abstract: A device and method for treating a bone includes a bone plate including first and second portions joined to one another via a connecting portion, a rigidity of the connecting portion being less than rigidities of each of the first and second portions in combination with a first sensor mounted on the first portion measuring strain on the first portion and a second sensor mounted on the second portion measuring strain on the second portion.

Abstract: A device and method for treating a bone includes a bone plate including first and second portions joined to one another via a connecting portion, a rigidity of the connecting portion being less than rigidities of each of the first and second portions in combination with a first sensor mounted on the first portion measuring strain on the first portion and a second sensor mounted on the second portion measuring strain on the second portion.

Abstract: A linear actuator for pumping comprising a stator having an inner opening, a shaft having a plurality of permanent magnets spaced linearly in the axial direction, the shaft disposed in the stator opening and configured to reciprocate linearly in the axial direction relative to the stator, the stator comprising a first stator assembly having a plurality of pole sections spaced linearly in the axial direction and a plurality of coils disposed therebetween, a second stator assembly having a plurality of pole sections spaced linearly in the axial direction and a plurality of coils disposed therebetween, a bearing assembly positioned axially between the first stator assembly and the second stator assembly, and the bearing assembly having a width that is a function of the spacing of the plurality of pole sections of the first stator assembly and the second assembly and the spacing of the plurality of permanent magnets of the shaft.

Abstract: A method of assembling a shaft of a magnetic motor comprising the steps of providing a plurality of magnets (210), providing a plurality of pole pieces (212), stacking (S11) said magnets and pole pieces to form a subassembly (202) having an outer surface of a first diameter, providing a precipitation hardenable stainless steel sheet material, forming said stainless steel sheet material into a tube (S20), drawing said tube to form a precision tube having an inner surface of a second diameter (S21), said second diameter being greater than or equal to said first diameter, heat treating said precision tube to form a tubular sleeve of a Rockwell C hardness of at least about 40 and a magnetic permeability of at least about 100 (S22), and inserting said subassembly axially into said sleeve (S30), thereby forming a shaft for a magnetic motor.

Abstract: The present invention relates to a fully integrated sterilizable one time use disposable tissue visualization device and methods for using such devices. Preferred embodiments of the invention facilitate the visualization of an internal tissue site while causing a minimum of damage to the surrounding tissue. Further preferred embodiments may allow for the delivery of fluids and other treatment to an internal tissue site.

Abstract: The present invention relates to a fully integrated sterilizable one time use disposable tissue visualization device and methods for using such devices. Preferred embodiments of the invention facilitate the visualization of an internal tissue site while causing a minimum of damage to the surrounding tissue. Further preferred embodiments may allow for the delivery of fluids and other treatment to an internal tissue site.

Abstract: The present invention relates to a fully integrated sterilizable one time use disposable tissue visualization device and methods for using such devices. Preferred embodiments of the invention facilitate the visualization of an internal tissue site while causing a minimum of damage to the surrounding tissue. Further preferred embodiments may allow for the delivery of fluids and other treatment to an internal tissue site.

Abstract: The present invention relates to a fully integrated sterilizable one time use disposable tissue visualization device and methods for using such devices. Preferred embodiments of the invention facilitate the visualization of an internal tissue site while causing a minimum of damage to the surrounding tissue. Further preferred embodiments may allow for the delivery of fluids and other treatment to an internal tissue site.

Abstract: A deep well linear motor pump system (122) comprising a downhole linear electric motor (222) having a stator and a shaft configured to move linearly relative to the stator, a downhole pump (220) having an inlet (227), an outlet (228), and a piston coupled to the linear motor shaft, a motor driver system (318) connected with the linear motor and configured to provide drive commands to the linear motor, a surface control computer (126) connected with the motor drive system and configured to control the linear motor, a sensor system (224) communicating with the control computer and configured to sense operating parameters of the linear motor, and the sensor system comprising a synchronous serial interface encoder configured to sense position of the motor shaft and a temperature sensor configured to sense the temperature of the motor.

Abstract: A device for treating bone in a living body includes (a) comprises an implant configured for attachment to a bone; (b) a first sensor measuring a strain on a first portion of the implant, the first portion of the implant being configured to be mechanically coupled to a weakened portion of a bone when the implant is coupled to the bone in a target position in combination; and (c) a second sensor measuring strain in a non-weakened portion of the bone.

Abstract: The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.

Abstract: A tibial tray configured for use in a bi-cruciate retaining knee procedure can include a medial portion, a lateral portion, and an anterior connecting portion. The medial portion can have a medial superior bearing opposing surface, a medial inferior bone opposing surface, and a medial connecting surface. The lateral portion can have a lateral superior bearing opposing surface, a lateral inferior bone opposing surface, and a lateral connecting surface. The anterior connecting portion can connect the medial and lateral portions and cooperate with the medial and lateral portions to define a slot therebetween. The medial and lateral connecting surfaces can be formed on converging planes from respective inferior surfaces to superior surfaces of the tibial tray.

Abstract: A device and method for treating a bone includes a bone plate including first and second portions joined to one another via a connecting portion, a rigidity of the connecting portion being less than rigidities of each of the first and second portions in combination with a first sensor mounted on the first portion measuring strain on the first portion and a second sensor mounted on the second portion measuring strain on the second portion.

Abstract: A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers, depending on the origin of the inflammation. These differences can be readily accessed by analysis of the white cells obtained at a site to be analyzed, for example, in the synovial fluid of a knee. The analysis, by comparison with the analysis of white cells present in known conditions, can be used to differentiate between inflammation due to bacterial infection, arthritis or gout, for example. The examples demonstrate differential gene expression in cells present in synovial fluid biopsies from patients with confirmed bacterial infection as compared to patients with aseptic loosening or patients with inflammation due to gout.

Abstract: A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers, depending on the origin of the inflammation. These differences can be readily accessed by analysis of the white cells obtained at a site to be analyzed, for example, in the synovial fluid of a knee. The analysis, by comparison with the analysis of white cells present in known conditions, can be used to differentiate between inflammation due to bacterial infection, arthritis or gout, for example. The examples demonstrate differential gene expression in cells present in synovial fluid biopsies from patients with confirmed bacterial infection as compared to patients with aseptic loosening or patients with inflammation due to gout.

Abstract: A device for treating bone in a living body includes (a) comprises an implant configured for attachment to a bone; (b) a first sensor measuring a strain on a first portion of the implant, the first portion of the implant being configured to be mechanically coupled to a weakened portion of a bone when the implant is coupled to the bone in a target position in combination; and (c) a second sensor measuring strain in a non-weakened portion of the bone.

Abstract: A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers, depending on the origin of the inflammation. These differences can be readily accessed by analysis of the white cells obtained at a site to be analyzed, for example, in the synovial fluid of a knee. The analysis, by comparison with the analysis of white cells present in known conditions, can be used to differentiate between inflammation due to bacterial infection, arthritis or gout, for example. The examples demonstrate differential gene expression in cells present in synovial fluid biopsies from patients with confirmed bacterial infection as compared to patients with aseptic loosening or patients with inflammation due to gout.

Abstract: A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers, depending on the origin of the inflammation. These differences can be readily accessed by analysis of the white cells obtained at a site to be analyzed, for example, in the synovial fluid of a knee. The analysis, by comparison with the analysis of white cells present in known conditions, can be used to differentiate between inflammation due to bacterial infection, arthritis or gout, for example. The examples demonstrate differential gene expression in cells present in synovial fluid biopsies from patients with confirmed bacterial infection as compared to patients with aseptic loosening or patients with inflammation due to gout.

Abstract: A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers, depending on the origin of the inflammation. These differences can be readily accessed by analysis of the white cells obtained at a site to be analyzed, for example, in the synovial fluid of a knee. The analysis, by comparison with the analysis of white cells present in known conditions, can be used to differentiate between inflammation due to bacterial infection, arthritis or gout, for example. The examples demonstrate differential gene expression in cells present in synovial fluid biopsies from patients with confirmed bacterial infection as compared to patients with aseptic loosening or patients with inflammation due to gout.