Patents by Inventor Carl Deutsch

Carl Deutsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS
    Publication number: 20240058456
    Abstract: The present disclosure relates to molecules with a solubility tag, wherein the solubility tag comprises a chito-oligosaccharide, and to methods for increasing the solubility of a molecule. Moreover, the present disclosure relates to antibody-drug conjugates with solubility tag, methods and compounds for preparing such antibody-drug conjugates, methods for increasing the solubility of antibody-drug conjugates, antibody-drug conjugates prepared by such methods, as well as the use of such antibody-drug conjugates in medical treatment.
    Type: Application
    Filed: September 17, 2021
    Publication date: February 22, 2024
    Inventors: Carl Deutsch, Sven Kelly, Helene Crassier, Christoph Korpus, Joerg von Hagen, Ulrike Richter-Sander
  • ANTI-CEACAM5 ANTIBODIES AND CONJUGATES AND USES THEREOF
    Publication number: 20240010749
    Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.
    Type: Application
    Filed: August 13, 2021
    Publication date: January 11, 2024
    Applicant: Merck Patent GmbH
    Inventors: Jan ANDERL, Sabine RAAB-WESTPHAL, Stefan HECHT, Carl DEUTSCH, Min SHAN, Doreen KÖNNING, Willem N. SLOOT, Felix HART, Christian SCHRÖTER, Lars TOLEIKIS, Nir BERGER
  • COMBINATION THERAPY UTILIZING DNA ALKYLATING AGENTS AND ATR INHIBITORS
    Publication number: 20210369705
    Abstract: The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.
    Type: Application
    Filed: October 14, 2019
    Publication date: December 2, 2021
    Applicant: Merck Patent GmbH
    Inventors: Carl DEUTSCH, Birgit PIATER, Nicolas RASCHE, Heike DAHMEN, Frank ZENKE, Astrid ZIMMERMANN, Marcel RIEKER
  • Pyridopyrimidine derivatives as protein kinase inhibitors
    Patent number: 9725462
    Abstract: Compounds of the formula I in which R, R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: August 8, 2017
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Daniel Kuhn, Tatjana Ross, Carl Deutsch
  • 8-substituted 2-amino-[1,2,4] triazolo [1, 5-A] pyrazines as Syk tryrosine kinase inhibitors and GCN2 serin kinase inhibitors
    Patent number: 9120804
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: September 1, 2015
    Assignee: Merck Patent GmbH
    Inventors: Carl Deutsch, Daniel Kuhn, Tatjana Ross, Lars Burgdorf
  • PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20150218186
    Abstract: Compounds of the formula I in which R, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: July 10, 2013
    Publication date: August 6, 2015
    Applicant: Merck Patent GmbH
    Inventors: Lars Burgdorf, Daniel Kuhn, Tatjana Ross, Carl Deutsch
  • Triazolopyrazine derivatives
    Patent number: 9023851
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20150051202
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: February 14, 2013
    Publication date: February 19, 2015
    Applicant: Merck Patent GmbH
    Inventors: Kai Schiemann, Carl Deutsch, Guenter Hoelzemann, Daniel Kuhn, Ansgar Wegener, Dominique Swinnen, Horacio Comas
  • FUROPYRIDINE DERIVATIVES
    Publication number: 20150038527
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: January 22, 2013
    Publication date: February 5, 2015
    Applicant: Merck Patent GmbH
    Inventors: Lars Burgdorf, Tatjana Ross, Carl Deutsch
  • 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS
    Publication number: 20150025058
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: January 22, 2013
    Publication date: January 22, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Carl Deutsch, Daniel Kuhn, Tatjana Ross, Lars Burgdorf
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20130225568
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Carl Deutsch, Horacio Comas, Dominique Swinnen, Vincent Pomel, Pascale Gaillard, Brian Hodous