Patents by Inventor Carl E. Frasch
Carl E. Frasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9562894Abstract: Methods for detecting in a sample the presence of an antibody to a conjugate of an antigen associated with a first carrier by a first association are disclosed. The method comprises contacting a conjugate of the antigen associated with a second carrier by a second association with said sample under conditions that allow binding of the antibody to the antigen; and introducing an agent to detect the presence of the antibody bound to said antigen. The first association and the second association are covalent associations and the first association is different from the second association. Also provided are kits, multiwell plates and conjugates that are useful in the method and further uses of the method. Also provided is a method of releasing a batch of a vaccine comprising a conjugate of an antigen associated with a first carrier by a first association and antibodies useful in this method.Type: GrantFiled: December 12, 2012Date of Patent: February 7, 2017Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Francesco Berti, Carl E. Frasch
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Patent number: 9474795Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: November 2, 2015Date of Patent: October 25, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Publication number: 20160136256Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: November 2, 2015Publication date: May 19, 2016Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 9198976Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: May 5, 2014Date of Patent: December 1, 2015Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 9173931Abstract: Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: August 6, 2004Date of Patent: November 3, 2015Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, FiocruzInventors: Ellen Jessouroun, Ivna Alana Freitas Brasileiro Da Silveira, Renata Chagas Bastos, Carl E. Frasch, Che-Hung Robert Lee
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Publication number: 20140335544Abstract: Methods for detecting in a sample the presence of an antibody to a conjugate of an antigen associated with a first carrier by a first association are disclosed. The method comprises contacting a conjugate of the antigen associated with a second carrier by a second association with said sample under conditions that allow binding of the antibody to the antigen; and introducing an agent to detect the presence of the antibody bound to said antigen. The first association and the second association are covalent associations and the first association is different from the second association. Also provided are kits, multiwell plates and conjugates that are useful in the method and further uses of the method. Also provided is a method of releasing a batch of a vaccine comprising a conjugate of an antigen associated with a first carrier by a first association and antibodies useful in this method.Type: ApplicationFiled: December 12, 2012Publication date: November 13, 2014Inventors: Francesco Berti, Carl E. Frasch
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Publication number: 20140322258Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: May 5, 2014Publication date: October 30, 2014Applicant: The Government of the United States of America, as represented by the Secretary of the Department ofInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 8753649Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: May 10, 2013Date of Patent: June 17, 2014Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Publication number: 20130337004Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: May 10, 2013Publication date: December 19, 2013Applicant: The Government of the United States of America, as represented by the Secretary of the Department ofInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 8465749Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: September 23, 2011Date of Patent: June 18, 2013Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Publication number: 20120076817Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: September 23, 2011Publication date: March 29, 2012Inventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 8048432Abstract: Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: August 6, 2004Date of Patent: November 1, 2011Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch