Patents by Inventor Carl E. Nathan

Carl E. Nathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial proteins, compositions containing same and uses thereof
    Patent number: 5338724
    Abstract: The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparent molecular weights of about 3,500 daltons, about 13,000 daltons, about 18,000 daltons, about 29,000 daltons, and about 54,000 daltons. The composition of matter has respiratory burst-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided.Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: August 16, 1994
    Assignees: Cornell Research Foundation, Inc., Rockefeller University
    Inventors: Joelle E. Gabay, Carl E. Nathan