Patents by Inventor Carl Innes Webster

Carl Innes Webster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blood brain barrier transport molecules and uses thereof
    Patent number: 10184008
    Abstract: The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 22, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventors: Carl Innes Webster, Albert George Thom, Lutz U Jermutus, Jonathan P Hatcher
  • BLOOD BRAIN BARRIER TRANSPORT MOLECULES AND USES THEREOF
    Publication number: 20180057605
    Abstract: The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries.
    Type: Application
    Filed: December 18, 2015
    Publication date: March 1, 2018
    Inventors: Carl Innes WEBSTER, Albert George THOM, Lutz U JERMUTUS, Jonathan P HATCHER
  • Monomeric Polypeptides Comprising Variant FC Regions And Methods Of Use
    Publication number: 20130177555
    Abstract: Provided are monomeric polypeptides comprising variant Fc regions and methods of using them. In certain embodiments, monomeric polypeptides of the invention are fusion proteins. In certain embodiments, monomeric polypeptides of the invention are antibodies.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 11, 2013
    Applicant: MEDIMMUNE LIMITED
    Inventors: Ian Wilkinson, Carl Innes Webster, David Christopher Lowe
  • PROTEASE VARIANTS
    Publication number: 20120237496
    Abstract: The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates to polypeptides comprising protease variants derived from human neprilysin having an increased specificity and/or activity against certain substrates, in particular against amyloid beta.
    Type: Application
    Filed: June 21, 2010
    Publication date: September 20, 2012
    Inventors: Joerg Birkenfeld, Andrea Eicker, Per-Ola Freskgard, Claudia Gotzberger-Schad, Joanna Grudzinska, Ulrich Haupts, Josi Innig, Christoph Mahlert, Andreas Scheidig, Michael Strerath, Jan Tebbe, Johan Per-Wallin, Nina Wobst, Carl Innes Webster, Lutz Jermutus
  • Polypeptide Variants
    Publication number: 20100184959
    Abstract: The present invention relates to methods for selecting, obtaining or producing Fc variant polypeptides which show altered recognition for an Fc ligand (e.g., Fc?R, CIq). Additionally, the Fc variant polypeptides may have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variant polypeptides particularly for therapeutic purposes.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 22, 2010
    Applicant: MEDIMMUNE LIMITED
    Inventors: Gulin Guler-Gane, Robert George Edward Holgate, Lutz Ulrich Jochen Wilhelm Jermutus, Jacqueline Michaela Levens, John Norman Lund, Ross Anthony Stewart, Albert George Thom, Carl Innes Webster
  • Enhancer-increased gene expression in plants
    Patent number: 6323393
    Abstract: The invention provides enhancers for one or more gene promoters, which enhancers are nucleotide sequences rich in A and T bases, the total amount of A and T bases comprising more than 50% of the nucleotide sequence. Particular sequences are identified from the pea plastocyanin promoter which are active as enhancers, as is a solely A/T nucleotide sequence, and methods of carrying out the invention are described.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: November 27, 2001
    Assignee: Advanced Technologies (Cambridge) Ltd.
    Inventors: John Clinton Gray, Jagdeep Singh Sandhu, Carl Innes Webster