Abstract: This specification describes modified growth hormone having substantially diminished insulin-like and diabetogenic potencies relative to the native hormone with retention of substantially all of the anabolic potency of the native hormone. The modified growth hormone has the following structure: (a) elimination of from 1-5 to 1-19 amino acid residues from the amino terminus of the hormone; (b) cleavage of a peptide bond at any point from the carboxy moiety of residue 127 to residue 153; and (c) optionally, elimination of one or more of amino acid residues 128-152 of the hormone.

Abstract: There is herein described an invention for promoting the rate and improving the quality of wound healing by topically applying insulin-like growth factor-II to the wound.

Abstract: A class of compounds having growth hormone releasing activity is described. These compounds have the formula H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-X-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-A rg-Gly-Ala-Arg-Ala-Arg-Leu-Y in which Y is OH or NH.sub.2 and X is selected from the group consisting of Met(O), Met(S-Me), Hse, Gln, Asn, Ser, Thr, Leu, Ile, Ala, Gly, Pro, Val, Phe, Trp, Tyr, Cys, Lys, Arg, His, Glu, and Asp.