Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: An air filter element has a cylindrical filter media sleeve axially slidable along and around an inner liner from either axial end of the sleeve. First and second end caps at distally opposite axial ends of the liner and sleeve each have a central aperture, the aperture in the first end cap providing air flow therethrough in communication with the hollow interior of the liner, the aperture in the second end cap retaining a closing cover. The cylindrical filter media sleeve extends axially along the inner liner and is axially retained between the cover and the first end cap. The cover is removably mounted to the second end cap in snap-in relation and axially retains the sleeve on the inner liner.