Abstract: A device, method, and system for detecting emboli in the brain is disclosed. A transcranial Doppler photoacoustic device transmits a first energy to a region of interest at an internal site of a subject to produce an image and blood flow velocities of a region of interest by outputting an optical excitation energy to said region of interest and heating said region, causing a transient thermoelastic expansion and produce a wideband ultrasonic emission. Detectors receive the wideband ultrasonic emission and then generate an image of said region of interest from said wideband ultrasonic emission. A Doppler ultrasound signal will also be deployed to image the region of interest. Doppler presents changes in velocity to map blood flow. Additionally, a dye can be given to visualize the brain vasculature and a perfusion measurement can be made in various regions of the brain along with the transcranial Doppler and the photoacoustic screening.

Abstract: A method to detect a structure of interest includes shading a target from ambient light. A first plurality of images is acquired from the target. Background in the first plurality of images is reduced to minimize or eliminate brightness variation in the images and to generate a first plurality background-reduced images. A second plurality of images is acquired from the target. Background in the second plurality of images is reduced to generate a second plurality of background-reduced images. Noise in the second plurality of background-reduced images is reduced to generate a noise-reduced image, which is then multiplied to generate an amplified image. A structure of interest is detected in the amplified image. An imaging device that can be used to carry out the method is also included and includes an illuminator that shades the target from ambient light and scatters light.

Abstract: A method to detect a structure of interest includes shading a target from ambient light. A first plurality of images is acquired from the target. Background in the first plurality of images is reduced to minimize or eliminate brightness variation in the images and to generate a first plurality background-reduced images. A second plurality of images is acquired from the target. Background in the second plurality of images is reduced to generate a second plurality of background-reduced images. Noise in the second plurality of background-reduced images is reduced to generate a noise-reduced image, which is then multiplied to generate an amplified image. A structure of interest is detected in the amplified image. An imaging device that can be used to carry out the method is also included and includes an illuminator that shades the target from ambient light and scatters light.

Abstract: A human appendage, typically the inside of the elow, is illuminated with an infrared source, for example, at least one incandescent light bulb. A video camera for producing a video image and immediately overlying monitor for displaying the video image is utilized to look at the flesh. The camera is sensitive to infrared radiation. A video display results in which infrared absorbing or scattering contrasting portions of the flesh are highlighted, for example, hard to find veins for insertions of needles. A contrast enhancing circuit is included which discloses amplifying the video information with high contrast enhancement of the video. Adaptation of the disclosed circuit to conventional TV charge coupled device cameras and monitors is illustrated with compensation of horizontal sweep to even image background, intensity averaging line to line for vertical image uniformity and display of image contrasts on a log amplification format.