Abstract: The die casting machine comprises a mold closing actuator capable of selectively inducing a closing pressure on first and second platens for forcing them towards a closed position in which their mold portions are pressed against each other along a parting line. An injection sleeve is movable relative to the mold portions between a distal position in which the injection sleeve and the mold portions are spaced apart; and an injection position in which the injection sleeve engages the mold portions at an inlet opening when the first and second platens are in their closed position. The injection sleeve applies a transverse contact pressure when it engages the mold portions. The closing pressure is unevenly distributed on the platens so as to compensate the transverse contact pressure to have a resulting effective molding pressure on the mold portions that is substantially evenly distributed across the parting line.

Abstract: The die casting machine comprises a mold closing actuator capable of selectively inducing a closing pressure on first and second platens for forcing them towards a closed position in which their mold portions are pressed against each other along a parting line. An injection sleeve is movable relative to the mold portions between a distal position in which the injection sleeve and the mold portions are spaced apart; and an injection position in which the injection sleeve engages the mold portions at an inlet opening when the first and second platens are in their closed position. The injection sleeve applies a transverse contact pressure when it engages the mold portions. The closing pressure is unevenly distributed on the platens so as to compensate the transverse contact pressure to have a resulting effective molding pressure on the mold portions that is substantially evenly distributed across the parting line.

Abstract: The die casting machine comprises a mold closing actuator capable of selectively inducing a closing pressure on first and second platens for forcing them towards a closed position in which their mold portions are pressed against each other along a parting line. An injection sleeve is movable relative to the mold portions between a distal position in which the injection sleeve and the mold portions are spaced apart; and an injection position in which the injection sleeve engages the mold portions at an inlet opening when the first and second platens are in their closed position. The injection sleeve applies a transverse contact pressure when it engages the mold portions. The closing pressure is unevenly distributed on the platens so as to compensate the transverse contact pressure to have a resulting effective molding pressure on the mold portions that is substantially evenly distributed across the parting line.

Abstract: The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract: An injection unit for a hot-chamber die-casting machine has an injection portion with a gooseneck and a nozzle adaptor. The injector portion has a base portion at an end of the gooseneck adapted to receive a molten medium supply. A nozzle at an end of the nozzle adaptor is adapted to inject the molten medium supply in a die cavity. A channel between the base portion and nozzle is adapted to convey the molten medium supply therethrough. A piston chamber in the base portion is actuatable to draw the molten medium supply therein and to direct the molten medium supply in the channel for injection into the die cavity. An actuation portion is connected to the gooseneck to actuate the piston chamber. Heating cartridges are received in the injection portion adjacent to the channel to control temperature of the molten medium supply in the channel.

Abstract: Compounds having the formula (I), G is a novel side chain selected from C2-6alkenyl, A3-aryl, —OR18, heteroaryl, A1-cyano, A2—OR17, A1—C(?O)R18, A1—CO2R18, A1—C(?O)NR18R19, A1—OC(?O)R18, A1—NR18C(?O)R19, A1—OC(?O)NR18R19, A1—NR18CO2R19, A1—NR18SO2R17, A1—SO2R17, A1—NR20C(?O)NR18R19, and A1—SR18; or when y is 0 or when W is not NHR22, G may be A1-heterocyclo, wherein A1 is a bond, C1-6alkylene or C2-alkenylene, A2 is C1-6alkylene or C2-6alkenylene, and A3 is C2-6alkenylene; W is selected from —NR21R22, —OR23, —NR21C(?O)R24, —NR21CO2R24, amidino, guanidino, or a heteroaryl, heterocyclo or C3-7cycloalkyl as defined in the specification, and X and R1 through R24 are as defined in the specification, are effective as modulators of melanocortin-receptors, particularly MC-1R and MC-4R.

Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, in which E is X is N or CH, W is —NR16R17, —NR16C(?O)R22, —NR16CO2R22, —OR23, or a heteroaryl or heterocyclo group as defined in the specification, and R1 through R12, R16, R17, R22, R23, x, y, and z are as defined in the specification, are useful as modulaters of melanocortin receptors, particularly MC-1R and MC-4R.

Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, in which E is X is N or CH, W is —NR16R17, —NR16C(?O)R22, —NR16CO2R22, —OR23, or a heteroaryl or heterocyclo group as defined in the specification, and R1 through R12, R16, R17, R22, R23, x, y, and z are as defined in the specification, are useful as modulaters of melanocortin receptors, particularly MC-1R and MC-4R.

Abstract: A multiple-slide die-casting machine for casting pieces has a frame. A table is operatively mounted to the frame. A slide guiding mechanism is secured to the table and has slides. Each slide has a die section. The slides are actuatable in a close/open action such that the die sections mate to form a die cavity. An injection unit is mounted to the frame and is adapted to be connected to a molten medium supply. The injection unit has a nozzle and is adapted to inject molten medium from the supply into the die cavity through the nozzle for casting a piece. A relative displacement configuration is provided between the table and the injection unit such that the die sections on the table are disengageable from with the nozzle for injection of a cast product from the die cavity.

Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: A multiple-slide die-casting machine is equipped with improved mechanical structure and unique injection control system to improve the quality of molded products, to achieve flash free castings of improved surface finish. The clamping assemblies are mounted on one side of a base plate of the machine for applying clamping force to the mold sections in a preloaded state. A reinforcement ring interconnects the clamping assemblies to inhibit deflection of the base plate and the brackets which support the clamping assemblies so that an accurate parting line between the contacting surfaces of mold sections is insured.

Abstract: A multiple-slide die-casting machine is equipped with improved mechanical structure and unique injection control system to improve the quality of molded products, to achieve flash free castings of improved surface finish. The clamping assemblies are mounted on one side of a base plate of the machine for applying clamping force to the mold sections in a preloaded state. A reinforcement ring interconnects the clamping assemblies to inhibit deflection of the base plate and the brackets which support the clamping assemblies so that an accurate parting line between the contacting surfaces of mold sections is insured.

Abstract: Compounds having the formula (I), 1

Abstract: A multiple-slide die-casting machine for casting of magnesium pieces, comprising a frame. A table is operatively mounted to the frame. A slide guiding mechanism is secured to the table and has slides. Each slide has a die section at an operating end thereof. The slides are actuatable in a close/open action such that the die sections mate at a parting line therebetween to form a die cavity. An injection unit is mounted to the frame and is adapted to be connected to a molten magnesium supply means. The injection unit has a nozzle and is adapted to inject molten magnesium from the supply means into the die cavity through the nozzle for casting a piece.

Abstract: A multiple-slide die-casting machine is equipped with improved mechanical structure and unique injection control system to improve the quality of molded products, to achieve flash free castings of improved surface finish. The clamping assemblies are mounted on one side of a base plate of the machine for applying clamping force to the mold sections in a preloaded state. A reinforcement ring interconnects the clamping assemblies to inhibit deflection of the base plate and the brackets which support the clamping assemblies so that an accurate parting line between the contacting surfaces of mold sections is insured.

Abstract: A multiple-slide die-casting machine for casting of magnesium pieces, comprising a frame. A table is operatively mounted to the frame. A slide guiding mechanism is secured to the table and has slides. Each slide has a die section at an operating end thereof. The slides are actuatable in a close/open action such that the die sections mate at a parting line therebetween to form a die cavity. An injection unit is mounted to the frame and is adapted to be connected to a molten magnesium supply means. The injection unit has a nozzle and is adapted to inject molten magnesium from the supply means into the die cavity through the nozzle for casting a piece.

Abstract: The present invention provides compounds of formula I, 1

Abstract: The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.