Patents by Inventor Carl Yamashiro

Carl Yamashiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for biodosimetry with biochip using gene expression signatures
    Patent number: 9255348
    Abstract: Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: February 9, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Frederic Zenhausern, Christine Orozco, Mark Richards, Carl Yamashiro, Sally A. Amundson, Ralf Lenigk, Michael L. Bittner, Yoganand Balagurunathan
  • SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES
    Publication number: 20100144558
    Abstract: Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
    Type: Application
    Filed: August 24, 2007
    Publication date: June 10, 2010
    Inventors: Frederic Zenhausern, Christine Orozco, Mark Richards, Carl Yamashiro, Sally A. Amundson, Ralf Lenigk, Michael L. Bittner, Yoganand Balagurunathan
  • P450 single nucleotide polymorphism biochip analysis
    Patent number: 6986992
    Abstract: This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby improving the specificity and efficiency of P450 SNP detection in target samples with minimal false positive results. The invention thus describes a variety of methods to decrease self-extension of interrogation probes. In addition, this invention provides a unique collection of P450 SNP probes on one assay, primer sequences for specific amplification of each of the seven P450 genes and amplicon control probes to evaluate whether the intended p450 gene targets were amplified successfully. The invention also describes a variety of array platforms for performing the assays of the invention; for example: CodeLink™, eSensor™, multiplex arrays with cartridges etc., all described herein.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: January 17, 2006
    Assignee: Amersham Biosciences AB
    Inventors: Buena Chui, Robert Elghanian, Vineet Gupta, Krishnamurthy Jayaraman, Gretchen Kiser, Changming Li, Chang-Gong Liu, Kenneth R. Luehrsen, Abhijit Mazumder, Ramesh Ramakrishnan, Arkadiy Silbergleyt, Todd Tuggle, Carl Yamashiro, Handy Yowanto, Ekaterina Pestova, David R. Fermin, David G. Wang, Zhijie John Gu
  • P450 single nucleotide polymorphism biochip analysis
    Publication number: 20040229222
    Abstract: This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby improving the specificity and efficiency of P450 SNP detection in target samples with minimal false positive results. The invention thus describes a variety of methods to decrease self-extension of interrogation probes. In addition, this invention provides a unique collection of P450 SNP probes on one assay, primer sequences for specific amplification of each of the seven P450 genes and amplicon control probes to evaluate whether the intended p450 gene targets were amplified successfully. The invention also describes a variety of array platforms for performing the assays of the invention; for example: CodeLink™, eSensor™, multiplex arrays with cartridges etc., all described herein.
    Type: Application
    Filed: April 1, 2002
    Publication date: November 18, 2004
    Inventors: Buena Chui, Robert Elghanian, Vineet Gupta, Krishnamurthy Jayaraman, Gretchen Kiser, Changming Li, Chang-Gong Liu, Kenneth R. Luehrsen, Abhijit Mazumder, Ramesh Ramakrishnan, Arkadiy Silbergleyt, Todd Tuggle, Carl Yamashiro, Handy Yowanto, Ekaterina Pestova, David R. Fermin, David G. Wang, Zhijie John Gu