Patents by Inventor Carlos A. Valdez

Carlos A. Valdez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200086165
    Abstract: A fitness machine enabling several lunge and squat-style exercises comprises a frame that provides the basic structure of the machine. The frame includes a set of horizontal beams and a set of vertical beams creating a rectangular interior exercise space for a user to stand. A handle is included with each horizontal guide rail that slides forward and backward along the horizontal guide rail. The horizontal guide rail is movably connected between two of the vertical guide rails such that the horizontal guide rail freely slides up and down the vertical guide rails, ensuring that the horizontal guide rail maintains a parallel relationship with the floor throughout the entire range of motion during use. The handles and the horizontal guide rails significantly improve the user's balance during the exercise, eliminating unnecessary stress on the knees, hips, and lower back.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 19, 2020
    Inventors: Daniel Carlos Valdez, Ken Carter
  • Patent number: 10590498
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 17, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Brian Bennion, Tim Carpenter, Heather Ann Enright, Felice Lightstone, Mike Malfatti, Margaret Windy McNerney, Tuan H. Nguyen
  • Publication number: 20190359562
    Abstract: Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh?Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB).
    Type: Application
    Filed: February 8, 2018
    Publication date: November 28, 2019
    Inventors: Mathew Gerald LYMAN, Lawrence DUGAN, Roald N. LEIF, Bonnee RUBINFELD, Brian E. SOUZA, Carlos A. VALDEZ
  • Patent number: 10442871
    Abstract: Novel thioalkylcarboxylate-modified CDs and pharmaceutical compositions comprising these thioalkylcarboxylate-modified CDs are disclosed, as well as methods of using the disclosed thioalkylcarboxylate-modified CDs and pharmaceutical compositions thereof to neutralize or reduce undesired effects or symptoms associated with one or more fentanyl related compounds in a subject in need thereof. The use of the disclosed thioalkylcarboxylate-modified CDs to detect the presence of one or more fentanyl related compounds in a sample is also disclosed, which comprises contacting the sample with said thioalkylcarboxylate-modified CDs or a composition comprising these CDs.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: October 15, 2019
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Daniel Joseph Kennedy, Brian P. Mayer, Carlos A. Valdez
  • Publication number: 20190152920
    Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Inventors: Carlos A. Valdez, Nicholas A. Be, Michael A. Malfatti, Heather Ann Enright, Brian J. Bennion, Timothy S. Carpenter, Saphon Hok, Hio leong Lao, Tuan H. Nguyen
  • Publication number: 20190040018
    Abstract: Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals.
    Type: Application
    Filed: September 19, 2018
    Publication date: February 7, 2019
    Inventors: Carlos A. Valdez, Edmond Y. Lau, Brian P. Mayer
  • Patent number: 10189864
    Abstract: A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: January 29, 2019
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos Valdez, Edmond Y. Lau, Brian P. Mayer
  • Publication number: 20180371110
    Abstract: Novel thioalkylcarboxylate-modified CDs and pharmaceutical compositions comprising these thioalkylcarboxylate-modified CDs are disclosed, as well as methods of using the disclosed thioalkylcarboxylate-modified CDs and pharmaceutical compositions thereof to neutralize or reduce undesired effects or symptoms associated with one or more fentanyl related compounds in a subject in need thereof. The use of the disclosed thioalkylcarboxylate-modified CDs to detect the presence of one or more fentanyl related compounds in a sample is also disclosed, which comprises contacting the sample with said thioalkylcarboxylate-modified CDs or a composition comprising these CDs.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 27, 2018
    Inventors: Daniel Joseph KENNEDY, Brian P. MAYER, Carlos A. VALDEZ
  • Patent number: 10137324
    Abstract: In one embodiment, a method includes contacting a phosphotriester and a halogen salt in a polar solvent. In another embodiment, a method for dealkylating tributylphosphate includes contacting tributylphosphate and a halogen salt in a polar solvent.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: November 27, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Daniel J. Kennedy, Roald N. Leif, Brian P. Mayer, Carlos A. Valdez
  • Patent number: 10112912
    Abstract: Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: October 30, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos Valdez, Edmond Y. Lau, Brian P. Mayer
  • Patent number: 10088491
    Abstract: Provided herein are methods for sequestering an alkyne-presenting molecule in a sample and related sequestration reagents, compositions, methods and systems.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 2, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Alexander K. Vu
  • Patent number: 10082514
    Abstract: Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: September 25, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Audrey M. Williams
  • Publication number: 20170368396
    Abstract: In one embodiment, a method includes contacting a phosphotriester and a halogen salt in a polar solvent. In another embodiment, a method for dealkylating tributylphosphate includes contacting tributylphosphate and a halogen salt in a polar solvent.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 28, 2017
    Inventors: Daniel Joseph Kennedy, Roald Leif, Brian P. Mayer, Carlos Valdez
  • Publication number: 20170335415
    Abstract: Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 23, 2017
    Inventors: Carlos A. VALDEZ, Nicholas A. BE, Brian BENNION, Tim CARPENTER, Heather Ann ENRIGHT, Felice LIGHTSTONE, Mike MALFATTI, Margaret Windy MCNERNEY, Tuan H. NGUYEN
  • Patent number: 9791463
    Abstract: Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. The methods include contacting a detection reagent with the sample for a time and under a condition to allow binding of the detection reagent to the one or more alkyne-presenting molecules possibly present in the matrix to the detection reagent. The detection reagent includes an organic label moiety presenting an azide group. The binding of the azide group to the alkyne-presenting molecules results in emission of a signal from the organic label moiety.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 17, 2017
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Alexander K. Vu
  • Publication number: 20170253568
    Abstract: Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 7, 2017
    Inventors: Carlos Valdez, Edmond Y. Lau, Brian P. Mayer
  • Publication number: 20170240569
    Abstract: A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 24, 2017
    Inventors: Carlos Valdez, Edmond Y. Lau, Brian P. Mayer
  • Patent number: 9453028
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: September 27, 2016
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Haoran Zhao, Rao Kolluri, Carlos Valdez, Kin Tso, Rajinder Singh, John Ramphal
  • Patent number: 9259725
    Abstract: According to one embodiment, a catalyst includes a metal ion, and an acyclic ligand having at least one aza-containing moiety, where the ligand is complexed to the metal ion.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: February 16, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: William C. Floyd, III, Carlos A. Valdez, Roger Aines, Sarah Baker, Joe H. Satcher, Jr.
  • Publication number: 20150376203
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 31, 2015
    Inventors: Haoran Zhao, Rao Kolluri, Carlos Valdez, Kin Tso, Rajinder Singh, John Ramphal