Abstract: The present invention provides a computer device and a computer-implemented method to quantify the extent of functional coronary artery disease. In addition, the invention provides a computer device for determining the functional pattern of coronary disease in a mammal. It is shown that a mismatch in the extent of CAD between anatomical and physiological evaluations is predictable for an improvement in epicardial conductance with percutaneous revascularization. More particularly the invention provides methods to select a mammal suffering from coronary disease to benefit from a percutaneous coronary intervention.

Abstract: The present invention provides means and methods for the assessment of coronary vessels, in particular to determine the patterns of blockage or restriction to the blood flow through a coronary vessel. More particularly, the present invention relates to a generalized approach to synchronize angiographic projection angles in real time with external 3-dimensional coronary CT angiographic images. Accordingly, a system is provided to project two-dimensional angiographic images side by side with three-dimensional coronary CT images.

Abstract: Method and systems are described that create a 3D reconstruction of a vessel of interest that represents a subset of a coronary tree that includes a lesion; calculate at least one of pressure parameters or anatomical parameters based at least in part on a portion of the 3D reconstruction that includes the lesion; calculate a wall shear stress (WSS) descriptor, based on the 3D reconstruction, for a segment of a surface of the vessel that includes the lesion, wherein the WSS descriptor includes information regarding an amount of variation in contraction or expansion applied at surface elements within the segment during at least a portion of a cardiac cycle; and calculate a myocardial infarction (MI) index based on the WSS descriptor and the at least one of the pressure or anatomical parameters, the MI index representing a likelihood that the lesion will result in an MI.