Abstract: A look-up table for use in determining an energy parameter for photodisrupting ocular tissue with a laser is generated by determining a plurality of individual spot size distributions, wherein each of the plurality of individual spot size distributions is based on a different set of simulated data and includes an expected spot size of a laser focus at each of a plurality of locations within a modeled target volume of ocular tissue. The plurality of individual spot size distributions are combined to obtain a final spot size distribution that includes a final expected spot size of the laser focus at the plurality of locations of the focus within the modeled target volume of ocular tissue. An energy value is assigned to the plurality of locations of the focus within the modeled target volume of ocular tissue based on the final expected spot size at that location.

Abstract: A method of imaging and treating ocular tissue of an eye having a cornea, an iris, an anterior chamber, an irido-corneal angle, and a direction of view includes establishing a common optical path through the cornea and the anterior chamber into the irido-corneal angle for each of an optical coherence tomography (OCT) beam and a laser beam, where the common optical path is offset from an optical axis within the direction of view. The method also includes obtaining a circumferential OCT image of the irido-corneal angle, obtaining an azimuthal OCT image of the irido-corneal angle, and determining a treatment pattern for a volume of ocular tissue of the irido-corneal angle based on the circumferential OCT image and the azimuthal OCT image. The method further includes delivering optical energy through the laser beam in accordance with the treatment pattern.

Abstract: A device for visualizing an irido-corneal angle of an eye through a window of a patient interface configured to be placed on the eye includes and optics structure and at least one imaging apparatus. The optics structure is configured to engage with the patient interface to provide a line of sight through the window in the direction of the irido-corneal angle, and to subsequently disengage from the patient interface. The imaging apparatus is associated with the optics structure and aligned with the line of sight to enable capturing an image of the eye including the irido-corneal angle.

Abstract: A system accesses a target volume of ocular tissue and treats the target volume with a laser based on the pigmentation of the tissue. A visual observation apparatus captures a color image of the target volume through an optics assembly. A control system processes the captured image and determines an energy parameter based on pigmentation of the target volume of ocular tissue. A laser source outputs a laser beam, and one or more components focus, scan, and direct the laser beam through the target volume by way of the optical assembly. The control system controls the one or more components based on a treatment pattern to place a focus of the laser beam at an initial location within the target volume of ocular tissue, and controls the laser source to apply photodisruptive energy at the initial location based on the energy parameter determined by the control system.

Abstract: A metering pump for providing relatively small, precise volumes of fluid is provided. The pump piston and/or the interior of the cylinder has a surface finish exhibiting a roughness average within selected limits and a vapor deposited polymer such as polytetrafluoroethylene. A drive mechanism is provided for simultaneously rotating and reciprocating the piston within a cylindrical chamber. Fluid is thereby drawn into the chamber and expelled. The pump can be employed in a dialysate circuit or other fluidic circuits containing crystal or other residue-forming fluids, obviating the need for pump wash ports.