Abstract: Disclosed is a portable magnifier camera that can be selectively positioned into a variety of configurations. At least four distinct viewing configurations are provided: a reading mode wherein the camera rests flatly upon the viewed object; a writing mode wherein the camera rests at an angle upon the viewed object; a hand-held mode wherein the user holds the camera relative to a distant object; and an inspection mode wherein the user holds the viewed object relative to the camera. These configurations enable a user to effectively view objects of differing size and at varying distances.

Abstract: The present invention discloses an electromechanical tactile cell assembly comprising a plurality of piezoelectric element reeds, each one of the piezoelectric element reeds being bendable at an elongated end portion when a voltage is applied to the reed, a plurality of conductive fulcrum pins secured to a printed circuit board, and a plurality of multiple element conductive supports secured to a printed circuit board, each multiple element conductive support, in combination with the plurality of conductive fulcrum pins, adapted to secure a plurality of piezoelectric reeds, corresponding to the plurality of conductive fulcrum pins, to the printed circuit board. The electromechanical tactile cell is adaptable for use with a Braille display.

Abstract: The present invention discloses a Braille display assembly including a plurality of individual Braille cells positioned in a substantially rectangular housing having a backplane forming a portion of a top wall of the rectangular housing, the backplane adapted to receive a plurality of Braille cells, the rectangular housing selected to maintain each of the plurality of individual Braille cells in a predetermined position, independent of the positioning of the other cells. A plurality of sets of tactile pin holes are formed in the top wall of the rectangular housing, each tactile pin being adapted to slideably receive a tactile pin and a plurality of control buttons are positioned adjacent the top wall and in circuit communication with the backplane. A cell cap, providing a common tactile surface for the plurality of Braille cells, is included, the cell cap being releasably engaged to the top wall of the rectangular housing.

Abstract: The present invention discloses an electromechanical tactile cell assembly comprising a plurality of piezoelectric element reeds, each one of the piezoelectric element reeds being bendable at an elongated end portion when a voltage is applied to the reed, a plurality of conductive fulcrum pins secured to a printed circuit board, and a plurality of multiple element conductive supports secured to a printed circuit board, each multiple element conductive support, in combination with the plurality of conductive fulcrum pins, adapted to secure a plurality of piezoelectric reeds, corresponding to the plurality of conductive fulcrum pins, to the printed circuit board. The electromechanical tactile cell is adaptable for use with a Braille display.

Abstract: An electromechanical Braille cell assembly includes a plurality of parallel bimorph reeds. A first plurality of bimorph reeds is mounted to a first side of a printed circuit board by a first plurality of clips and a second plurality of bimorph reeds is mounted to a second side of the printed circuit board by a second plurality of clips. A frame has a top wall, a bottom wall, a first side wall in the form of an angle wall and a second side wall in the form of a flat wall. Pinholes are formed in the angle wall to accommodate Braille pins and the flat wall is slotted to accommodate a plurality of printed circuit boards. A monolithic cap covers all of the Braille pins. Pinholes formed in the cap receive the respective tips of the Braille cells when actuated bimorph reeds cause displacement of the Braille pins.

Abstract: A box-like illuminator includes a top wall having a flat sheet of clear material through which an illuminated image is viewed. A bottom wall of the illuminator is also formed of a flat sheet of clear material and is positioned atop the object to be illuminated. Light from an LED is directed in a first, downward direction onto a deflection wall where it is deflected into a substantially horizontal plane, substantially orthogonal to the first direction. The deflected light impinges upon a horizontally-disposed diffuser that bends the light about ninety degrees so that it travels though the diffuser a first time in a first direction and illuminates the object atop which the illuminator is positioned. The light is then reflected by the object, travels upwardly through the diffuser a second time in a direction opposite to the first direction, and is viewed by the user through the clear material.

Abstract: A magnifier for use by people with low vision includes a large LCD display upon which an enlarged image appears. Light from an LED is directed in a first direction onto a deflection wall where it is deflected into a direction substantially orthogonal to the first direction. The deflected light impinges upon a diffuser that bends it so that it illuminates an object upon which the magnifier is placed. The light is then reflected by the object, through the diffuser, and onto a mirror positioned at an angle relative to the object. The mirror directs the light onto a camera lens and the lens focuses the light onto a sensor that drives the LCD display so that the image appears on the LCD screen. The camera is slideably mounted so the user can make the image larger or smaller by sliding the camera toward or away from the mirror, respectively.

Abstract: A method for performing screening of one or more cell groups of interest obscured by a cell population such as one or more subsets of interest of a WBC population utilizing at least one light sensing parameter. The cell group of interest is enumerated by utilizing microspheres having monoclonal antibodies bound thereto to modify the sensed characteristics of specified cells to differentiate the cell group of interest from the obscuring cell population.

Abstract: A method and apparatus for differentiating and enumerating the five major sub-populations of leukocytes in a blood sample (i.e., lymphocytes, monocytes, eosinophils, neutrophils and basophils) uses multiangle light scatter and DC (Coulter) volume measurements. Light scattering characteristics of the leukocytes are determined within five different angular ranges, all being lower than 40 degrees. The invention is particularly useful in differentiating and enumerating the basophil sub-population which has heretofore required more complex apparatus and/or chemical processing.

Abstract: A blood analyzing instrument includes a single transducer for simultaneously measuring the DC volume, RF conductivity, light scattering and fluorescence characteristics of blood cells passing through a cell-interrogation zone. Preferably, the transducer includes an electro-optical flow cell which defines a cell-interrogation zone having a square transverse cross-section measuring approximately 50×50 microns, and having a length, measured in the direction of cell flow, of approximately 65 microns.

Abstract: A method and apparatus for performing screening of obscured or partially obscured cells to enumerate one or more cell population subsets. For example, a whole blood sample or portion thereof is screened to provide the desired analysis of one or more white blood cell population subsets in the sample. A white blood cell population including the obscured subset of interest is first counted, along with a standard population. The standard population can be one of the total number of white blood cell populations, a second white blood cell population which does not obscure the shifted or non-shifted sensed characteristic of the subset of interest, an artificial population formed by microspheres which also do not obscure the shifted or non-shifted sensed characteristic of the subset of interest or a white blood cell population into which the sensed characteristic of the subset will be wholly or partially shifted.

Abstract: An electronic device (50) includes an infrared transceiver (510) having adjustable infrared signal intensity capability. The electronic device (50) commences to establish communications with a secondary device (420 and/or 430) at a first power level, if the communication link is not established, the electronic device (50) increases the IR power level and tries again to establish communications. In an alternate embodiment, the electronic device (50) includes a power level table which keeps the power level which has been established for each secondary device (420, 430) using the method described above. The electronic device (50) before communicating with each of the secondary devices determines the proper power level to use depending on the secondary device (420, 430) it wants to communicate with.

Abstract: A stable colloidal particle comprises a colloidal-sized core substrate having amine-reactive functional groups thereon with an aminodextran coating over its peripheral surface and a layer of colloidal-sized metallic solid overlaying the aminodextran coating. A linker comprising aminotrithiolate attached to the metallic solid has a free amino group to which a protein is attached by covalent bonding to the free amino group. Such novel particles are useful in flow cytometry, particularly useful in the simultaneous analyses of subpopulations of leukocytes. Methods of preparation of such particles, as well as methods of use are provided. These conjugates enable the simultaneous analyses of at least two different mutually exclusive subsets of white blood cells, based on the binding affinity of the conjugated protein.

Abstract: The present invention provides an apparatus and method to determine individual red blood cell shape within a flow cytometric aperture. Cell shape is determined by measuring the asymmetry of a light scatter pattern produced by laser illumination of the cell within the aperture by light scatter detectors which collect light from specific angular regions of light scatter, and analyzing the asymmetry of the light scatter patters to determine the individual red blood cell shape. Embodiments of the invention further provide for the determination of red blood cell shape by measuring the asymmetry of a light scatter pattern and measuring electrical resistance of the red blood cell.

Abstract: A reticulocyte analyzing method and apparatus in which a biological sample stream of ghosted red cells is passed into and through a point focused beam of light, such as laser light. A light detector structure is positioned with respect to the axis of the light beam to provide a light output pulse indicative of the passage of each cell. Electrically conductive contacts within the fluid stream can provide additional electrical pulse outputs of each cell. A staining reagent can be utilized with a ghosting reagent to further differentiate the reticulocytes. The light and the light and electronic produced output pulses or signals can be combined to define and quantify reticulocytes as distinct from other known cell types.

Abstract: A reticulocyte analyzing method and apparatus in which a biological sample stream of ghosted red cells is passed into and through a point focused beam of light, such as laser light. A light detector structure is positioned with respect to the axis of the light beam to provide a light output pulse indicative of the passage of each cell. Electrically conductive contacts within the fluid stream can provide additional electrical pulse outputs of each cell. A staining reagent can be utilized with a ghosting reagent to further differentiate the reticulocytes. The light and the light and electronic produced output pulses or signals can be combined to define and quantify reticulocytes as distinct from other known cell types.

Abstract: A method and apparatus for automatically and rapidly, retrieving counting and/or analyzing at least one selected population of cells or formed bodies, such as a white blood cell population and at least one subset thereof of a whole blood sample or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. A multipart blood cell analysis is obtained with a single sensing parameter by depleting at least one WBC subset population. The percentage of a desired WBC population subset or the overlapping of WBC subset populations also can be obtained by subtracting one or more obscuring WBC subset populations.

Abstract: A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected population of cells or formed bodies, such as a white blood cell population and at least one subset thereof of a whole blood sample or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed in one or more steps to obtain the desired white blood cell population and subset analysis. The biological sample can be a whole blood sample and the reactant can include or be a lyse or a monoclonal antibody bound to microspheres, which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto.

Abstract: Disclosed is a flow through particle analyzing cell differentiating apparatus for optical and electronic measurements on a stream of particles in which a hydrodynamically focoussed stream is passed into and through a point focussed beam of radiated energy whereby the beam is scattered by the stream to impinge upon light responsive signal operating members disposed adjacent the cell at angular positions relative to the beam axis of from about 10.degree. to 70.degree..

Abstract: A circuit, which is useful to provide data needed to measure the electrical opacity of a particle, for instance a blood cell, passing through a Coulter type transducer, includes a current source for providing a conventional d.c. current through the sensing aperture of the transducer, as well as an oscillator for providing a high frequency current through the aperture. The oscillator includes an active device and a resonant circuit, and the aperture is coupled in parallel with the resonant circuit of the oscillator. The oscillator can be any type of oscillator, such as a Hartley oscillator. As a particle passes through the aperture, the resistance of the aperture increases, which in turn, increases the Q of the oscillator circuit, whereby the oscillator output signal is amplitude modulated in accordance with the increased Q. This amplitude modulated signal can be detected to provide a value based on the high frequency reactance of the particle being detected. The change in d.c.