Patents by Inventor Carly G. K. ZIEGLER

Carly G. K. ZIEGLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING AND MODULATING CO-OCCURANT CELLULAR PHENOTYPES
    Publication number: 20230183786
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: July 19, 2022
    Publication date: June 15, 2023
    Inventors: Alexander K. Shalek, Alexander S. Genshaft, Carly G.K. Ziegler, Jeffrey F. Van Humbeck
  • Methods for identifying and modulating co-occurant cellular phenotypes
    Patent number: 11427861
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: August 30, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Alexander K. Shalek, Alexander S. Genshaft, Carly G. K. Ziegler, Jeffrey F. Van Humbeck
  • METHODS AND COMPOSITION FOR MODULATING IMMUNE RESPONSE AND IMMUNE HOMEOSTASIS
    Publication number: 20210118522
    Abstract: The present invention discloses novel methods, uses thereof, and compositions for modulating immune responses and homeostasis in a lymph node (LN). Moreover, structural and molecular characteristics of LN-innervating sensory neurons are provided. The present invention also discloses the target cells for LN-innervating sensory neurons in LN and molecular profiles of these target cells. These molecular characteristics provide therapeutic targets for modulating immune response and immune homeostasis in LN in an animal or a human.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Inventors: Carly G.K. Ziegler, Siyi Huang, Ulrich H. von Andrian, Alexander K. Shalek
  • METHODS FOR IDENTIFYING AND MODULATING CO-OCCURANT CELLULAR PHENOTYPES
    Publication number: 20200115753
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: March 19, 2018
    Publication date: April 16, 2020
    Inventors: Alexander K. Shalek, Alexander S. Genshaft, Carly G.K. Ziegler, Jeffrey F. Van Humbeck, Ryan Philip King
  • METHODS FOR IDENTIFYING AND MODULATING CO-OCCURANT CELLULAR PHENOTYPES
    Publication number: 20190093154
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: March 17, 2017
    Publication date: March 28, 2019
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Alexander K. SHALEK, Alexander S. GENSHAFT, Carly G. K. ZIEGLER, Jeffrey F. VAN HUMBECK