Patents by Inventor Carmela Napolitano

Carmela Napolitano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Broad spectrum antivirulence, anti-persistence compounds
    Patent number: 11731946
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 22, 2023
    Assignees: The General Hospital Corporation, Aptuit (Verona) SRL, An Evotec Company
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
  • Antimicrobial Compounds and Methods
    Publication number: 20230159491
    Abstract: The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 25, 2023
    Inventors: Ryan E. Looper, Paul Sebahar, Hariprasada R. Kanna Reddy, Travis J. Haussener, Charles A. Testa, Benlsaac C. Tresco, Seth Grant, Carmela Napolitano, Fabio Maria Sabbatini
  • Antimicrobial Compounds and Methods
    Publication number: 20230072397
    Abstract: The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 9, 2023
    Inventors: Ryan E. Looper, Paul Sebahar, Hariprasada R. Kanna Reddy, Travis J. Haussener, Charles A. Testa, Benlsaac C. Tresco, Seth Grant, Carmela Napolitano, Fabio Maria Sabbatini
  • COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS
    Publication number: 20220396581
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: April 12, 2021
    Publication date: December 15, 2022
    Applicant: Janssen BioPharma, Inc.
    Inventors: Guangyi WANG, Leonid BEIGELMAN, Anh TRUONG, Carmela NAPOLITANO, Daniele ANDREOTTI, Haiying HE
  • PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS
    Publication number: 20220389000
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
    Type: Application
    Filed: September 18, 2020
    Publication date: December 8, 2022
    Applicant: SYNGENTA CROP PROTECTION AG
    Inventors: Ottmar Franz HUETER, Damien BONVALOT, Farhan BOU HAMDAN, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, Elke Maria HILLESHEIM, Olivier JACOB, Pierre Joseph Marcel JUNG, Amandine KOLLETH KRIEGER, Thomas PITTERNA, Martin POULIOT, Sebastian RENDLER, Peter RENOLD, Christopher Charles SCARBOROUGH, Vikas SIKERVAR, Carmela NAPOLITANO
  • ANTIVIRAL COMPOUNDS
    Publication number: 20220363640
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: March 22, 2021
    Publication date: November 17, 2022
    Applicant: Janssen BioPharma, Inc.
    Inventors: Guangyi WANG, Leonid BEIGELMAN, Anh TRUONG, Carmela NAPOLITANO, Daniele ANDREOTTI, Haiying HE, Karin Ann STEIN
  • Antiviral compounds
    Patent number: 11021444
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: June 1, 2021
    Assignee: Janssen BioPharma, Inc.
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He, Karin Ann Stein
  • Compounds for the treatment of paramyxovirus viral infections
    Patent number: 11014935
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 25, 2021
    Assignee: Janssen BioPharma, Inc.
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He
  • BROAD SPECTRUM ANTIVIRULENCE, ANTI-PERSISTENCE COMPOUNDS
    Publication number: 20210130306
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Application
    Filed: October 19, 2018
    Publication date: May 6, 2021
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
  • Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1)
    Patent number: 10709692
    Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: July 14, 2020
    Assignee: Denali Therapeutics Inc.
    Inventors: Giorgio Bonanomi, Anthony A. Estrada, Jianwen A. Feng, Brian Fox, Colin Philip Leslie, Joseph P. Lyssikatos, Carmela Napolitano, Alfonso Pozzan, Anantha Sudhakar, Zachary K. Sweeney, Federica Tonelli, Javier de Vicente Fidalgo
  • ANTIVIRAL COMPOUNDS
    Publication number: 20190263754
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: October 19, 2018
    Publication date: August 29, 2019
    Applicant: Alios BioPharma, Inc.
    Inventors: Guangyi WANG, Leonid BEIGELMAN, Anh TRUONG, Carmela NAPOLITANO, Daniele ANDREOTTI, Haiying HE, Karin Ann STEIN
  • ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK1)
    Publication number: 20180353480
    Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Inventors: Giorgio Bonanomi, Anthony A. Estrada, Jianwen A. Feng, Brian Fox, Colin Philip Leslie, Joseph P. Lyssikatos, Carmela Napolitano, Alfonso Pozzan, Anantha Sudhakar, Zachary K. Sweeney, Federica Tonelli, Javier de Vicente Fidalgo
  • ANTIVIRAL COMPOUNDS
    Publication number: 20180065932
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: August 16, 2017
    Publication date: March 8, 2018
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He, Karin Ann Stein
  • COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS
    Publication number: 20170283429
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: June 20, 2017
    Publication date: October 5, 2017
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He
  • Compounds for the treatment of paramoxyvirus viral infections
    Patent number: 9724351
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: August 8, 2017
    Assignee: Alios BioPharma, Inc.
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He
  • COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS
    Publication number: 20150238498
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: August 21, 2013
    Publication date: August 27, 2015
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He
  • ANTIVIRAL COMPOUNDS
    Publication number: 20150065504
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: August 19, 2014
    Publication date: March 5, 2015
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He, Karin Ann Stein