Abstract: A tympanostomy tube placement device has a stem with a needle having a tip configured to pierce a tympanic membrane. A retainer is on the needle and includes four fingers extending axially at a distance from said axis and at 90° circumferential separations in one example. The retainer is movable from a distal position at which it presses radially inwardly against the tube distal flange tabs to retain the distal flange in a folded position, to a proximal position at which the tube distal flange is free to spring out radially to a deployed position. The retainer fingers extend through tube proximal flange passageways and press the tube distal flange inwardly, while leaving a distally-facing face of the proximal flange exposed radially outwardly of the retainer. Hence, the proximal flange has its final deployed configuration throughout, and so can act as a physical stop member against the tympanic membrane and also provides visualisation for the surgeon because it extends radially outwardly of the stem.

Abstract: A tympanostomy tube placement device has a needle with a tip, and a retainer at the needle tip. The retainer is within and retains by pulling radially inwardly a tympanostomy tube distal flange in a folded configuration extending distally. Movement of the needle tip in the proximal direction causes the adhesive bond to break and the distal flange releases to an unconstrained deployed position. Due to the axial folding of the distal flange its radial dimension does not affect deployment through the membrane.

Abstract: A tympanostomy tube placement device has a stem with a needle having a tip configured to pierce a tympanic membrane. A retainer is on the needle and includes four fingers extending axially at a distance from said axis and at 90° circumferential separations in one example. The retainer is movable from a distal position at which it presses radially inwardly against the tube distal flange tabs to retain the distal flange in a folded position, to a proximal position at which the tube distal flange is free to spring out radially to a deployed position. The retainer fingers extend through tube proximal flange passageways and press the tube distal flange inwardly, while leaving a distally-facing face of the proximal flange exposed radially outwardly of the retainer. Hence, the proximal flange has its final deployed configuration throughout, and so can act as a physical stop member against the tympanic membrane and also provides visualisation for the surgeon because it extends radially outwardly of the stem.

Abstract: A tympanostomy tube placement device has a needle with a tip, and a retainer at the needle tip. The retainer is within and retains by pulling radially inwardly a tympanostomy tube distal flange in a folded configuration extending distally. Movement of the needle tip in the proximal direction causes the adhesive bond to break and the distal flange releases to an unconstrained deployed position. Due to the axial folding of the distal flange its radial dimension does not affect deployment through the membrane.

Abstract: A fluidic bridging tube (1), for bridging membranes in the human or animal body allowing the passage of fluid, has a proximal flange (2), an inter lumen connector (3) with a lumen (5) and a distal flange (4). The tube comprises a metal skeleton or scaffold structure (51) and a surrounding polymer which is softer than the scaffold structure. The scaffold structure (51) has a tubular mesh providing structural strength to the inter lumen connector. The tubular mesh has members (61) defining substantial rectangular mesh apertures, and distal crowns (64). At its proximal end the scaffold structure comprises spines (68) extending from a proximal tubular mesh rim (63). The spines provide structural strength to the proximal flange (2). In the preferred embodiment the tube is a tympanostomy tube. A method of manufacturing the tube comprises providing the scaffold structure and over-moulding the outer material to form the shape of the proximal flange, the inter lumen connector with a lumen, and the distal flange.

Abstract: A tympanostomy tube placement device has a stem with a needle having a tip configured to pierce a tympanic membrane. A retainer is on the needle and includes four fingers extending axially at a distance from said axis and at 90° circumferential separations in one example. The retainer is movable from a distal position at which it presses radially inwardly against the tube distal flange tabs to retain the distal flange in a folded position, to a proximal position at which the tube distal flange is free to spring out radially to a deployed position. The retainer fingers extend through tube proximal flange passageways and press the tube distal flange inwardly, while leaving a distally-facing face of the proximal flange exposed radially outwardly of the retainer. Hence, the proximal flange has its final deployed configuration throughout, and so can act as a physical stop member against the tympanic membrane and also provides visualisation for the surgeon because it extends radially outwardly of the stem.

Abstract: The invention relates to an antenna module (3) for a motor vehicle (1) comprising at least one antenna (5, 5a, 5b, 5c) for an infotainment system of the motor vehicle (1), an antenna housing (6) for attaching to an exterior trim part (4) of the motor vehicle (1) and a camera (7) with a camera objective (10) for capturing an environmental region (8) of the motor vehicle (1), wherein the at least one antenna (5, 5a, 5b, 5c) is disposed in an interior of the antenna housing (6), wherein the camera (7) is disposed in the interior of the antenna housing (6) in certain areas, wherein the camera objective (10) is disposed in a passage opening (25) of a housing wall (26) of the antenna housing (6) corresponding to the camera objective (10) at least in certain areas, and the antenna module (3) comprises a sealing element (27) for sealing a gap between the housing wall (26) adjoining to the passage opening (25) and the camera objective (10).

Abstract: The invention relates to a method for manufacturing a camera (4) for a motor vehicle (1), in which an interface device (14) for connecting the camera (4) with a data bus of the motor vehicle (1) is selected from at least two different interface devices (14) and is arranged on a circuit board (13), the circuit board (13) is arranged in an interior space (12) of a front housing (10), a rear housing (15) is manufactured and connected with the front housing (10), wherein the rear housing (15) has a through-opening (16), through which the interface device (15) is passed partly, wherein in manufacture of the rear housing (15) the through-opening (16) is formed in dependency on the selected interface device (14), wherein an outer contour of the rear housing (15) is maintained.

Abstract: The invention relates to a camera (2) for a motor vehicle (1) including a housing (5) configured to shield electromagnetic radiation at least in certain areas, including a circuit board (16) disposed in the housing (5), and including an interface device (11) for connecting the camera (2) to the motor vehicle (1), wherein the interface device (11) is electrically connected to the circuit board (16), wherein the interface device (11) includes a coaxial plug (12) with an inner conductor (13) and an outer conductor (14) and the camera (2) has a connecting device (17) for electrically connecting the outer conductor (14) to the housing (5).

Abstract: A tympanostomy tube placement device has a needle with a tip, and a retainer at the needle tip. The retainer is within and retains by pulling radially inwardly a tympanostomy tube distal flange in a folded configuration extending distally. Movement of the needle tip in the proximal direction causes the adhesive bond to break and the distal flange releases to an unconstrained deployed position. Due to the axial folding of the distal flange its radial dimension does not affect deployment through the membrane.

Abstract: The invention relates to a camera (2) for a motor vehicle (1) including a housing (5) configured to shield electromagnetic radiation at least in certain areas, including a circuit board (16) disposed in the housing (5), and including an interface device (11) for connecting the camera (2) to the motor vehicle (1), wherein the interface device (11) is electrically connected to the circuit board (16), wherein the interface device (11) includes a coaxial plug (12) with an inner conductor (13) and an outer conductor (14) and the camera (2) has a connecting device (17) for electrically connecting the outer conductor (14) to the housing (5).

Abstract: The invention relates to a camera (2) for a motor vehicle (1) including a housing (5) configured to shield electromagnetic radiation at least in certain areas, including a circuit board (16) disposed in the housing (5), and including an interface device (11) for connecting the camera (2) to the motor vehicle (1), wherein the interface device (11) is electrically connected to the circuit board (16), wherein the interface device (11) includes a coaxial plug (12) with an inner conductor (13) and an outer conductor (14) and the camera (2) has a connecting device (17) for electrically connecting the outer conductor (14) to the housing (5).

Abstract: The invention relates to a method for manufacturing a camera (4) for a motor vehicle (1), in which an interface device (14) for connecting the camera (4) with a data bus of the motor vehicle (1) is selected from at least two different interface devices (14) and is arranged on a circuit board (13), the circuit board (13) is arranged in an interior space (12) of a front housing (10), a rear housing (15) is manufactured and connected with the front housing (10), wherein the rear housing (15) has a through-opening (16), through which the interface device (15) is passed partly, wherein in manufacture of the rear housing (15) the through-opening (16) is formed in dependency on the selected interface device (14), wherein an outer contour of the rear housing (15) is maintained.

Abstract: The invention relates to a camera (2) for a motor vehicle (1) including a housing (5) configured to shield electromagnetic radiation at least in certain areas, including a circuit board (16) disposed in the housing (5), and including an interface device (11) for connecting the camera (2) to the motor vehicle (1), wherein the interface device (11) is electrically connected to the circuit board (16), wherein the interface device (11) includes a coaxial plug (12) with an inner conductor (13) and an outer conductor (14) and the camera (2) has a connecting device (17) for electrically connecting the outer conductor (14) to the housing (5).

Abstract: The invention relates to an antenna module (3) for a motor vehicle (1) comprising at least one antenna (5, 5a, 5b, 5c) for an infotainment system of the motor vehicle (1), an antenna housing (6) for attaching to an exterior trim part (4) of the motor vehicle (1) and a camera (7) with a camera objective (10) for capturing an environmental region (8) of the motor vehicle (1), wherein the at least one antenna (5, 5a, 5b, 5c) is disposed in an interior of the antenna housing (6), wherein the camera (7) is disposed in the interior of the antenna housing (6) in certain areas, wherein the camera objective (10) is disposed in a passage opening (25) of a housing wall (26) of the antenna housing (6) corresponding to the camera objective (10) at least in certain areas, and the antenna module (3) comprises a sealing element (27) for sealing a gap between the housing wall (26) adjoining to the passage opening (25) and the camera objective (10).

Abstract: This invention includes compositions and methods for combination chemotherapy, particularly involving at least one chemotherapeutic agent used in combination with chlorotoxin or a derivative thereof.

Abstract: Disclosed is a method of treating cell proliferative disorders, such as cancer, with amounts of chlorotoxin and/or derivatives, analogs or fragments thereof, which are effective to bind to phosphoinositol phospholipids.

Abstract: This invention includes compositions and methods for combination chemotherapy, particularly involving at least one chemotherapeutic agent used in combination with chlorotoxin or a derivative thereof.