Patents by Inventor Carole Burel

Carole Burel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-glycosylation in transformed
    Patent number: 9587245
    Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: March 7, 2017
    Assignees: UNIVERSITE DE ROUEN, L'INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), ALGENICS
    Inventors: Muriel Bardor, Romain Louvet, Bruno Saint-Jean, Carole Burel, Bérangère Baiet, Jean-Paul Cadoret, Patrice Lerouge, Rémy Michel, Aude Carlier
  • N-GLYCOSYLATION IN TRANSFORMED PHAEODACTYLUM TRICORNUTUM
    Publication number: 20140154707
    Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.
    Type: Application
    Filed: July 27, 2011
    Publication date: June 5, 2014
    Applicants: UNIVERSITE DE ROUEN, L'INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), ALGENICS
    Inventors: Muriel Bardor, Romain Louvet, Bruno Saint-Jean, Carole Burel, Berangere Baiet, Jean-Paul Cadoret, Patrice Lerouge, Remy Michel, Aude Carlier
  • Production of glycosylated polypeptides in micro algae
    Patent number: 8728761
    Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: May 20, 2014
    Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Centre National de la Recherche Scientifique—CNRS, Universite de Rouen
    Inventors: Jean-Paul Cadoret, Aude Carlier, Patrice Lerouge, Muriel Bardor, Carole Burel, Florian Maury
  • PRODUCTION OF GLYCOSYLATED POLYPEPTIDES IN MICRO ALGAE
    Publication number: 20110045533
    Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.
    Type: Application
    Filed: February 12, 2009
    Publication date: February 24, 2011
    Applicant: UNIVERSITE DE ROUEN
    Inventors: Jean-Paul Cadoret, Aude Carlier, Patrice Lerouge, Muriel Bardor, Carole Burel, Florian Maury
  • MODIFYING GLYCOPROTEIN PRODUCTION IN PLANS
    Publication number: 20110008837
    Abstract: A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNT1-GalT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNT1) fused to a catalytic domain of beta-1,4galactosyltransferase (GalT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.
    Type: Application
    Filed: June 13, 2008
    Publication date: January 13, 2011
    Inventors: Marc-Andre D-Aoust, Louis-Philippe Vezina, Stephanie Aquin, Estelle Marquet-Blouin, Muriel Bardor, Veronique Gomord, Christophe Rihouey, Thomas Paccalet, Carole Burel, Loic Faye, Patrice Lerouge, Christophe Sourrouille