Patents by Inventor Caroline Baudouin
Caroline Baudouin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11892447Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: GrantFiled: December 16, 2016Date of Patent: February 6, 2024Assignee: Laboratoires ExpanscienceInventors: Stephanie Bredif, Caroline Baudouin
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Patent number: 11604184Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: GrantFiled: June 23, 2017Date of Patent: March 14, 2023Assignee: Laboratoires ExpanscienceInventors: Caroline Baudouin, Stephanie Bredif
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Patent number: 11026441Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths.Type: GrantFiled: August 30, 2018Date of Patent: June 8, 2021Assignee: LABORATOIRES EXPANSCIENCEInventors: Alex Saunois, Caroline Baudouin, Sophie Leclere-Bienfait, Sebastien Garnier, Philippe Msika
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Patent number: 10837958Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: GrantFiled: March 31, 2015Date of Patent: November 17, 2020Assignee: LABORATOIRES EXPANSCIENCEInventors: Caroline Baudouin, Philippe Msika
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Publication number: 20200256853Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.Type: ApplicationFiled: June 21, 2018Publication date: August 13, 2020Applicant: LABORATOIRES EXPANSCIENCEInventors: Gaelle BELLEMERE, Stephanie BREDIF, Gaetan BOYER, Caroline BAUDOUIN
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Publication number: 20200085897Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.Type: ApplicationFiled: September 24, 2019Publication date: March 19, 2020Applicant: LABORATOIRES EXPANSCIENCEInventors: Alex SAUNOIS, Caroline BAUDOUIN, Sophie LECLERE-BIENFAIT, Sebastien GARNIER, Philippe MSIKA
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Patent number: 10463593Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.Type: GrantFiled: July 3, 2015Date of Patent: November 5, 2019Assignee: LABORATOIRES EXPANSCIENCEInventors: Caroline Baudouin, Sophie Leclere-Bienfait, Philippe Msika, Stéphanie Bredif
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Patent number: 10444226Abstract: A method for determining whether the skin surface of a subject is mature/immature in its organization/function, by taking a skin sample and determining the corneodesmosome distribution within the stratum corneum of the sample by an immunoelectron microscopy method.Type: GrantFiled: September 3, 2014Date of Patent: October 15, 2019Assignee: LABORATOIRE EXPANSCIENCEInventors: Philippe Msika, Nadège Lachmann, Caroline Baudouin
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Publication number: 20190242880Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: ApplicationFiled: December 16, 2016Publication date: August 8, 2019Applicant: Laboratoires ExpanscienceInventors: Stephanie BREDIF, Caroline BAUDOUIN
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Publication number: 20190234939Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: ApplicationFiled: June 23, 2017Publication date: August 1, 2019Applicant: Laboratoires ExpanscienceInventors: Caroline BAUDOUIN, Stephanie BREDIF
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Patent number: 10196607Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNF?, filaggrin, TGF?1 and ?1 integrin.Type: GrantFiled: January 12, 2015Date of Patent: February 5, 2019Assignee: LABORATOIRES EXPANSCIENCEInventors: Stephanie Bredif, Caroline Baudouin, Philippe Msika, Marisa Meloni
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Patent number: 10175230Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.Type: GrantFiled: April 22, 2014Date of Patent: January 8, 2019Assignee: LABORATOIRES EXPANSCIENCEInventors: Philippe Msika, Caroline Baudouin, Stephanie Bredif
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Publication number: 20180369193Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths.Type: ApplicationFiled: August 30, 2018Publication date: December 27, 2018Applicant: Laboratoires ExpanscienceInventors: Alex SAUNOIS, Caroline BAUDOUIN, Sophie LECLERE-BIENFAIT, Sebastien GARNIER, Philippe MSIKA
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Patent number: 10143648Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.Type: GrantFiled: November 26, 2015Date of Patent: December 4, 2018Assignee: LABORATOIRES EXPANSCIENCEInventors: Philippe Msika, Caroline Baudouin, Stéphanie Bredif
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Patent number: 10092495Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.Type: GrantFiled: February 11, 2014Date of Patent: October 9, 2018Assignee: LABORATOIRE EXPANSCIENCEInventors: Philippe Msika, Caroline Baudouin
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Publication number: 20180149640Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: ApplicationFiled: March 31, 2015Publication date: May 31, 2018Applicant: Laboratoire ExpanscienceInventors: Caroline BAUDOUIN, Philippe MSIKA
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Patent number: 9952201Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.Type: GrantFiled: September 24, 2014Date of Patent: April 24, 2018Assignee: LABORATORIES EXPANSCIENCEInventors: Caroline Baudouin, Stephanie Bredif, Philippe Msika
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Publication number: 20170326061Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or—improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.Type: ApplicationFiled: November 26, 2015Publication date: November 16, 2017Applicant: LABORATOIRES EXPANSCIENCEInventors: Philippe MSIKA, Caroline BAUDOUIN, Stéphanie BREDIF
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Publication number: 20170241989Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: ApplicationFiled: March 31, 2015Publication date: August 24, 2017Applicant: LABORATOIRES EXPANSCIENCEInventor: Caroline Baudouin
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Publication number: 20170157019Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.Type: ApplicationFiled: July 3, 2015Publication date: June 8, 2017Applicant: LABORATOIRES EXPANSCIENCEInventors: Caroline BAUDOUIN, Sophie LECLERE- BIENFAIT, Philippe MSIKA, Stéphanie BREDIF