Patents by Inventor Caroline Dean
Caroline Dean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8735173Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.Type: GrantFiled: March 28, 2012Date of Patent: May 27, 2014Assignee: Women's and Children's HospitalInventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
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Publication number: 20120184050Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity. Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.Type: ApplicationFiled: March 28, 2012Publication date: July 19, 2012Applicant: WOMEN'S AND CHILDREN'S HOSPITALInventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
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Patent number: 8173443Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.Type: GrantFiled: March 31, 2004Date of Patent: May 8, 2012Assignee: Women's and Children's HospitalInventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
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Patent number: 7615224Abstract: Multiplexing bead technology is used for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Diagnostic compositions include microspheres conjugated to purified antibodies that specifically bind LSD target antigens: saposin, LAMP-1, ?-iduronidase, ?-glucosidase, ?-glucosidase, 2-sulphatase, 4-sulphatase, ?-galactosidase, sphingomyelinase, 3-sulphatase or sulphamidase. The target antigens are naturally present in biological fluids or tissues of either LSD or non-LSD patients.Type: GrantFiled: December 1, 2005Date of Patent: November 10, 2009Assignee: Women's and Children's HospitalInventors: Peter John Meikle, John Joseph Hopwood, Douglas Alexander Brooks, Caroline Dean
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Publication number: 20070265432Abstract: Multiplexing bead technology is used for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Diagnostic compositions include microspheres conjugated to purified antibodies that specifically bind LSD target antigens: saposin, LAMP-1, ?-iduronidase, ?-glucosidase, ?-glucosidase, 2-sulphatase, 4-sulphatase, ?-galactosidase, sphingomyelinase, 3-sulphatase or sulphamidase. The target antigens are naturally present in biological fluids or tissues of either LSD or non-LSD patients.Type: ApplicationFiled: December 1, 2005Publication date: November 15, 2007Applicant: Women's and Children's HospitalInventors: Peter Meikle, John Hopwood, Douglas Brooks, Caroline Dean
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Patent number: 7253274Abstract: An isolated nucleic acid obtainable from the VRN2 locus of a plant, which nucleic acid encodes a polypeptide which is capable of affecting one or more physical characteristics of a plant into which the nucleic acid is introduced, the physical characteristics being selected from vernalization response, flowering time, leaf size, and/or shape or shade avoidance response; alleles, fragment and derivatives thereof; polypeptides encoded by such nucleic acids; antibodies to such peptides.Type: GrantFiled: September 16, 2004Date of Patent: August 7, 2007Assignee: Pioneer Hi-Bred InternationalInventors: Caroline Dean, Anthony Gendall
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Patent number: 7230158Abstract: Disclosed are isolated nucleic acids obtainable from the FRI locus of plants which encode polypeptides capable of specifically altering, particularly delaying, the flowering time of a plant into which the nucleic acid is introduced. One preferred embodiment is the FRI nucleotide sequence which encodes the polypeptide of FIG. 6 (see the sequence of FIG. 5, particularly bases 362-2188 thereof) or sequences degeneratively equivalent to these. Also provided are variant sequences (e.g. alleles, orthologues, derivatives) and complementary sequences, plus vectors, host cells, plants and associated processes of production and methods of use e.g. for influencing or affecting flowering time in a plant by expression or suppression of FRI or variant sequences.Type: GrantFiled: July 19, 2004Date of Patent: June 12, 2007Assignee: Pioneer High-Bred International, Inc.Inventors: Urban Johanson, Joanne West, Caroline Dean
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Publication number: 20070072243Abstract: A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against other lysosomal proteins, enzymes, or enzyme activities. Compounds, reagents, and methods for identifying and quantifying multiple target enzymes and proteins.Type: ApplicationFiled: March 31, 2004Publication date: March 29, 2007Inventors: Peter Meikle, John Hopwood, Douglas Brooks, Caroline Dean
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Patent number: 7045682Abstract: Provided are isolated nucleic acid molecules which comprise VRN1 nucleotide sequences, which encode a polypeptide which is capable of specifically altering the vernalisation response of a plant into which the nucleic acid is introduced and expressed. Examples include cDNA and gDNA sequences (see e.g., Annex I). Also provided are variant molecules which may be derivatives or homologues (e.g., alleles, or paralogues such as RTV1), plus also complementary molecules. Corresponding polypeptides form a further part of the invention. The invention also provides methods and materials for preparing and using these molecules, e.g., in the production of plants having modified vernalisation characteristics. Also provided are methods for influencing and assessing the vernalisation phenotype of a plant.Type: GrantFiled: September 13, 2000Date of Patent: May 16, 2006Assignee: Pioneer Hi-Bred InternationalInventors: Caroline Dean, Yaron Yakov Levy
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Patent number: 6949694Abstract: The invention discloses nucleic acid encoding an FY polypeptide with the sequence shown in Annex 2. Also provided are vectors, host cells and plants. Methods of the invention include the use of nucleic acids to express or down-regulate FY in plants. The methods may be used to affect flowering time or juvenile phase length in plants.Type: GrantFiled: July 11, 2002Date of Patent: September 27, 2005Assignee: Pioneer Hi-Bred International, Inc.Inventors: Gordon Grant Simpson, Caroline Dean, Paul Dijkwel
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Publication number: 20050132446Abstract: An isolated nucleic acid obtainable from the VRN2 locus of a plant, which nucleic acid encodes a polypeptide which is capable of affecting one or more physical characteristics of a plant into which the nucleic acid is introduced, the physical characteristics being selected from vernalization response, flowering time, leaf size, and/or shape or shade avoidance response; alleles, fragment and derivatives thereof; polypeptides encoded by such nucleic acids; antibodies to such peptides.Type: ApplicationFiled: September 16, 2004Publication date: June 16, 2005Inventors: Caroline Dean, Anthony Gendall
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Publication number: 20050060774Abstract: Disclosed are isolated nucleic acids obtainable from the FRI locus of plants which encode polypeptides capable of specifically altering, particularly delaying, the flowering time of a plant into which the nucleic acid is introduced. One preferred embodiment is the FRI nucleotide sequence which encodes the polypeptide of FIG. 6 (see the sequence of FIG. 5, particularly bases 362-2188 thereof) or sequences degeneratively equivalent to these. Also provided are variant sequences (e.g. alleles, orthologues, derivatives) and complementary sequences, plus vectors, host cells, plants and associated processes of production and methods of use e.g. for influencing or affecting flowering time in a plant by expression or suppression of FRI or variant sequences.Type: ApplicationFiled: July 19, 2004Publication date: March 17, 2005Inventors: Urban Johanson, Joanne West, Caroline Dean
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Publication number: 20030084483Abstract: The invention discloses nucleic acid encoding an FY polypeptide with the sequence shown in Annex 2. Also provided are vectors, host cells and plants. Methods of the invention include the use of nucleic acids to express or down-regulate FY in plants. The methods may be used to affect flowering time or juvenile phase length in plants.Type: ApplicationFiled: July 11, 2002Publication date: May 1, 2003Inventors: Gordon Grant Simpson, Caroline Dean, Paul Pieter Dijkwel
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Patent number: 6140085Abstract: FCA genes of Arabidopsis thaliana and Brassica napus are provided, enabling flowering characteristics, particularly timing of flowering, to be influenced in transgenic plants. Timing of flowering may be delayed or hastened using sense and antisense expression, also various mutants and alleles, including alternatively spliced forms.Type: GrantFiled: December 1, 1997Date of Patent: October 31, 2000Assignee: Plant BioScience LimitedInventors: Caroline Dean, Richard Colin Macknight, Ian Bancroft, Clare Katharine Lister
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Patent number: 5349127Abstract: DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.Type: GrantFiled: October 26, 1992Date of Patent: September 20, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventors: Caroline Dean, Patricia A. Harder, Kenneth J. Leto, Daniel P. O'Keefe, Charles A. Omer, James A. Romesser, James M. Tepperman
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Patent number: 5212296Abstract: DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.Type: GrantFiled: August 23, 1990Date of Patent: May 18, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventors: Caroline Dean, Patricia A. Harder, Kenneth J. Leto, Daniel P. O'Keefe, Charles A. Omer, James A. Romesser, James M. Tepperman
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Patent number: 4962028Abstract: Promoter sequences from the gene from the small subunit of ribulose-1,5-bisphosphate carboxylase are disclosed. Expression cassettes containing a promoter sequence, a linker region, and a 3' fragment are also disclosed. The promotor sequences and expression cassettes are useful for expressing foreign genes to high levels in transformed plants.Type: GrantFiled: July 9, 1986Date of Patent: October 9, 1990Assignee: DNA Plant Technology CorporationInventors: John R. Bedbrook, Caroline Dean, Pamela Dunsmuir