Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Tube management structures for an automatic compounder system are provided. A tube management structure may be implemented as a backpack attached to a pump cartridge of the compounder system. Flexible tubing may extend from an output port of the pump cartridge into an internal recess of the backpack. A connector may be provided on an end of the tubing that extends out of the backpack through an opening in the backpack. An additional opening may be provided in the backpack in which the connector may be stored when the cartridge is not in use by the system. The compounder system may include a sensor configured to view the connector through an opening in the cartridge when the connector is disposed in the additional opening. The tubing may be pulled from within the backpack so that the connector can be connected to a receiving container.

Abstract: Tube management structures for an automatic compounder system are provided. A tube management structure may be implemented as a backpack attached to a pump cartridge of the compounder system. Flexible tubing may extend from an output port of the pump cartridge into an internal recess of the backpack. A connector may be provided on an end of the tubing that extends out of the backpack through an opening in the backpack. An additional opening may be provided in the backpack in which the connector may be stored when the cartridge is not in use by the system. The compounder system may include a sensor configured to view the connector through an opening in the cartridge when the connector is disposed in the additional opening. The tubing may be pulled from within the backpack so that the connector can be connected to a receiving container.