Patents by Inventor Carrie Enever

Carrie Enever has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BINDING MOLECULES
    Publication number: 20220220215
    Abstract: The disclosure relates to multispecific agents that simultaneously bind CD137 and PD-1 and which comprise a single domain antibody specific to CD137 and a moiety that binds PD-1, for example a single domain antibody. The disclosure also relates to therapeutic and diagnostic applications of such agents, for example in the treatment of a cancer.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 14, 2022
    Inventors: Carrie ENEVER, Colette JOHNSTON, James LEGG, Pavel PISA, Martyna LEWANDOWSKA, Iain SCOTT
  • COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE
    Publication number: 20130230540
    Abstract: The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain.
    Type: Application
    Filed: July 10, 2012
    Publication date: September 5, 2013
    Applicant: Domantis Limited
    Inventors: Steven Holmes, Carrie Enever, Steven Grant, David Sansom
  • DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES
    Publication number: 20130171146
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: August 21, 2012
    Publication date: July 4, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • Dual-specific IL-1?/IL-1? antibodies
    Patent number: 8324350
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: December 4, 2012
    Assignee: Abbott Laboratories
    Inventors: Chung-ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna
  • Compositions monovalent for CD28 binding and methods of use
    Publication number: 20110097339
    Abstract: The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain.
    Type: Application
    Filed: June 18, 2009
    Publication date: April 28, 2011
    Applicant: Domantis Limited
    Inventors: Steven Holmes, Carrie Enever, Steven Grant, David Sansom
  • Dual-specific IL-1A/IL-1b antibodies
    Publication number: 20090291081
    Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.
    Type: Application
    Filed: December 28, 2007
    Publication date: November 26, 2009
    Inventors: Chung-Ming Hsieh, Bradford L. McRae, Yuliya Kutskova, John E. Memmott, Michael Roguska, Ian Tomlinson, Carrie Enever, Steven Grant, Mihriban Tuna