Patents by Inventor Carson R. Loomis

Carson R. Loomis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying reduced internalization transmembrane receptor agonists
    Patent number: 7297503
    Abstract: Described herein are methods of identifying a transmembrane receptor (TMR) agonist and compounds identified by this method. The TMR agonist (TMRA) is capable of activating TMR signaling while exhibiting reduced TMR internalization over a control compound.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: November 20, 2007
    Assignee: Molecular Devices Corporation
    Inventors: Carson R Loomis, Robert H. Oakley, Shuntai Wang, Allen E. Eckhardt
  • Microelectronic device for electrochemical detection of nucleic acid hybridization
    Patent number: 7049068
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: May 23, 2006
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Electrochemical detection of nucleic acid hybridization
    Publication number: 20020106683
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Application
    Filed: November 6, 2001
    Publication date: August 8, 2002
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Electrochemical detection of nucleic acid hybridization
    Patent number: 6361951
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: March 26, 2002
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Microelectronic device
    Patent number: 6132971
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: October 17, 2000
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
    Patent number: 5968745
    Abstract: A polymer-electrode including (a) a substrate having a conductive working surface; and (b) a polymer layer on the conductive working surface. The polymer layer has a plurality of microfluidic reaction openings distributed throughout the layer. An oligonucleotide probe can be attached to the polymer layer and is available to capture target nucleic acid. A soluble mediator can diffuse freely and transfer electrons from the preselected base in the hybridized nucleic acid to the conductive working surface of the substrate. An electronic signal generated from the electron transfer reaction is detected and quantitated.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: October 19, 1999
    Assignees: The University of North Carolina at Chapel Hill, Xanthon, Inc.
    Inventors: H. Holden Thorp, Carson R. Loomis, Mary E. Napier
  • Electrochemical detection of nucleic acid hybridization
    Patent number: 5871918
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: February 16, 1999
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim