Abstract: The present invention relates to the finding that vault RNAs (vtRNA) associate with p62, an important factor of cellular autophagy. The invention provides the modulation of the binding of vtRNA to p62 as a novel strategy to influence autophagic flux in cells. Thus, the present invention provides inhibitors of vtRNA for use in the treatment of diseases associated with a pathological reduced or insufficient autophagy in cells, such as cancer and neurodegenerative disorders. Further provided are methods for screening novel therapeutic compounds modulating autophagy via the p62/vtRNA axis.

Abstract: A vertical roll mill may include a grinding plate, a grinding roll, a nozzle ring that horizontally surrounds the grinding plate, an air feed apparatus disposed under the nozzle ring, a discharge element disposed below or in a region of the air feed apparatus, and a bypass apparatus disposed in the nozzle ring. The bypass apparatus may form a connection between the nozzle ring and the discharge element. Further, the bypass apparatus can discharge particles that are difficult to grind, for example, ductile particles such as iron particles, from the grinding process. In some examples, the bypass apparatus includes a gas-impermeable outer skin in the region of the air feed apparatus.

Abstract: The present invention relates to the finding that vault RNAs (vtRNA) associate with p62, an important factor of cellular autophagy. The invention provides the modulation of the binding of vtRNA to p62 as a novel strategy to influence autophagic flux in cells. Thus, the present invention provides inhibitors of vtRNA for use in the treatment of diseases associated with a pathological reduced or insufficient autophagy in cells, such as cancer and neurodegenerative disorders. Further provided are methods for screening novel therapeutic compounds modulating autophagy via the p62/vtRNA axis.

Abstract: A vertical roll mill may include a grinding plate, a grinding roll, a nozzle ring that horizontally surrounds the grinding plate, an air feed apparatus disposed under the nozzle ring, a discharge element disposed below or in a region of the air feed apparatus, and a bypass apparatus disposed in the nozzle ring. The bypass apparatus may form a connection between the nozzle ring and the discharge element. Further, the bypass apparatus can discharge particles that are difficult to grind, for example, ductile particles such as iron particles, from the grinding process. In some examples, the bypass apparatus includes a gas-impermeable outer skin in the region of the air feed apparatus.

Abstract: The invention relates to a roller mill having a grinding table, at least one grinding roller and at least two drives with a rotor winding for driving the roller mill and at least one adjustment device for adjusting the motor torque of at least one drive, the adjustment device being connected to the rotor winding of at least one drive in order to influence the rotor current.

Abstract: The invention relates to a roller mill having a grinding table, at least one grinding roller and at least two drives with a rotor winding for driving the roller mill and at least one adjustment device for adjusting the motor torque of at least one drive, the adjustment device being connected to the rotor winding of at least one drive in order to influence the rotor current.