Patents by Inventor Casey C. Kopczynski

Casey C. Kopczynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric oligomeric compounds for modulation of splicing
    Patent number: 9157081
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: October 13, 2015
    Assignees: Isis Pharmaceuticals, Inc., Sarepta Therapeutics
    Inventors: C. Frank Bennett, Nicholas M. Dean, Ryszard M. Kole, Casey C. Kopczynski
  • CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING
    Publication number: 20140005374
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 2, 2014
    Inventors: C. Frank Bennett, Nicholas M. Dean, Ryszard M. Kole, Casey C. Kopczynski
  • Chimeric oligomeric compounds for modulation of splicing
    Patent number: 8501703
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: August 6, 2013
    Assignees: Isis Pharmaceuticals, Inc., Sarepta Therapeutics
    Inventors: C. Frank Bennett, Nicholas M. Dean, Ryszard Kole, Casey C. Kopczynski
  • CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING
    Publication number: 20110039334
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
    Type: Application
    Filed: August 29, 2006
    Publication date: February 17, 2011
    Inventors: C. Frank Bennett, Nicholas M. Dean, Ryszard M. Kole, Casey C. Kopczynski