Patents by Inventor Casim A. Sarkar

Casim A. Sarkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PRODUCING PLACENTAL CELLS
    Publication number: 20230183643
    Abstract: Certain embodiments provide a method of producing a population of induced multipotent placental cells, the method comprising culturing a population of pluripotent stem cells in the presence of an induction media comprising a retinoid, and optionally a Wnt signaling agonist. Certain embodiments also provide cells, compositions, kits and methods of use thereof.
    Type: Application
    Filed: September 19, 2022
    Publication date: June 15, 2023
    Applicant: Regents of the University of Minnesota
    Inventors: Samira Azarin, Casim A. Sarkar, Kristen A. Lemke
  • BACTERIAL BIOSENSOR SYSTEM
    Publication number: 20230063616
    Abstract: The disclosure relates to a biosensor on the bacterial cell surface for sensing and responding to extracellular molecules. Related methods of using the bacterial cells to inducibly express a protein of interest and/or a bioactive RNA molecule in a subject are disclosed. Related methods of using the bacterial cells to inducibly express a protein of interest or to detect a target of interest in a sample are also disclosed.
    Type: Application
    Filed: August 10, 2022
    Publication date: March 2, 2023
    Inventors: Casim A. Sarkar, Samira M. Azarin, Qiuge Zhang
  • Methods of using G-CSF analog compositions
    Patent number: 7402304
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: July 22, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • Methods of using G-CSF analog compositions
    Patent number: 7371370
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: May 13, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger
  • G-CSF analog compositions and methods
    Patent number: 6946548
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 20, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • G-CSF analog compositions and methods
    Publication number: 20050123508
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 9, 2005
    Inventors: Casim Sarkar, Douglas Lauffenburger, Bruce Tidor
  • G-CSF analog compositions and methods
    Publication number: 20050003453
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Application
    Filed: August 3, 2004
    Publication date: January 6, 2005
    Inventors: Casim Sarkar, Douglas Lauffenburger
  • Method for screening analogs of G-CSF
    Patent number: 6790628
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 14, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger
  • G-CSF analog compositions and methods
    Publication number: 20030166527
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Application
    Filed: September 10, 2001
    Publication date: September 4, 2003
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • G-CSF analog compositions and methods
    Publication number: 20020151488
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Application
    Filed: September 10, 2001
    Publication date: October 17, 2002
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger