Abstract: A tamper-evident package for pharmaceuticals is described. The package includes a case. A tray holding pharmaceuticals slides in and out of the case. The package includes an alarm that can be set to armed and triggered mode. When the alarm is armed, the system of the package changes the alarm to triggered in response to the tray being opened. The package may engage an access indicator in response to the alarm being triggered. The package may also flash an indicator light upon request, prior to opening the tray, to indicate whether the alarm was triggered since being previously armed. The alarm can be armed again if it is triggered, by entering a security code while the tray is closed.

Abstract: A tamper-evident package for pharmaceuticals is described. The package includes a case. A tray holding pharmaceuticals slides in and out of the case. The package includes an alarm that can be set to armed and triggered mode. When the alarm is armed, the system of the package changes the alarm to triggered in response to the tray being opened. The package may engage an access indicator in response to the alarm being triggered. The package may also flash an indicator light upon request, prior to opening the tray, to indicate whether the alarm was triggered since being previously armed. The alarm can be armed again if it is triggered, by entering a security code while the tray is closed.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.