Patents by Inventor Catherine Asleson Dundon
Catherine Asleson Dundon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230312253Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: ApplicationFiled: May 19, 2023Publication date: October 5, 2023Applicant: CARGILL, INCORPORATEDInventors: Catherine Asleson DUNDON, Pirkko SUOMINEN, Aristos ARISTIDOU, Brian J. RUSH, Kari KOIVURANTA, Benjamin Matthew HAUSE, Thomas William McMULLIN, Kevin ROBERG-PEREZ
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Patent number: 11691817Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: GrantFiled: January 21, 2021Date of Patent: July 4, 2023Assignee: CARGILL, INCORPORATEDInventors: Catherine Asleson Dundon, Pirkko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Publication number: 20230049887Abstract: The invention relates to methods and compositions for the recombinant production of animal protein for use in animal food, particularly pet food.Type: ApplicationFiled: January 29, 2020Publication date: February 16, 2023Inventors: Karin Pernilla Turner Audibert, Richard W. Kelleman, II, Anthony George Day, Julie Marie Struble, Ryan Michael Yamka, Catherine Asleson Dundon, Luis N. Brandao
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Publication number: 20210155411Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: ApplicationFiled: January 21, 2021Publication date: May 27, 2021Applicant: Cargill, IncorporatedInventors: Catherine Asleson DUNDON, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Patent number: 10899544Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: GrantFiled: March 30, 2018Date of Patent: January 26, 2021Assignee: CARGILL, INCORPORATEDInventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Publication number: 20200377302Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: ApplicationFiled: March 30, 2018Publication date: December 3, 2020Applicant: Cargill IncorporatedInventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Publication number: 20200236971Abstract: The invention relates to methods and compositions for the recombinant production of animal protein for use in animal food, particularly pet food.Type: ApplicationFiled: January 29, 2020Publication date: July 30, 2020Inventors: Karin Pernilla Turner Audibert, Richard W. Kelleman, III, Anthony George Day, Julie Marie Struble, Ryan Michael Yamka, Catherine Asleson Dundon
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Publication number: 20180257864Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: ApplicationFiled: March 30, 2018Publication date: September 13, 2018Applicant: Cargill IncorporatedInventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Publication number: 20180179557Abstract: The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: ApplicationFiled: February 12, 2018Publication date: June 28, 2018Inventors: Reid FELDMAN, Uvini GUNAWARDENA, Jun URANO, Peter MEINHOLD, Aristos ARISTIDOU, Catherine Asleson DUNDON, Christopher SMITH
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Patent number: 9926577Abstract: The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: GrantFiled: September 10, 2014Date of Patent: March 27, 2018Assignee: Gevo, Inc.Inventors: Reid M. Renny Feldman, Uvini Gunawardena, Jun Urano, Peter Meinhold, Aristos Aristidou, Catherine Asleson Dundon, Christopher Smith
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Patent number: 9657315Abstract: The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: GrantFiled: December 21, 2015Date of Patent: May 23, 2017Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&DInventors: Catherine Asleson Dundon, Christopher Smith, Piruz Nahreini, Johan Thevelein, Sofie Saerens
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Patent number: 9506074Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: GrantFiled: September 19, 2013Date of Patent: November 29, 2016Assignee: GEVO, INC.Inventors: Thomas Buelter, Andrew Hawkins, Stephanie Porter-Scheinman, Peter Meinhold, Catherine Asleson Dundon, Aristos Aristidou, Jun Urano, Doug Lies, Matthew Peters, Melissa Dey, Justas Jancauskas, Julie Kelly, Ruth Berry
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Publication number: 20160108441Abstract: The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: ApplicationFiled: December 21, 2015Publication date: April 21, 2016Inventors: Catherine Asleson Dundon, Christopher Smith, Piruz Nahreini, Johan Thevelein, Sofie Saerens
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Patent number: 9249420Abstract: The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: GrantFiled: May 31, 2011Date of Patent: February 2, 2016Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&DInventors: Catherine Asleson Dundon, Christopher Smith, Piruz Nahreini, Johan Thevelein, Sofie Saerens
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Publication number: 20150315616Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.Type: ApplicationFiled: May 25, 2015Publication date: November 5, 2015Inventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
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Publication number: 20150259710Abstract: The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise at least one nucleic acid molecule encoding a polypeptide with keto-isovalerate decarboxylase (KIVD) activity, wherein said polypeptide is at least about 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a polypeptide selected from SEQ ID NOs: 1-214. Also provided are modified decarboxylases exhibiting an improved ability to utilize ?-ketoisovalerate as a substrate in various beneficial enzymatic conversions.Type: ApplicationFiled: July 30, 2012Publication date: September 17, 2015Applicant: Gevo, Inc.Inventors: Catherine Asleson Dundon, Kevin Roberg-Perez, Christopher Snow, Peter Meinhold
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Publication number: 20150218596Abstract: The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: ApplicationFiled: September 10, 2014Publication date: August 6, 2015Inventors: Reid M. Renny Feldman, Uvini Gunawardena, Jun Urano, Peter Meinhold, Aristos Aristidou, Catherine Asleson Dundon, Christopher Smith
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Publication number: 20150152443Abstract: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme.Type: ApplicationFiled: July 1, 2014Publication date: June 4, 2015Inventors: Catherine Asleson Dundon, Aristos Aristidou, Andrew Hawkins, Doug Lies, Lynne H. Albert
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Publication number: 20140308721Abstract: The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: ApplicationFiled: January 17, 2014Publication date: October 16, 2014Applicant: Gevo, Inc.Inventors: Jun Urano, Catherine Asleson Dundon, Peter Meinhold, Reid M. Renny Feldman, Aristos A. Aristidou, Andrew Hawkins, Thomas Buelter, Matthew Peters, Doug Lies, Stephanie Porter-Scheinman, Christopher Smith, Ruth Berry, Ishmeet Kalra
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Publication number: 20140212953Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: ApplicationFiled: September 19, 2013Publication date: July 31, 2014Applicant: GEVO, Inc.Inventors: Thomas BUELTER, Andrew Hawkins, Stephanie Porter-Scheinman, Peter Meinhold, Catherine Asleson Dundon, Aristos Aristidou, Jun Urano, Doug Lies, Matthew Peters, Melissa Dey, Justas Jancauskas, Kent Evans, Julie Kelly, Ruth Berry